Revision Date: 04/11/2001 PRODUCT NAME: MATERIAL SAFETY DATA SHEET PRODUCT NUMBER: EC-850 AccuGel 19:1 - 40% Aqueous solution of acrylamides. MANUFACTURER: National Diagnostics, Inc 305 Patton Drive Atlanta, GA 30336 1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION CHEMICAL NAMES/ DESCRIPTION: TELEPHONE NUMBER: (800) 526-3867 (404) 699-2121 EMERGENCY NUMBER: CHEMTREC (800) 424-9300 3. HAZARDS IDENTIFICATION APPEARANCE AND ODOR: EMERGENCY OVERVIEW - IMMEDIATE HAZARD WARNING! HARMFUL IF SWALLOWED. MAY CAUSE ALLERGIC SKIN REACTION. MAY CAUSE EYE IRRITATION. POLYMERIZATION MY OCCUR FROM EXCESSIVE HEAT OR CONTAMINATION. EMERGENCY OVERVIEW - CHRONIC HAZARD WARNING CHRONIC TOXICITY HAZARD. ACRYLAMIDE MAY CAUSE NERVOUS SYSTEM DAMAGE. ACRYLAMIDE CAUSED CANCER AND MALE REPRODUCTIVE DISORDERS IN LABORATORY ANIMAL TESTS. RISK DEPENDS ON DURATION AND LEVEL OF EXPOSURE. INHALATION POTENTIAL HEALTH EFFECTS Inhalation of mist causes irritation to the respiratory tract. Symptoms may parallel ingestion. INGESTION Toxic! May cause systemic poisoning. May cause drowsiness, tingling sensations, fatigue, weakness, stumbling, slurred speech, and shaking. May cause central and peripheral nervous system damage. Severe intoxication may cause permanent nerve damage. May affect reproductive system and act as a teratogen. SKIN May cause irritation and redness. Can be absorbed through the skin causing systemic poisoning; symptoms may parallel ingestion. EYES Acrylamide solutions may cause eye irritation. 2. COMPOSITION / INFORMATION ON INGREDIENTS Component ACRYLAMIDE BIS-ACRYLAMIDE EEC LABEL SYMBOL AND CLASSIFICATION % Comp CAS # EINECS # 79-06-1 < 40 203-750-9 110-26-9 < 10 R: 45-46-24/25-48/23/24/25 Clear, colorless solution. Page 1 TLV (units) 201-173-7 0.03 mg/m3 (TWA) (skin) for solid 5 mg/m3 (TWA) (skin) for solid May cause cancer. May cause heritable genetic damage. Also toxic in contact with skin and if swallowed. Danger of serious damage to health by prolonged exposure through inhalation, in contact with skin or if swallowed. S: 53-45 Avoid exposure, obtain special instructions before use. In case of accident or if you feel ill, seek medical advice immediately (show the label where possible). AccuGel 19:1 - 40% INHALATION 4. FIRST AID MEASURES INHALATION: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician. INGESTION: Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Call a physician. SKIN: Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse. EYES: Immediately flush eyes with plenty of water for at least fifteen minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately. 5. FIRE FIGHTING MEASURES N.A. FLASH POINT: N.A. SIGNS AND SYMPTOMS 0F OVEREXPOSURE Contact with this material by inhalation of mist may cause nervous system effects. See ingestion effects for more details. INGESTION Contact with this material by any route (eyes/skin, inhalation or ingestion) may cause nervous system effects (neurotoxicity). These effects can result from a single overexposure but are more likely to occur after repeated exposures to small amounts over a period of several days or weeks. Signs and symptoms of toxic effects include increased sweating of the hands and feet, numbness, tingling and weakness in the extremeties, unsteady gait and decreased reflexes SKIN Acrylamide is readily absorbed through unbroken skin. If the exposure route is dermal, the signs and symptoms described above under 'Signs and Symptoms of Overexposure - Ingestion' may be preceded by peeling and redness of skin at the areas of exposure, normally the hands and feet. EYES Contact with this material by eyes may cause nervous system effects. See 'Signs and Symptoms of Overexposure - Ingestion' above for more details. CARCINOGENICITY Acrylamide is suspected as a cancer hazard. May cause cancer. Listed by NTP as a suspected carcinogen. Acrylamide is known to the State of California to cause cancer. MUTAGENICITY Acrylamide was negative in the Ames assay both with and without metabolic activation. REPRODUCTIVE TOXICITY Acrylamide induced male reproductive toxicity has been demonstrated in Long-Evans rats where given greater than or equal to 15 mg/kg/day acrylamide orally by gavage for five consecutive days. In this study, males receiving greater than or equal to 15 mg/kg/day acrylamide had a reduced fertility index. TERATOGENIC EFFECTS Not Available. ROUTES OF ENTRY Contact with this material by any route of exposure (eye/skin, inhalation or ingestion) may cause serious adverse health consequences. TARGET ORGAN STATEMENT Not Available. FLAMMABLE LIMITS: Page 2 AccuGel 19:1 - 40% AUTOIGNITION TEMPERATURE: FLASH POINT METHOD: N.A. N.A. EXTINGHISHING MEDIA Use media appropriate to the primary cause of fire. PROTECTIVE EQUIPMENT In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. HAZARDOUS COMBUSTION PRODUCTS: Thermal decomposition products may include carbon monoxide, carbon dioxide, and hydrocarbons. UNUSUAL FIRE AND EXPLOSION HAZARDS N.A. 2 1 Flammability: Reactivity:1 NFPA CODES: Health: 6. ACCIDENTAL RELEASE MEASURES STEPS TO BE TAKEN IN CASE MATERIAL IS RELEASED OR SPILLED Contain and clean up spill immediately, prevent from entering floor drains. Contain liquids using absorbents. Shovel all spill materials into disposal drum. Scrub spill area with detergent, flush with copious amounts of water. WASTE DISPOSAL METHOD Disposal must be made in accordance with applicable federal, state, and local regulations. PERSONAL PRECAUTIONS If water solvent has evaporated, wear NIOSH approved air-purifying respirator. 7. HANDLING AND STORAGE HANDLING Avoid contact and inhalation. Do not get in eyes, on skin, on clothing. Wash thoroughly after handling. Wear special protective equipment (Sec. 8) where exposures may exceed established levels. STORAGE Keep in a tightly closed container, stored in a cooled, dry, ventilated area. Protect from physical damage. Isolate from incompatible materials (section 10). STORAGE TEMPERATURE: (20 C) DISPOSAL Observe all national, state, and local regulations regarding product disposal. Containers of this material may be hazardous when empty since they retain product residues (dust, solids). 8. EXPOSURE CONTROLS / PERSONAL PROTECTION AIRBORNE EXPOSURE LIMITS: Component: ACRYLAMIDE 0.03 mg/m3 (TWA) (skin) for solid ACGIH Threshold Limit Value (TLV): 0.3 mg/m3 (TWA) (skin) for solid OSHA Permissible Exposure Limit (PEL): ENGINEERING CONTROLS A system of local and/or general exhaust is recommended to keep employee exposures below the Airborn Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source. RESPIRATORY PROTECTION If exposure limits are exceeded, wear a full-face respirator with organic vapor cartridge and high efficiency dust mist filter. Beyond fifty times exposure limits or when exposure levels are not known, wear a full-face piece positive pressure respirator. Page 3 AccuGel 19:1 - 40% EYE PROTECTION Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area. SKIN PROTECTION Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact. OTHER CONTROL MEASURES Weekly examinations for skin peeling of hands and fingers. Comments: Stress good personal cleanliness and housekeeping to prevent skin contact. Wear clean work clothing daily. Do not home launder. 1.0 Evaporation Rate Soluble Solubility in Water Neutral pH 1.07 Specific Gravity (H20 = 1) 9. PHYSICAL PROPERTIES 220 F Boiling Point N.A. Melting Point Water Vapor Pressure mm Hg Vapor Density N.A. Air = 1 60 % Volatile by Volume 10. STABILITY AND REACTIVITY STABILITY Stable under ordinary conditions of use and storage. CONDITIONS TO AVOID Heat, shock, UV light, and incompatibles. HAZARDOUS DECOMPOSITION PRODUCTS Upon heating, may produce carbon dioxide, carbon monoxide, and hydrogen. HAZARDOUS POLYMERIZATION May occur INCOMPATIBLES ACRYLAMIDE Acrylamide reacts with acids, oxidizing agents, and bases. Spontaneously reacts with hydroxyl-, amino-, and sulfhydryl- containing compounds. Avoid vinyl polymerization initiators or contamination with aluminum, iron, copper, brass, and bronze. BIS-ACRYLAMIDE Strong bases, strong acids, and oxidizing agents. 500 2185 NTP Carcinogen Anticipated IARC Category Known 2A Yes No 11. TOXICOLOGICAL INFORMATION Oral Rat LD50 (mg/kg): Dermal Rabbit LD50 (mg/kg): PRODUCT LD50 VALUES AccuGel 19:1 - 40% AccuGel 19:1 - 40% COMPONENT CANCER LIST STATUS Component ACRYLAMIDE BIS-ACRYLAMIDE None No No 12. ECOLOGICAL INFORMATION ACRYLAMIDE When pure acrylamide is released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this material is expected to leach into groundwater. This material is not expected to significantly bioaccumulate. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition. AccuGel 19:1 - 40% Page 4 BIS-ACRYLAMIDE No information found. 13. DISPOSAL CONSIDERATIONS Observe all national, state, and local regulations regarding product disposal. Containers of this material may be hazardous when empty since they retain product residues (dust, solids). 14. TRANSPORT INFORMATION Domestic (D.O.T.) Toxic Liquid, Organic, N.O.S. Proper Shipping Name: Hazard Class: 6.1 UN Number: 2810 Packing Group: III International (I.A.T.A. / I.M.O.) Proper Shipping Name: Toxic Liquid, Organic, N.O.S. Hazard Class: 6.1 UN Number: 2810 Packing Group: III 15. REGULATORY INFORMATION UNITED STATES TSCA Regulatory: All intentional ingredients are listed on the TSCA Inventory. SARA 311/312 Hazard Categories Component ACRYLAMIDE BIS-ACRYLAMIDE EUROPE EEC Regulatory: All intentional ingredients are listed on the European EINECS Inventory. EEC LABEL SYMBOL AND CLASSIFICATION R: 45-46-24/25-48/23/24/25 May cause cancer. May cause heritable genetic damage. Also toxic in contact with skin and if swallowed. Danger of serious damage to health by prolonged exposure through inhalation, in contact with skin or if swallowed. S: 53-45 Avoid exposure, obtain special instructions before use. In case of accident or if you feel ill, seek medical advice immediately (show the label where possible). 16. OTHER INFORMATION 2 1 Flammability: Reactivity:1 NFPA CODES: Health: MANUFACTURER DISCLAIMER: The information given herein is offered in good faith as accurate, but without guarantee. Conditions of use and suitability of the product for particular uses are beyond our control. All risks of use of the product are therefore assumed by the user. Nothing is intended as a recommendation for uses which infringe valid patents or as extending license under valid patents. Appropriate warnings and safe handling procedures should be provided to handlers and users. Chronic Acute Pressure Reactivity Fire Yes Yes No No No Yes Yes No No No AccuGel 19:1 - 40% Page 5