Material Safety Data Sheet Ordering Products What's New Support Who We Are Services SEARCH HOME Français Catalogues Frequently Asked Questions Laboratory Vendor Links Safety Vendor Links Scratch and Dent Sales FisherFast Online - Order Approval Process now available! Laboratory Products Safety Products Services Contact Us Customer Service GJS Mass Measurement 1-877-627-7225 Instrument Service 1-800-267-6633 Mailing Addresses Corporate Profile Employment Global Links President's Message Quality Management Policy Certificates of Analysis Material Safety Data Sheets Site Search Product Search **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: 2-Propanol, 99-100% Catalog Numbers: AC149320200, AC412790040, AC423830040, AC423830200, S77795, S77795-2SPEC, S77795HPLC, S77795SPEC, S77798, A415 20, A415 4, A415-20, A415-4, A41520, A4154, A416 1, A416 20, A416 20 001, A416 200, A416 200 001, A416 200 002, A416 200 003, A416 4, A416 500, A416-1, A416-20, A416-200, A416-4, A416-500 A4161, A41620, A41620 001, A416200, A416200 001, A416200 002, A416200 003, A416200001, A416200002, A416200003, A416200004, A41620001, A41620003, A416200LC, A41620LC, A4164, A4164LOT002, A416500, A416ALC, A416FB115, A416FB19, A416FB200, A416FB50, A416J500, A416P4, A416RB115, A416RB19, A416RB200, A416RB50, A416RS115, A416RS200, A416RS28, A416RS50, A416S 4, A416S-4, A416S4, A416SK 4, A416SK-4, A416SK4, A416SK4LC, A416SS 115, A416SS 50, A416SS-11, A416SS-115, A416SS-20, A416SS-200, A416SS-30, A416SS-50, A416SS115, A416SS28, A416SS50, A417 1, A417 4, A417-1, A417-4, A4171, A4174, A418, A418-20, A418-4, A418-500, A419 1, A419 4, A419-1, A419-4, A4191, A4194, A4194LC, A419RS115, A419RS200, A419RS28, A419SS115, A419SS200, A419SS28, A419SS50, A426F-1GAL, A426P 4, A426P-4, A426P4, A426PJ4, A426S 20, A426S 200, A426S 4, A426S-20, A426S-200, A426S-4, A426S20, A426S200, A426S4, A432-1, A451 1, A451 4, A451-1, A451-4, A4511, A4514, A451CU50, A451J1, A451SK 1, A451SK 4, A451SK-1, A451SK-4, A451SK1, A451SK4, A464 4, A464-4, A4644, A4644LC, A4644LOT002, A464J4, A464RS200, A51120, A5114, A5164LC, A5164LOT001, A519 4, A519-4, A5194, A520 4, A520-4, A5204, A520RS200, A520SS115, A520SS200, A520SS50, BP2621100, BPA416RS-115, BPA416RS-200, BPA416RS-28, BPA416RS-50, CRNA5164, HC 500 1GAL, HC500 1GAL, HC5001GAL, NC9587417, NC9587754, NC9603410, NC9618918, NC9619958, NC9638686 NC9654693, NC9754679, NC9808149, S77952SPEC, XXA416PEROXTES, XXA41920LI, XXA464SK4LI, XXA520ET200LI, XXAC451U200LI, XXPEN0021LI Synonyms: Isopropanol; Dimethylcarbinol; sec-Propyl alcohol; Rubbing alcohol; Petrohol; 1-Methylethanol; 1-Methylethyl alcohol; 2-Hydroxypropane; 2-Propyl alcohol; Isopropyl alcohol; Propan-2-ol. Company Identification: Fisher Scientific 1 Reagent Lane Fairlawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 67-63-0 |2-Propanol | > 99 | 200-661-7 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: XI F Risk Phrases: 11 36 67 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Highly flammable. Irritating to eyes. Vapors may cause drowsiness and dizziness.Hygroscopic. Potential Health Effects Eye: Produces irritation, characterized by a burning sensation, redness, tearing, inflammation, and possible corneal injury. May cause transient corneal injury. Skin: May cause irritation with pain and stinging, especially if the skin is abraded. Isopropanol has a low potential to cause allergic skin reactions; however, rare cases of allergic contact dermatitis have been reported. May be absorbed through intact skin. Ingestion: Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Aspiration of material into the lungs may cause chemical pneumonitis, which may be fatal. Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. May cause narcotic effects in high concentration. Causes upper respiratory tract irritation. Inhalation of vapors may cause drowsiness and dizziness. Chronic: Prolonged or repeated skin contact may cause defatting and dermatitis. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. **** SECTION 4 - FIRST AID MEASURES **** Eyes: In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical aid. Skin: In case of contact, flush skin with plenty of water. Remove contaminated clothing and shoes. Get medical aid if irritation develops and persists. Wash clothing before reuse. Ingestion: Potential for aspiration if swallowed. Get medical aid immediately. Do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Inhalation: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Urine acetone test may be helpful in diagnosis. Hemodialysis should be considered in severe intoxication. Treat symptomatically and supportively. **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. May form explosive peroxides. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: Water may be ineffective. Do NOT use straight streams of water. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. For small fires, use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam. Cool containers with flooding quantities of water until well after fire is out. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Loosen closure cautiously before opening. Contents may develop pressure upon prolonged storage. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Take precautionary measures against static discharges. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Use only with adequate ventilation. Avoid breathing vapor or mist. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. After opening, purge container with nitrogen before reclosing. Periodically test for peroxide formation on long-term storage. Addition of water or appropriate reducing materials will lessen peroxide formation. Store protected from moisture. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use only under a chemical fume hood. Personal Protective Equipment Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR :1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Liquid Appearance: colorless liquid Odor: alcohol-like pH: Not available. Vapor Pressure: 33 mm Hg @ 20 deg C Vapor Density: 2.1 (Air=1) Evaporation Rate: 2.3 (n-butyl acetate=1) Viscosity: 2.27 mPas @ 20C Boiling Point: 82 deg C @ 760 mmHg Freezing/Melting Point: -88 deg C Autoignition Temperature: 399 deg C ( 750.20 deg F) Flash Point: 12 deg C ( 53.60 deg F) Explosion Limits, lower: 2.0 vol % Explosion Limits, upper: 12.7 @ 200&F Decomposition Temperature: Not available. Solubility: Miscible. Specific Gravity/Density: 0.7850 (water=1) Molecular Formula: C3H8O Molecular Weight: 60.09 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Distillation may lead to the formation of peroxides. This material may be sensitive to peroxide formation. Conditions to Avoid: Incompatible materials, light, ignition sources, acids, excess heat, exposure to moist air or water, oxidizers. Incompatibilities with Other Materials: Acids, amines, ethylene oxide, halogens, permanganates, sulfuric acid, oxygen, isocyanates, hydrogen peroxides, acetaldehyde, halogenated organics (e.g. dibromoethane, hexachlorobenzene, methyl chloride, trichloroethylene), ketones (e.g. acetone, acetophenone, MEK, MIBK), acid anhydrides, oleum, chromium trioxide, alkalies, chlorine, carbony dichloride(phosgene), iron salts, perchloric acid, potassium-tert-butoxide, moisture, Attacks some forms of plastics, rubbers, and coatings., aluminum isopropoxide + crotonaldehyde + heat, trinitiromethane, barium perchlorate, dioxygenyl tetrafluoroborate, sodium dichromate + sulfuric acid, hydrogen + palladium, urea formaldehyde, aldehydes, hexamethylene diisocyanate, hypochlorous acid, aluminum at high temperatures. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 67-63-0: NT8050000 LD50/LC50: CAS# 67-63-0: Draize test, rabbit, eye: 100 mg Severe; Draize test, rabbit, eye: 10 mg Moderate; Draize test, rabbit, eye: 100 mg/24H Moderate; Draize test, rabbit, skin: 500 mg Mild; Inhalation, rat: LC50 = 16000 ppm/8H; Oral, mouse: LD50 = 3600 mg/kg; Oral, rabbit: LD50 = 6410 mg/kg; Oral, rat: LD50 = 5045 mg/kg; Skin, rabbit: LD50 = 12800 mg/kg. Carcinogenicity: 2-Propanol - IARC: Group 3 carcinogen Epidemiology: Experimental teratogenic and reproductive effects have been reported for isopropanol. Early epidemiological studies have suggested an association between the strong acid manufacture of isopropyl alcohol and paranasal sinus cancer in workers. Teratogenicity: Oral, rat: TDLo = 8 gm/kg (female 6-15 day(s) after conception) Effects on Embryo or Fetus - fetotoxicity.; Oral, rat: TDLo = 32400 ug/kg (female 26 week(s) pre-mating) Effects on Embryo or Fetus - fetal death.; Inhalation, rat: TCLo = 7000 ppm/7H (female 1-19 day(s) after conception) Specific Developmental Abnormalities - musculoskeletal system. Reproductive Effects: Oral, rat: TDLo = 11340 mg/kg (female 45 day(s) pre-mating) Maternal Effects - menstrual cycle changes or disorders.; Oral, rat: TDLo = 5040 mg/kg (female 1-20 day(s) after conception) Fertility - litter size (e.g. # fetuses per litter; measured before birth). Neurotoxicity: No information available. Mutagenicity: Cytogenetic analysis: Inhalation, rat = 1030 ug/m3/16W (Intermittent). Other Studies: Standard Draize Test: Administration onto the skin (rabbit) = 500 mg (Mild). Standard Draize Test: Administration into the eye (rabbit) = 100 mg (Moderate). Standard Draize Test: Administration into the eye = 10 mg (Moderate). Standard Draize test: Administration into the eye (rabbit) = 100 mg/24H (Moderate). **** SECTION 12 - ECOLOGICAL INFORMATION **** Ecotoxicity: Fish: Goldfish: > 5000 mg/L; 24 Hr; Modified ASTM D 1345 bioassayFish: Fathead Minnow: 11,830 mg/L; 1 Hr; Static bioassay Other Dangerous to aquatic life in high concentrations. **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT Shipping Name: ISOPROPANOL Hazard Class: 3 UN Number: UN1219 Packing Group: II Canadian TDG Shipping Name: ISOPROPANOL Hazard Class: 3 UN Number: UN1219 **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 67-63-0 is listed on the TSCA inventory. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE 2-Propanol can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI F Risk Phrases: R 11 Highly flammable. R 36 Irritating to eyes. R 67 Vapors may cause drowsiness and dizziness. Safety Phrases: S 7 Keep container tightly closed. S 16 Keep away from sources of ignition - No smoking. S 24/25 Avoid contact with skin and eyes. S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. WGK (Water Danger/Protection) CAS# 67-63-0: 1 United Kingdom Occupational Exposure Limits CAS# 67-63-0: OES-United Kingdom, TWA 400 ppm TWA; 999 mg/m3 TWA CAS# 67-63-0: OES-United Kingdom, STEL 500 ppm STEL; 1250 mg/m3 STEL Canada CAS# 67-63-0 is listed on Canada's DSL List. CAS# 67-63-0 is listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 67-63-0: OEL-AUSTRALIA:TWA 400 ppm (980 mg/m3);STEL 500 ppm (1225 mg/m3) OEL-BELGIUM:TWA 400 ppm (985 mg/m3);STEL 500 ppm (1230 mg/m3) OEL-DENMARK:TWA 200 ppm (490 mg/m3);Skin OEL-FRANCE:STEL 400 ppm (980 mg/m3) OEL-GERMANY:TWA 400 ppm (980 mg/m3) OEL-JAPAN:STEL 400 ppm (980 mg/m3) OEL-THE NETHERLANDS:TWA 400 ppm (980 mg/m3);Skin OEL-THE PHILIPPINES:TWA 400 ppm (980 mg/m3) OEL-RUSSIA:STEL 400 ppm (10 mg/m3) OEL-SWEDEN:TWA 150 ppm (350 mg/m3);STEL 250 ppm (600 mg/m3) OEL-SWITZERLAND:TWA 400 ppm (980 mg/m3);STEL 800 ppm OEL-TURKEY:TWA 200 ppm (500 mg/m3) OEL-UNITED KINGDOM:TWA 400 ppm (980 mg/m3);STEL 500 ppm;Skin OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 7/23/1999 Revision #7 Date: 2/21/2001 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------