Material Safety Data Sheet **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: Acetonitrile Catalog Numbers: S70092ACS, S70092HPLC, A21 1, A21 20, A21 4, A21 SS115, A21-1, A21-20, A21-4, A21-500, A211, A2120, A21200, A2120LC, A214, A214LC, A21RB115, A21RB19, A21RB200, A21RB50, A21RS115, A21RS200, A21RS28, A21SK-4, A21SS 200 A21SS 30, A21SS 50, A21SS115, A21SS200, A21SS30, A21SS50, A24-4, A996 1, A996 4, A996-1, A996-4, A9961, A9964, A9964LC, A9964LOT004, A9964LOT005, A9964LOT006, A9964LOT008, A996RS115, A996RS19, A996RS200, A996RS28, A996RS50, A996SS115, A996SS200, A996SS28, A996SS50, A998 1, A998 4, A998-1, A998-4, A9981, A9984, A9984LC, A9984LOT002, A998RS115, A998RS19, A998RS200, A998RS28, A998RS50, A998S S115, A998S S30, A998S S50, A998SK 1, A998SK 4, A998SK-1, A998SK-4, A998SK1, A998SK4, A998SK4001, A998SK4LC, A998SS 200, A998SS-11, A998SS-115, A998SS-20, A998SS-200, A998SS-30, A998SS-50, A998SS115, A998SS200, A998SS28, A998SS30, A998SS50, A999 4, A999-4, A9994, BP1165 50, BP1165-50, BP116550, BP1170 4, BP1170 4002, BP1170 4004, BP1170 4005, BP1170 4006, BP1170 4007, BP1170 4008, BP1170 4009, BP1170 4010, BP1170-4, BP11704, BP11704002, BP11704004, BP11704005, BP11704006, BP11704007, BP11704008, BP11704009, BP11704010, BP1170450, BP1170RS115, BP1170RS19, BP1170RS200, BP1170RS28, BP1170RS50, BP1170SS 115, BP1170SS 200, BP1170SS 30, BP1170SS 50, BP1170SS-11, BP1170SS-20, BP1170SS-30, BP1170SS-50, BP1170SS115, BP1170SS200, BP1170SS28, BP1170SS30, BP1170SS50, BP11744, BP1174OLC, BP1406LC, BP2405, BP2600-100, BW1140RT50, CRNBP11704, FLA21RB-115, FLA21RB-19, FLA21RB-200, FLA21RB-50, FLA21RS-115, FLA21RS-200, FLA21RS-28, FLA21RS-50, NC9708859, NC9766430, O1034 500, O1034-500, O1034500, XXA998U20LI Synonyms: Cyanomethane; Ethanenitrile; Ethyl nitrile; Methyl cyanide. Company Identification: Fisher Scientific 1 Reagent Lane Fairlawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 75-05-8 |Acetonitrile | ca. 100 | 200-835-2 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: T F Risk Phrases: 11 23/24/25 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Highly flammable. Toxic by inhalation, in contact with skin and if swallowed.Lachrymator.Hygroscopic. Potential Health Effects Eye: Causes eye irritation. Lachrymator. May produce superficial reversible injury. Skin: Causes mild skin irritation. Harmful if absorbed through the skin. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause effects similar to those for inhalation exposure. May cause tissue anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis, weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. May cause central nervous system depression. Metabolism may release cyanide, which may result in headache, dizziness, weakness, collapse, unconsciousness and possible death. Inhalation: Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. Causes upper respiratory tract irritation. May be metabolized to cyanide which in turns act by inhibiting cytochrome oxidase impairing cellular respiration. May cause tissue anoxia, characterized by weakness, headache, dizziness, confusion, cyanosis, weak and irregular heart beat, collapse, unconsciousness, convulsions, coma and death. Chronic: Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. May cause liver and kidney damage. May be metabolized to cyanide which in turn acts by inhibiting cytochrome oxidase impairing cellular respiration. Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen. Laboratory experiments have resulted in mutagenic effects. Exposure to small amounts of cyanide compounds over long periods of time is reported to cause loss of appetite, headache, weakness, nausea, dizziness, and symptoms of irritation of the upper respiratory tract and eyes. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Skin: Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Exposure should be treated as a cyanide poisoning. Effects may be delayed. For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood. May be partially metabolized to cyanide in the body. Antidote: Always have a cyanide antidote kit on hand when working with cyanide compounds. Get medical advice to use. Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia. **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. Vapors may form an explosive mixture with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Flammable liquid and vapor. Approach fire from upwind to avoid hazardous vapors and toxic decomposition products. Vapors are heavier than air and may travel to a source of ignition and flash back. Vapors can spread along the ground and collect in low or confined areas. Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. Do not use combustible materials such as saw dust. Provide ventilation. A vapor suppressing foam may be used to reduce vapors. Water spray may reduce vapor but may not prevent ignition in closed spaces. Approach spill from upwind. **** SECTION 7 - HANDLING and STORAGE **** Handling: Remove contaminated clothing and wash before reuse. Use only in a well-ventilated area. Ground and bond containers when transferring material. Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Store protected from moisture. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Personal Protective Equipment Eyes: Wear chemical goggles. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR :1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Liquid Appearance: clear, colorless Odor: sweetish odor - ethereal odor pH: Not available. Vapor Pressure: 73 mm Hg Vapor Density: 1.42 (Air=1) Evaporation Rate: 5.79 (Butyl acetate=1) Viscosity: 0.36 cP 20 deg Boiling Point: 82 deg C @ 760.00mm Hg Freezing/Melting Point: -50 deg C Autoignition Temperature: 524 deg C ( 975.20 deg F) Flash Point: 6 deg C ( 42.80 deg F) Explosion Limits, lower: 4.4 vol % Explosion Limits, upper: 16.00 vol % Decomposition Temperature: > 500 deg C Solubility: Miscible. Specific Gravity/Density: .7810g/cm3 Molecular Formula: C2H3N Molecular Weight: 41.04 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, ignition sources, excess heat, exposure to moist air or water, oxidizers. Incompatibilities with Other Materials: Oxidizing agents, reducing agents, acids, bases, alkali metals, fluorine, nitric acid, perchlorates, sulfuric acid, chlorosulfonic acid, oleum, dinitrogen tetraoxide, sulfites, indium, moisture, Attacks some forms of plastics, rubbers, and coatings., nitrating agents, N-fluoro compounds (e.g. perfluorourea + acetonitrile), lanthanide perchlorates, iron (III) perchlorate, 2-Cyano-2-propyl nitrate, trichlorosilane, diphenyl sulfoxide. Hazardous Decomposition Products: Hydrogen cyanide, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 75-05-8: AL7700000 LD50/LC50: CAS# 75-05-8: Inhalation, mouse: LC50 = 2693 ppm/1H; Inhalation, rabbit: LC50 = 2828 ppm/4H; Inhalation, rat: LC50 = 7551 ppm/8H; Oral, mouse: LD50 = 269 mg/kg; Oral, rabbit: LD50 = 50 mg/kg; Oral, rat: LD50 = 2460 mg/kg; Skin, rabbit: LD50 = 1250 uL/kg. Carcinogenicity: Acetonitrile - ACGIH: A4 - Not Classifiable as a Human Carcinogen Epidemiology: No information available. Teratogenicity: Embryo or Fetus-stunted fetus: Inhalation, hamster: TCLo=8000 ppm/1H (female 8 days after conception).; Specific Developmental Abnormalities - musculoskeletal: Oral, hamster TCLo = 300 mg/kg (female 8 days after conception). Reproductive Effects: Fertility - post-implantation mortality: Oral, hamster: TDLo=400 mg/kg and Inhalation, hamster TCLo=5000 ppm/1H (female 8 days after conception). Neurotoxicity: No information available. Mutagenicity: Sex Chromosome Loss/Non-disjunction: Saccharomyces cerevisiae = 47600 ppm and Drosophila melongaster = 131 ppm.; Sister Chromatid Exchange: Hamster, ovary = 5 gm/L.; Inhalation, rat: TDL0 = 400 ppm/6H/24-I (produced liver tumors) Other Studies: Open irritation test: Administration onto the skin (rabbit) = 500 mg (Mild). **** SECTION 12 - ECOLOGICAL INFORMATION **** Ecotoxicity: Fish: Fathead Minnow: 1150 ppm; 24 Hr; TLm (hard water)Fish: Fathead Minnow: 1000 mg/L; 96 Hr; TLm (soft water)Fish: Bluegill/Sunfish: 1850 mg/L; 96 Hr; TLm (soft water)Fish: Fathead Minnow: 1640 mg/L; 96 Hr; LC50 (flow-bioassay)Fish: Fathead Minnow: 1640 mg/L; 96 Hr; EC50 (flow-bioassay) Other Biodegradable. **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT Shipping Name: ACETONITRILE Hazard Class: 3 UN Number: UN1648 Packing Group: II Canadian TDG Shipping Name: ACETONITRILE Hazard Class: 3(6.1) UN Number: UN1648 Other Information: FLASHPOINT 6 C **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 75-05-8 is listed on the TSCA inventory. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Acetonitrile can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T F Risk Phrases: R 11 Highly flammable. R 23/24/25 Toxic by inhalation, in contact with skin and if swallowed. Safety Phrases: S 16 Keep away from sources of ignition - No smoking. S 27 Take off immediately all contaminated clothing. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 75-05-8: 2 United Kingdom Occupational Exposure Limits CAS# 75-05-8: OES-United Kingdom, TWA 40 ppm TWA; 68 mg/m3 TWA CAS# 75-05-8: OES-United Kingdom, STEL 60 ppm STEL; 102 mg/m3 STEL Canada CAS# 75-05-8 is listed on Canada's DSL List. CAS# 75-05-8 is listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 75-05-8: OEL-ARAB Republic of Egypt:TWA 40 ppm (70 mg/m3);Skin OEL-AUSTRALIA:TWA 40 ppm (70 mg/m3);STEL 60 ppm ;Skin OEL-AUSTRIA:TWA 40 ppm (70 mg/m3) OEL-BELGIUM:TWA 40 ppm (67 mg/m3);STEL 60 ppm (10 mg/m3);Skin OEL-DENMARK:TWA 40 ppm (70 mg/m3);STEL 60 ppm (10 mg/m3) OEL-FINLAND:TWA 40 ppm (70 mg/m3);STEL 60 ppm (10 mg/m3) OEL-FRANCE:TWA 40 ppm (70 mg/m3) OEL-GERMANY:TWA 40 ppm (70 mg/m3) OEL-HUNGARY:TWA 50 mg/m3;STEL 100 mg/m3;Skin JAN9 OEL-THE NETHERLANDS:TWA 40 ppm (70 mg/m3) OEL-THE PHILIPPINES:TWA 40 ppm (70 mg/m3) OEL-RUSSIA:STEL 10 mg/m3 OEL-SWITZERLAND:TWA 40 ppm (70 mg/m3);STEL 80 ppm ;Skin OEL-TURKEY:TWA 40 ppm (70 mg/m3) OEL-UNITED KINGDOM:TWA 40 ppm (70 mg/m3);STEL 60 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 4/23/1999 Revision #4 Date: 3/20/2001 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------