Material Safety Data Sheet **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: 1-Propanol, P.A. Catalog Numbers: AC232070000, AC232070010, AC232070025 Synonyms: Propyl Alcohol; n-Propyl Alcohol; n-Propanol; 1-Hydroxy Propane; Ethyl Carbinol. Company Identification (Europe): Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium Company Identification (USA): Acros Organics One Reagent Lane Fairlawn, NJ 07410 For information in North America, call: 800-ACROS-01 For information in Europe, call: 0032(0) 14575211 For emergencies in the US, call CHEMTREC: 800-424-9300 For emergencies in Europe, call: 0032(0) 14575299 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 71-23-8 |n-Propyl alcohol | 100 | 200-746-9 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: XI F Risk Phrases: 11 41 67 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Highly flammable. Risk of serious damage to eyes. Vapors may cause drowsiness and dizziness.Hygroscopic. Potential Health Effects Eye: May cause moderate eye irritation. May result in corneal injury. Skin: May cause moderate skin irritation. Prolonged and/or repeated contact may cause defatting of the skin and dermatitis. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Inhalation: Inhalation of vapor may cause respiratory tract irritation. May cause effects similar to those described for ingestion. Chronic: Prolonged or repeated skin contact may cause defatting and dermatitis. Chronic exposure may cause liver damage. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Combustion generates toxic fumes. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: Use water spray to cool fire-exposed containers. Use dry chemical, carbon dioxide, or alcohol-resistant foam. Do NOT use straight streams of water. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Use water spray to disperse the gas/vapor. Remove all sources of ignition. Provide ventilation. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Use spark-proof tools and explosion proof equipment. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Do not get on skin or in eyes. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Do not store near combustible materials. Store in a cool, dry place. Store in a tightly closed container. Keep from contact with oxidizing materials. Flammables-area. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: A respiratory protection program that meets OSHA's 29 CFR :1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Liquid Appearance: clear, colorless Odor: alcohol-like pH: Not available. Vapor Pressure: 14.3 mm Hg @ 20 Vapor Density: 2.1 (Air=1) Evaporation Rate: 1.3 (butyl acetate=1) Viscosity: 2.2 mPas 20 deg Boiling Point: 97 deg C @ 760mm Hg Freezing/Melting Point: -127 deg C Autoignition Temperature: 405 deg C ( 761.00 deg F) Flash Point: 15 deg C ( 59.00 deg F) Explosion Limits, lower: 2.2 vol % Explosion Limits, upper: 13.7 vol % Decomposition Temperature: Solubility: Miscible. Specific Gravity/Density: .8040g/cm3 Molecular Formula: C3H8O Molecular Weight: 60.10 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, ignition sources. Incompatibilities with Other Materials: Acid chlorides, acid anhydrides, oxidizing agents, potassium tert-butoxide. Hazardous Decomposition Products: Carbon monoxide, carbon dioxide. Hazardous Polymerization: Will not occur. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 71-23-8: UH8225000 LD50/LC50: CAS# 71-23-8: Draize test, rabbit, eye: 20 mg/24H Moderate; Inhalation, mouse: LC50 = 48 gm/m3; Oral, mouse: LD50 = 6800 mg/kg; Oral, rabbit: LD50 = 2825 mg/kg; Oral, rat: LD50 = 1870 mg/kg; Skin, rabbit: LD50 = 5040 mg/kg. Carcinogenicity: n-Propyl alcohol - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: Oral rat TDLo = 50 gm/kg/81 weeks. 1-Propanol caused liver tumors and leukemia according to RTECs criteria. Teratogenicity: No information available. Reproductive Effects: An exposure of 7000 ppm/7 hours caused a reduction in fertility in male rats and caused fetotoxic effects. A dose of 10000 ppm/7 hours caused musculoskeletal abnormalities and post-implantation mortality. Neurotoxicity: No information available. Mutagenicity: No information available. Other Studies: See actual entry in RTECS for complete information. **** SECTION 12 - ECOLOGICAL INFORMATION **** Other No information available. **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT Shipping Name: N-PROPANOL Hazard Class: 3 UN Number: UN1274 Packing Group: II Canadian TDG Shipping Name: N-PROPANOL Hazard Class: 3 UN Number: UN1274 Other Information: FLASHPOINT 15 C **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 71-23-8 is listed on the TSCA inventory. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE n-Propyl alcohol can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI F Risk Phrases: R 11 Highly flammable. R 41 Risk of serious damage to eyes. R 67 Vapors may cause drowsiness and dizziness. Safety Phrases: S 7 Keep container tightly closed. S 16 Keep away from sources of ignition - No smoking. S 24 Avoid contact with skin. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 39 Wear eye/face protection. WGK (Water Danger/Protection) CAS# 71-23-8: 1 United Kingdom Occupational Exposure Limits CAS# 71-23-8: OES-United Kingdom, TWA 200 ppm TWA; 500 mg/m3 TWA CAS# 71-23-8: OES-United Kingdom, STEL 250 ppm STEL; 625 mg/m3 STEL Canada CAS# 71-23-8 is listed on Canada's DSL List. CAS# 71-23-8 is listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 71-23-8: OEL-AUSTRALIA:TWA 200 ppm (500 mg/m3);STEL 250 ppm;Skin **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 12/10/1997 Revision #5 Date: 3/14/2001 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------