Material Safety Data Sheet 5-Fluorouracil, 99% ACC# 90247 Section 1 - Chemical Product and Company Identification MSDS Name: 5-Fluorouracil, 99% Catalog Numbers: AC228440000, AC228440010, AC228440050 Synonyms: 5-Fluoro-2,4(1H,3H)-pyrimidinedione Company Identification: Acros Organics N.V. One Reagent Lane Fair Lawn, NJ 07410 For information in North America, call: 800-ACROS-01 For emergencies in the US, call CHEMTREC: 800-424-9300 Section 2 - Composition, Information on Ingredients CAS#Chemical NamePercentEINECS/ELINCS 51-21-85-Fluorouracil, 99%99% 200-085-6 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: white solid. Warning! Harmful. Harmful if swallowed. Causes eye and skin irritation. Causes digestive and respiratory tract irritation. May cause adverse reproductive effects. Light sensitive. Target Organs: None. Potential Health Effects Eye: May cause eye irritation. Skin: Causes skin irritation. Harmful if absorbed through the skin. Ingestion: Harmful if swallowed. Causes gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Harmful if inhaled. Causes respiratory tract irritation. Chronic: Prolonged or repeated exposure may cause adverse reproductive effects. Section 4 - First Aid Measures Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, or carbon dioxide. Flash Point: 280 deg C ( 536.00 deg F) Autoignition Temperature: Not available. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 2; Flammability: 1; Instability: 0 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - Handling and Storage Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Store protected from light. Use only in a chemical fume hood. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Exposure Limits Chemical NameACGIHNIOSHOSHA - Final PELs 5-Fluorouracil, 99%none listed none listed none listed OSHA Vacated PELs: 5-Fluorouracil, 99%: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear chemical splash goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear a chemical apron. Respirators: A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149. Section 9 - Physical and Chemical Properties Physical State: Solid Appearance: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point:280 - 282 deg C Decomposition Temperature:280 deg C Solubility: slightly soluble Specific Gravity/Density:Not available. Molecular Formula:C4H3FN2O2 Molecular Weight:130.08 Section 10 - Stability and Reactivity Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Light. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride gas. Hazardous Polymerization: Has not been reported. Section 11 - Toxicological Information RTECS#: CAS# 51-21-8: YR0350000 LD50/LC50: CAS# 51-21-8: Oral, mouse: LD50 = 115 mg/kg; Oral, rabbit: LD50 = 18900 ug/kg; Oral, rat: LD50 = 230 mg/kg; Carcinogenicity: CAS# 51-21-8: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: No data available. Teratogenicity: No data available. Reproductive Effects: No data available. Mutagenicity: No data available. Neurotoxicity: No data available. Other Studies: Section 12 - Ecological Information No information available. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. Section 14 - Transport Information US DOTCanada TDG Shipping Name:Please contact Fisher Scientific for shipping informationNo information available. Hazard Class: UN Number: Packing Group: Section 15 - Regulatory Information US FEDERAL TSCA CAS# 51-21-8 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs None of the chemicals in this material have an RQ. SARA Section 302 Extremely Hazardous Substances CAS# 51-21-8: 500 lb TPQ (lower threshold); 10000 lb TPQ (upper thresh old) Section 313 This material contains 5-Fluorouracil, 99% (CAS# 51-21-8, 99%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 51-21-8 can be found on the following state right to know lists: New Jersey, Pennsylvania, Massachusetts. California Prop 65 WARNING: This product contains 5-Fluorouracil, 99%, a chemical known to the state of California to cause developmental reproductive toxicity. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. Safety Phrases: S 36/37 Wear suitable protective clothing and gloves. WGK (Water Danger/Protection) CAS# 51-21-8: 2 Canada - DSL/NDSL CAS# 51-21-8 is listed on Canada's NDSL List. Canada - WHMIS WHMIS: Not available. Canadian Ingredient Disclosure List Section 16 - Additional Information MSDS Creation Date: 9/02/1997 Revision #3 Date: 3/18/2003 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.