Material Safety Data Sheet **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: Acetic anhydride Catalog Numbers: AC400060000, AC400060010, AC400060040, S70072, S70078, S71903, A10 1, A10 100, A10 4, A10 500, A10-1, A10-100, A10-4, A10-500, A101, A10100, A104 A10500, A10J4, NC9556617, XXA10207LI Synonyms: Acetic oxide; Acetyl oxide; Ethanoic anhydride; Acetic acid anhydride. Company Identification: Fisher Scientific 1 Reagent Lane Fairlawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 108-24-7 |Acetic anhydride | > 97.0 | 203-564-8 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: C Risk Phrases: 10 20/22 34 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Flammable. Harmful by inhalation and if swallowed. Causes burns.Corrosive.Moisture sensitive. Potential Health Effects Eye: Eye damage may be delayed. Contact with liquid is corrosive to the eyes and causes severe burns. When substance becomes wet or comes in contact with moisture of the mucous membranes, it will cause irritation. May cause chemical conjunctivitis and corneal damage. Skin: Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. Prolonged skin contact may be painless with reddening of the skin followed be a white appearance of the skin. Skin burns may be delayed. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color. Ingestion: May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May be harmful if swallowed. Ingestion of large amounts may cause CNS depression. May cause systemic effects. Inhalation: Harmful if inhaled. Causes severe irritation of upper respiratory tract with coughing, burns, breathing difficulty, and possible coma. Causes chemical burns to the respiratory tract. May cause lung damage. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest. Chronic: Effects may be delayed. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes). Skin: Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Discard contaminated clothing in a manner which limits further exposure. If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Containers may explode in the heat of a fire. Flammable liquid and vapor. May ignite or explode on contact with steam or moist air. Extinguishing Media: Use dry sand or earth to smother fire. If water is the only media available, use in flooding amounts. DO NOT USE WATER! Do NOT use straight streams of water. Contact professional fire-fighters immediately. Cool containers with flooding quantities of water until well after fire is out. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water. Spill may be neutralized with lime. Cover with material such as dry soda ash or calcium carbonate and place into a closed container for disposal. A vapor suppressing foam may be used to reduce vapors. **** SECTION 7 - HANDLING and STORAGE **** Handling: Remove contaminated clothing and wash before reuse. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Use with adequate ventilation. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Do not store in direct sunlight. Keep container closed when not in use. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from water. Flammables-area. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local explosion-proof ventilation to keep airborne levels to acceptable levels. Personal Protective Equipment Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR :1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Liquid Appearance: colorless liquid Odor: strong odor - pungent odor - acetic odor pH: Not available. Vapor Pressure: 3.9 mm Hg @68F Vapor Density: 3.5 (air=1) Evaporation Rate: 0.46 (n-butyl acetate=1) Viscosity: Not available. Boiling Point: 137 deg C Freezing/Melting Point: Not available. Autoignition Temperature: 630 deg F ( 332.22 deg C) Flash Point: 126 deg F ( 52.22 deg C) Explosion Limits, lower: 2.9% Explosion Limits, upper: 10.3% Decomposition Temperature: Solubility: Decomposes. Specific Gravity/Density: 1.0820g/cm3 Molecular Formula: C4H6O3 Molecular Weight: 102.09 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable. However, may decompose if exposed to moist air or water. Substance is readily hydrolyzed. Reacts with water to form corresponding acid. Conditions to Avoid: Ignition sources, contact with water, excess heat, exposure to moist air or water. Incompatibilities with Other Materials: Alcohols, moisture, bases, strong oxidizing agents, strong reducing agents, metal powders. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 108-24-7: AK1925000 LD50/LC50: CAS# 108-24-7: Inhalation, rat: LC50 = 1000 ppm/4H; Oral, rat: LD50 = 1780 mg/kg; Skin, rabbit: LD50 = 4 mL/kg. Carcinogenicity: Acetic anhydride - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: No information found. Teratogenicity: No information found. Reproductive Effects: No information found. Neurotoxicity: No information found. Mutagenicity: No information found. Other Studies: See actual entry in RTECS for complete information. **** SECTION 12 - ECOLOGICAL INFORMATION **** Other For more information, see "HANDBOOK OF ENVIRONMENTAL FATE AND EXPOSURE DATA." **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT Shipping Name: ACETIC ANHYDRIDE Hazard Class: 8 UN Number: UN1715 Packing Group: II Canadian TDG Shipping Name: ACETIC ACID SOLUTION Hazard Class: 8(9.2) UN Number: UN2790 **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 108-24-7 is listed on the TSCA inventory. This material does not contain any Class 2 Ozone depletors. Clean Water Act: CAS# 108-24-7 is listed as a Hazardous Substance under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Acetic anhydride can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: C Risk Phrases: R 10 Flammable. R 20/22 Harmful by inhalation and if swallowed. R 34 Causes burns. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 108-24-7: 1 United Kingdom Occupational Exposure Limits CAS# 108-24-7: OES-United Kingdom, TWA 0.5 ppm TWA; 0.1 mg/m3 TWA CAS# 108-24-7: OES-United Kingdom, STEL 2 ppm STEL; 0.4 mg/m3 STEL Canada CAS# 108-24-7 is listed on Canada's DSL List. CAS# 108-24-7 is listed on Canada's Ingredient Disclosure List. Exposure Limits **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 10/09/1998 Revision #10 Date: 1/03/2001 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------