SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 08/OCT/2003 
Date Updated: 17/MAR/2003 
Version 1.2 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name 2-PROPYLPENTANOIC ACID, 98% 
Product Number 224251 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
2-PROPYLPENTANOIC ACID 99-66-1 202-777-3 
Formula C8H16O2 
Molecular Weight 144.21 AMU 
Synonyms Abbott 44090,Acetic acid, dipropyl-, 
Acido valproico (Spanish),Depakine,Depakote, 
Dipropylacetic acid,Di-n-propylacetic acid, 
n-Dipropylacetic acid, 
Di-n-propylessigsaure (German),Ergenyl, 
Kyselina 2-propylvalerova (Czech), 
2-Propylpentanoic acid,2-Propylvaleric acid, 
Valproate,Valproic acid,Valproic acid, 
2-Propylvaleric acid, Abbott 44090, Acetic acid, 
dipropyl-, Acido valproico (Spanish),Depakine, 
Depakote, Di-n-propylacetic acid, 
Di-n-propylessigsaure (German), 
Dipropylacetic acid, Ergenyl, 
Kyselina 2-propylvalerova (Czech), 
n-Dipropylacetic acid, Valproate 
3 - Hazards Identification 
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT 
May cause harm to the unborn child. Harmful if swallowed. 
Irritating to eyes, respiratory system and skin. 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If breathing becomes difficult, 
call a physician. 
AFTER SKIN CONTACT 
In case of contact, immediately wash skin with soap and copious 
amounts of water.
AFTER EYE CONTACT 
In case of contact with eyes, flush with copious amounts of 
water for at least 15 minutes. Assure adequate flushing by 
separating the eyelids with fingers. Call a physician. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician. 
5 - Fire Fighting Measures 
EXTINGUISHING MEDIA 
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam. 
SPECIAL RISKS 
Specific Hazard(s): Emits toxic fumes under fire conditions. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL 
Evacuate area. 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear self-contained breathing apparatus, rubber boots, and heavy 
rubber gloves. 
METHODS FOR CLEANING UP 
Absorb on sand or vermiculite and place in closed containers for 
disposal. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Do not breathe vapor. Avoid 
contact with eyes, skin, and clothing. Avoid prolonged or 
repeated exposure. 
STORAGE 
Conditions of Storage: Keep tightly closed. 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Safety shower and eye bath. Mechanical exhaust required. 
GENERAL HYGIENE MEASURES 
Wash thoroughly after handling. 
PERSONAL PROTECTIVE EQUIPMENT 
Respiratory Protection: Government approved respirator. 
Hand Protection: Compatible chemical-resistant gloves. 
Eye Protection: Chemical safety goggles. 
9 - Physical and Chemical Properties 
Appearance Physical State: Liquid 
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Property Value At Temperature or Pressure 
pH N/A 
BP/BP Range 220 °C 760 mmHg 
MP/MP Range N/A 
Flash Point 111 °C Method: closed cup 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
SG/Density 0.907 g/cm3 
Partition Coefficient Log Kow: 2.75 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. N/A 
Solvent Content N/A 
Water Content N/A 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility Solubility in Water:Slightly. 2 mg/ml H2O 
Other Solvents: METHANOL, CHLOROFORM, ETHER 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Materials to Avoid: Bases, Oxidizing agents, Reducing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: YV7875000 
ACUTE TOXICITY 
LDLO 
Oral 
Man 
736 mg/kg 
Remarks: Brain and Coverings:Other degenerative changes. Lungs, 
Thorax, or Respiration:Acute pulmonary edema. 
LD50 
Oral 
Rat 
670 mg/kg 
Remarks: Behavioral:Somnolence (general depressed activity). 
Gastrointestinal:Hypermotility, diarrhea. 
LD50 
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Oral 
Mouse 
1098 mg/kg 
LD50 
Intraperitoneal 
Mouse 
470 MG/KG 
LD50 
Subcutaneous 
Mouse 
860 MG/KG 
LD50 
Intraperitoneal 
Rabbit 
1200 MG/KG 
LD50 
Oral 
Guinea pig 
824 mg/kg 
SIGNS AND SYMPTOMS OF EXPOSURE 
Symptoms of exposure may include burning sensation, coughing, 
wheezing, laryngitis, shortness of breath, headache, nausea, and 
vomiting. 
ROUTE OF EXPOSURE 
Skin Contact: Causes skin irritation. 
Skin Absorption: May be harmful if absorbed through the skin. 
Eye Contact: Causes eye irritation. 
Inhalation: May be harmful if inhaled. Material is irritating to 
mucous membranes and upper respiratory tract. 
Ingestion: Harmful if swallowed. 
TARGET ORGAN INFORMATION 
Liver. Nerves. Blood. 
CHRONIC EXPOSURE - TERATOGEN 
Result: May cause congenital malformation in the fetus. 
Species: Woman 
Dose: 5480 MG/KG 
Route of Application: Oral 
Exposure Time: (1-39W PREG) 
Result: Specific Developmental Abnormalities: Craniofacial 
(including nose and tongue). Specific Developmental 
Abnormalities: Musculoskeletal system. Specific Developmental 
Abnormalities: Cardiovascular (circulatory) system. 
Species: Woman 
Dose: 720 MG/KG 
Route of Application: Oral 
Exposure Time: (1-90D PREG) 
Result: Specific Developmental Abnormalities: Central nervous 
system. 
Species: Woman 
Dose: 126 GM/KG 
Route of Application: Unreported 
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Exposure Time: (1-18W PREG) 
Result: Specific Developmental Abnormalities: Musculoskeletal 
system. 
Species: Woman 
Dose: 5320 MG/KG 
Route of Application: Unreported 
Exposure Time: (2-39W PREG) 
Result: Specific Developmental Abnormalities: Central nervous 
system. Specific Developmental Abnormalities: Eye, ear. Specific 
Developmental Abnormalities: Craniofacial (including nose and 
tongue). 
Species: Woman 
Dose: 5320 MG/KG 
Route of Application: Unreported 
Exposure Time: (2-39W PREG) 
Result: Specific Developmental Abnormalities: Skin and skin 
appendages. Specific Developmental Abnormalities: 
Musculoskeletal system. Specific Developmental Abnormalities: 
Cardiovascular (circulatory) system. 
Species: Rat 
Dose: 2400 MG/KG 
Route of Application: Oral 
Exposure Time: (7-18D PREG) 
Result: Specific Developmental Abnormalities: Central nervous 
system. 
Species: Rat 
Dose: 6 GM/KG 
Route of Application: Oral 
Exposure Time: (8-17D PREG) 
Result: Specific Developmental Abnormalities: Musculoskeletal 
system. Specific Developmental Abnormalities: Cardiovascular 
(circulatory) system. Specific Developmental Abnormalities: 
Urogenital system. 
Species: Rat 
Dose: 660 MG/KG 
Route of Application: Subcutaneous 
Exposure Time: (10D PREG) 
Result: Effects on Embryo or Fetus: Cytological changes 
(including somatic cell genetic material). Effects on Embryo or 
Fetus: Fetotoxicity (except death, e.g., stunted fetus). 
Specific Developmental Abnormalities: Other developmental 
abnormalities. 
Species: Mouse 
Dose: 1500 MG/KG 
Route of Application: Oral 
Exposure Time: (6-15D PREG) 
Result: Specific Developmental Abnormalities: Musculoskeletal 
system. 
Species: Mouse 
Dose: 432 MG/KG 
Route of Application: Intraperitoneal 
Exposure Time: (8-10D PREG) 
Result: Effects on Embryo or Fetus: Fetotoxicity (except death, 
e.g., stunted fetus). Specific Developmental Abnormalities: 
Musculoskeletal system. 
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Species: Mouse 
Dose: 519 MG/KG 
Route of Application: Intraperitoneal 
Exposure Time: (8-10D PREG) 
Result: Specific Developmental Abnormalities: Central nervous 
system. 
Species: Mouse 
Dose: 2400 MG/KG 
Route of Application: Subcutaneous 
Exposure Time: (7-14D PREG) 
Result: Effects on Embryo or Fetus: Fetotoxicity (except death, 
e.g., stunted fetus). Effects on Embryo or Fetus: Fetal death. 
Specific Developmental Abnormalities: Central nervous system. 
Species: Mouse 
Dose: 600 MG/KG 
Route of Application: Unreported 
Exposure Time: (8D PREG) 
Result: Specific Developmental Abnormalities: Other 
developmental abnormalities. 
Species: Monkey 
Dose: 18 GM/KG 
Route of Application: Oral 
Exposure Time: (21-50D PREG) 
Result: Effects on Embryo or Fetus: Fetal death. 
Species: Rabbit 
Dose: 4550 MG/KG 
Route of Application: Oral 
Exposure Time: (6-18D PREG) 
Result: Specific Developmental Abnormalities: Body wall. 
Specific Developmental Abnormalities: Musculoskeletal system. 
Specific Developmental Abnormalities: Cardiovascular 
(circulatory) system. 
Species: Rabbit 
Dose: 1950 MG/KG 
Route of Application: Oral 
Exposure Time: (6-18D PREG) 
Result: Effects on Embryo or Fetus: Fetotoxicity (except death, 
e.g., stunted fetus). 
Species: Rabbit 
Dose: 945 MG/KG 
Route of Application: Unreported 
Exposure Time: (6-8D PREG) 
Result: Specific Developmental Abnormalities: Urogenital system. 
Species: Hamster 
Dose: 300 MG/KG 
Route of Application: Intraperitoneal 
Exposure Time: (7D PREG) 
Result: Specific Developmental Abnormalities: Central nervous 
system. 
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD 
Species: Woman 
Dose: 6525 MG/KG 
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Route of Application: Oral 
Exposure Time: (26W PRE/1-36W PREG) 
Result: Effects on Newborn: Growth statistics (e.g., reduced 
weight gain). Effects on Newborn: Biochemical and metabolic. 
Effects on Newborn: Physical. 
Species: Woman 
Dose: 2394 MG/KG 
Route of Application: Unreported 
Exposure Time: (1-36W PREG) 
Result: Effects on Newborn: Apgar score (human only). 
Species: Woman 
Dose: 2047 MG/KG 
Route of Application: Unreported 
Exposure Time: (27-40W PREG) 
Result: Effects on Newborn: Physical. 
Species: Woman 
Dose: 5320 MG/KG 
Route of Application: Unreported 
Exposure Time: (2-39W PREG) 
Result: Effects on Newborn: Weaning or lactation index (e.g., # 
alive at weaning per # alive at day 4). 
Species: Rat 
Dose: 24500 MG/KG 
Route of Application: Oral 
Exposure Time: (7W MALE) 
Result: Paternal Effects: Spermatogenesis (including genetic 
material, sperm morphology,motility, and count). Paternal 
Effects: Testes, epididymis, sperm duct. Paternal Effects: 
Prostate, seminal vessicle, Cowper's gland, accessory glands. 
Species: Rat 
Dose: 600 MG/KG 
Route of Application: Oral 
Exposure Time: (13D PREG) 
Result: Effects on Fertility: Post-implantation mortality (e.g., 
dead and/or resorbed implants per total number of implants). 
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., 
stunted fetus). 
Species: Rat 
Dose: 34 GM/KG 
Route of Application: Oral 
Exposure Time: (60D MALE/2W PRE-1D POST) 
Result: Effects on Newborn: Viability index (e.g., # alive at 
day 4 per # born alive). Effects on Newborn: Growth statistics 
(e.g., reduced weight gain). 
Species: Mouse 
Dose: 432 MG/KG 
Route of Application: Intraperitoneal 
Exposure Time: (11-13D PREG) 
Result: Effects on Fertility: Post-implantation mortality (e.g., 
dead and/or resorbed implants per total number of implants). 
Effects on Embryo or Fetus: Fetal death. 
Species: Mouse 
Dose: 600 MG/KG 
Route of Application: Intraperitoneal 
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Exposure Time: (9D PREG) 
Result: Effects on Fertility: Post-implantation mortality (e.g., 
dead and/or resorbed implants per total number of implants). 
Species: Mouse 
Dose: 400 MG/KG 
Route of Application: Unreported 
Exposure Time: (7D PREG) 
Result: Maternal Effects: Other effects. 
Species: Rabbit 
Dose: 4550 MG/KG 
Route of Application: Oral 
Exposure Time: (6-18D PREG) 
Result: Effects on Fertility: Post-implantation mortality (e.g., 
dead and/or resorbed implants per total number of implants). 
Specific Developmental Abnormalities: Central nervous system. 
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Contact a licensed professional waste disposal service to dispose 
of this material. Dissolve or mix the material with a combustible 
solvent and burn in a chemical incinerator equipped with an 
afterburner and scrubber. Observe all federal, state, and local 
environmental regulations. 
14 - Transport Information 
RID/ADR 
Non-hazardous for road transport. 
IMDG 
Non-hazardous for sea transport. 
IATA 
Non-hazardous for air transport. 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
INDICATION OF DANGER: T 
Toxic. 
R-PHRASES: 61 22 36/37/38 
May cause harm to the unborn child. Harmful if swallowed. 
Irritating to eyes, respiratory system and skin. 
S-PHRASES: 26 36/37/39 45 53 23 
In case of contact with eyes, rinse immediately with plenty of 
water and seek medical advice. Wear suitable protective 
clothing, gloves, and eye/face protection. In case of accident 
or if you feel unwell, seek medical advice immediately (show 
the label where possible). Avoid exposure - obtain special 
instructions before use. Do not breathe vapor. 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
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purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
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