Material Safety Data Sheet **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: 1-Butanol, 99% Catalog Numbers: AC107690000, AC107690010, AC107690025, AC107690200 Synonyms: Butanol; n-Butanol; n-Butanol; Butan-1-ol; 1-Butan-1-ol; n-Butyl alcohol; 1-Butyl alcohol; n-Butyl alcohol; Butyl hydroxide; 1-Hydroxybutane; Methylolpropane; Propylcarbinol; Propylmethanol Company Identification (Europe): Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium Company Identification (USA): Acros Organics One Reagent Lane Fairlawn, NJ 07410 For information in North America, call: 800-ACROS-01 For information in Europe, call: 0032(0) 14575211 For emergencies in the US, call CHEMTREC: 800-424-9300 For emergencies in Europe, call: 0032(0) 14575299 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 71-36-3 |n-Butyl alcohol | 99 | 200-751-6 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: XN Risk Phrases: 10 20 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Flammable. Harmful by inhalation. Potential Health Effects Eye: Causes severe eye irritation. May cause corneal edema and inflammation. May cause lacrimation (tearing), blurred vision, and photophobia. Skin: Causes severe skin irritation. May be harmful if absorbed through the skin. Repeated or prolonged exposure may cause drying and cracking of the skin. Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May be harmful if swallowed. Aspiration may be fatal. May be absorbed from the gastrointestinal tract. Inhalation: Causes respiratory tract irritation. May cause cardiovascular disturbances, hearing abnormalities, central nervous system depression, muscle weakness, and possible death due to respiratory failure. May be absorbed through the lungs. Chronic: Prolonged or repeated skin contact may cause defatting and dermatitis. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. Prolonged exposure may cause liver, kidney, and heart damage. May cause damage to the auditory nerve (some hearing loss) and vestibular injury. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Possible aspiration hazard. Get medical aid immediately. Wash mouth out with water. Inhalation: Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: Alcoholic beverage consumption may enhance the toxic effects of this substance. Persons with liver, kidney, or central nervous system diseases may be at increased risk from exposure to this product. Butanol is especially toxic if aspirated. Treat symptomatically and supportively. **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May be ignited by heat, sparks, and flame. Containers may explode when heated. Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. Cool containers with flooding quantities of water until well after fire is out. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as saw dust. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from explosives, organic peroxides, poisons, and radioactive materials. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR :1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Liquid Appearance: colourless Odor: sweetish odor - putrid odor - fusel oil odor pH: Not available. Vapor Pressure: 6.5 mm Hg @ 25 deg C Vapor Density: 2.6 (Air=1) Evaporation Rate: 0.46 (Butyl acetate=1) Viscosity: 2.94 cP at 20 d Boiling Point: 117.4 deg C Freezing/Melting Point: -90 deg C Autoignition Temperature: 343 deg C ( 649.40 deg F) Flash Point: 37 deg C ( 98.60 deg F) Explosion Limits, lower: 1.4 vol % Explosion Limits, upper: 11.2 vol % Decomposition Temperature: Not available. Solubility: Soluble. Specific Gravity/Density: 0.810 (Water=1) Molecular Formula: CH3(CH2)2CH2OH Molecular Weight: 74.12 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, ignition sources, excess heat. Incompatibilities with Other Materials: Oxidizing agents, reducing agents, acid chlorides, alkali metals, aluminum, copper, copper alloys, halogens, organic peroxides, acid anhydrides, chromium trioxide, mineral acids. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 71-36-3: EO1400000 LD50/LC50: CAS# 71-36-3: Draize test, rabbit, eye: 2 mg Severe; Draize test, rabbit, eye: 2 mg/24H Severe; Draize test, rabbit, skin: 405 mg/24H Moderate; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, rat: LC50 = 8000 ppm/4H; Oral, mouse: LD50 = 2680 mg/kg; Oral, rabbit: LD50 = 3484 mg/kg; Oral, rat: LD50 = 790 mg/kg; Skin, rabbit: LD50 = 3400 mg/kg. Carcinogenicity: n-Butyl alcohol - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: Mutation data has been reported. Teratogenicity: Oral, rat: TDLo = 35295 mg/kg (female 1-15 day(s) after conception) Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) and Effects on Newborn - biochemical and metabolic.; Inhalation, rat: TCLo = 8000 ppm/7H (female 1-19 day(s) after conception) Specific Developmental Abnormalities - musculoskeletal system. Reproductive Effects: Oral, rat: TDLo = 35295 mg/kg (female 1-15 day(s) after conception) Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) and pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) and post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants). Neurotoxicity: No information available. Mutagenicity: Sex Chromosome Loss and Nondisjunction: Aspergillus nidulans = 7000 ppm.; Sex Chromosome Loss and Nondisjunction: Hamster, Lung = 100 mmol/L. Other Studies: None. **** SECTION 12 - ECOLOGICAL INFORMATION **** Ecotoxicity: Fish: Fathead Minnow: LC50 = 1510-1730 mg/L; 96 Hr; Static bioassay at 24.7&C (pH 7.64)Water flea Daphnia: EC50 = 1980-1983 mg/L; 48 Hr; UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 2817-3710 mg/L; 5,30 min; Microtox testRelease of n-butanol to soil may result in volatilization from the soil surface and biodegradation is expected to be significant. n-Butanol should not bind strongly to soil and so is expected to leach into groundwater. Release of n-butanol to water is expected to result in biodegradation and in volatilization from the water surface. Photooxidation by hydroxyl radicals is expected to be slow. **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT Shipping Name: BUTANOLS Hazard Class: 3 UN Number: UN1120 Packing Group: III Canadian TDG Shipping Name: BUTANOLS Hazard Class: 3 UN Number: UN1120 **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 71-36-3 is listed on the TSCA inventory. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE n-Butyl alcohol can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 10 Flammable. R 20 Harmful by inhalation. Safety Phrases: S 16 Keep away from sources of ignition - No smoking. WGK (Water Danger/Protection) CAS# 71-36-3: 1 United Kingdom Occupational Exposure Limits CAS# 71-36-3: OES-United Kingdom, STEL 50 ppm STEL; 154 mg/m3 STEL Canada CAS# 71-36-3 is listed on Canada's DSL List. CAS# 71-36-3 is listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 71-36-3: OEL-AUSTRALIA:TWA 50 ppm (150 mg/m3);Skin OEL-AUSTRIA:TWA 100 ppm (300 mg/m3) OEL-BELGIUM:STEL 50 ppm (152 mg/m3);Skin OEL-CZECHOSLOVAKIA:TWA 100 mg/m3;STEL 200 mg/m3 OEL-DENMARK:STEL 50 ppm (150 mg/m3);Skin OEL-FINLAND:TWA 50 ppm (150 mg/m3);STEL 75 ppm (225 mg/m3);Skin OEL-FRANCE:STEL 50 ppm (150 mg/m3) OEL-GERMANY:TWA 100 ppm (300 mg/m3) OEL-HUNGARY:TWA 100 mg/m3;STEL 200 mg/m3;Skin OEL-INDIA:TWA 50 ppm (150 mg/m3);Skin OEL-JAPAN:STEL 50 ppm (150 mg/m3);Skin OEL-THE NETHERLANDS:TWA 50 ppm (150 mg/m3);Skin OEL-THE PHILIPPINES:TWA 100 ppm (300 mg/m3) OEL-RUSSIA:STEL 50 ppm (10 mg/m3) OEL-SWEDEN:TWA 15 ppm (45 mg/m3);STEL 30 ppm (90 mg/m3);Skin OEL-SWITZERLAND:TWA 50 ppm (150 mg/m3);STEL 100 ppm;Skin OEL-TURKEY:TWA 100 ppm (300 mg/m3) OEL-UNITED KINGDOM:TWA 50 ppm (150 mg/m3);STEL 50 ppm;Skin OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 6/10/1999 Revision #3 Date: 3/05/2001 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------