70012IBI/Shelton Scientific 230 Long Hill Cross Rd Shelton, CT 06484 Manufacturer's Name: IBI/Shelton Scientific 230 Long Hill Cross Rd. Shelton, CT 06484 Emergency Telephone: Telephone Number for Information (800) 451-8346 (800) 253-4942 or (203) 929-8999 Date Prepared: 2-24-00 Reviewed: Identification Product #: IB70010 Name: Acryliquid-40 CAS#: N/A Blend (40% Acrylamide Solution) Toxicity Hazards Hazardous components: Acrylamide CAS# 79-06-1 RTECS# AS3325000 N,N' -Methylenebis (Acrylamide) CAS# 110-26-9 RTECS# AS3678000 Acrylamide Irritation Data SKN-RBT 50 MG/3D MLD TXAPA9 6, 172, 64 SKN-RBT 500 MG/24H MLD 85JCAE - , 337, 86 EYE-RBT 10 MG/30S RINSE MLD TXAPA9 6, 172, 64 EYE-RBT 100 MG/24H MOD 28ZPAK - , 54, 72 Toxicity Data ORL-RAT LD50: 124 MG/KG AMPMAR 36, 58, 75 SKN-RAT LD50: 400 MG/KG GISAAA 44 (10), 73, 79 IPR-RAT LD50: 90 MG/KG AMPMAR 36, 58, 75 UNR-RAT LD50: 208 MG/KG GISAAA 43 (9), 38, 78 ORL-MUS LD50: 107 MG/KG ARTODN 47, 179, 81 IPR-MUS LD50: 170 MG/KG TXAPA9 33, 142, 75 UNR-MUS LD50: 156 MG/KG GISAAA 43 (9), 38, 78 ORL-RBT LD50: 150 MG/KG TXAPA9 6, 172, 64 UNR-RBT LD50: 280 MG/KG GISAAA 43 (9), 38, 78 SCU-GPG LD50: 170 MG/KG MELAAD 47, 192, 56 UNR-GPG LD50: 173 MG/KG GISAAA 43, (9), 38, 78 ORL-GPG LD50: 150 MG/KG TXAPAA 96, 72, 64 ORL-QAL LD50: 186 MG/KG JTEHD6 7, 935, 81 ORL-MAM LD50: 100 MG/KG KASEAA 17, 495, 79 Reviews, Standards and Regulations ACGIH TLV-Suspected Carcinogen 85INA8 5, 12, 86 ACGIH TLV-TWA 0.03 MG/M3 (skin) 85INA8 5, 12, 86 IARC Cancer Review: Animal Sufficient Evidence IMEMDT 39, 41, 86 IARC Cancer Review: Human No Adequate Data IMEMDT 39, 41, 86 IARC Cancer Review: Group 2B IMSUDL 7, 56, 87 MSHA Standard-Air: TWA 0.3 MG/M3 (skin) DTLVS* 3, 5, 71 OSHA PEL: 8H TWA 0.3 MG/M3 (skin) FEREAC 54, 2923, 89 OSHA PEL FINAL: 8H TWA 0.03 MG/M3 (skin) FEREAC 54, 2923, 89 OEL-AUSTRALIA: TWA 0.3 MG/M3; Skin; Carcinogen January 1993 OEL-BELGIUM: TWA 0.3 MG/M3; Skin; Carcinogen January 1993 OEL-DENMARK: TWA 0.3 MG/M3; Skin; Carcinogen January 1993 OEL-FINLAND: TWA 0.3 MG/M3; Stel 0.9 MG/M3 January 1993 OEL-FRANCE: TWA 0.3 MG/M3 January 1993 OEL-GERMANY; Skin; Carcinogen January 1993 OEL-HUNGARY: Stel 0.3 MG/M3; Skin; Carcinogen January 1993 OEL-JAPAN: TWA 0.3 MG/M3; Skin January 1993 OEL-RUSSIA: Stel 0.2 MG/M3; Skin January 1993 OEL-SWEDEN: TWA 0.3 MG/M3; Stel 0.9 MG/M3; Skin January 1993 OEL-SWITZERLAND: TWA 0.3 MG/M3; Skin; Carcinogen January 1993 OEL-THE NETHERLANDS: TWA 0.3 MG/M3 January 1993 OEL-THE PHILLIPPINES: TWA 0.3 MG/M3; Skin January 1993 OEL-UNITED KINGDOM: TWA 0.3 MG/M3; Stel 0.6 MG/M3; Skin January 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA, NEW ZEALAND, SINGAPORE, VIETNAM CHECK ACGIH TLV NIOSH REL to Acrylamide-Air: 10H CA TWA 0.03 MG/M3 (SK) NIOSH* DHHS #92-100, 92 NOHS 1974: HZD 03540; NIS 10; TNF 442; NOS 24; TNE 7047 NOES 1983: HZD 03540; NIS 19; TNF 453; NOS 22; TNE 10651; TFE 721 EPA Genetox Program 1988, Positive: Cytogenetics-Male Germ Cell EPA Genetox Program 1988, Negative: In Vivo Cytogenetics-Nonhuman Bone Marrow EPA Genetox Program 1988, Inconclusive: In Vivo Sce-Nonhuman EPA TSCA Chemical Inventory, June 1990 EPA TSCA 8 (A) Preliminary Assessment Information, Final Rule FEREAC 47, 26992, 82 EPA TSCA Section 8 (E) Status Report 8EHQ-0783-0488 EPA TSCA Section 8 (E) Status Report 8EHQ-0785-0560 On EPA Iris Database EPA TSCA Test Submission (TSCATS) Data Base, January 1993 NTP 7TH Annual Report on Carcinogens, 1992: Anticipated To Be Carcinogen. OSHA Analytical Method #21 Target Organ Data Peripheral Nerve and Sensation (Flaccid Paralysis without Anesthesia) Behavioral (Altered Sleep Time) Behavioral (Tremor) Behavioral (Convulsions or Effect on Seizure Threshold) Behavioral (Change in Motor Activity) Behavioral (Muscle Contraction or Spasticity) Lungs, Thorax, or Respiration (Tumors) Gastrointestinal (Nausea or Vomiting) Blood (Other Changes) Skin and Appendages (Tumors) Paternal Effects (Spermatogenesis) Paternal Effects (Testes, Epididymis, Sperm Duct) Effects on Fertility (Male Fertility Index) Effects on Fertility (Pre-Implantation Mortality) Effects on Fertility (Post-Implantation Mortality) Effects on Embryo or Fetus (Fetotoxicity) Effects on Embryo or Fetus (Fetal Death) Specific Developmental Abnormalities (Musculoskeletal System) Tumorigenic Effects (Testicular Tumors) Tumorigenic Effects (Uterine Tumors) Effects on Newborn (Growth Statistics) Effects on Newborn (Biochemical and Metabolic) Tumorigenic Effects (Carcinogenic by RTECS Criteria) Tumorigenic Effects (Neoplastic by RTECS Criteria) Biochemical Effects (Transaminases) Biochemical Effects (Peptidases) __________________________N,N' -Methylenebis(Acrylamide)_________________________ Toxicity Data ORL-RAT LD50: 390 MG/KG 37ASAA 1,306, 78 ORL-MUS LD50: 401 MG/KG ARTODN 47, 179, 81 Reviews, Standards, and Regulations NOHS 1974: HZD 83963; NIS 4; TNF 199; NOS 5; TNE 2098 NOES 1983: HZD 83963; NIS 2; TNF 10; NOS 3; TNE 66; TFE 35 EPA TSCA Chemical Inventory June 1990 EPA TSCA SECTION 8 (E) Status Report 8EHQ-0880-0357 EPA TSCA TEST Submission (TSCATS) Data Base, January 1993 Target Organ Data Paternal Effects (Spermatogenesis) Paternal Effects (Testes, Epididymis, Sperm Duct) Effects on Fertility (Pre-Implantation Mortality) Effects on Fertility (Post-Implantation Mortality) Only selected registry of toxic effects of chemical substances (RTECS) data is presented here. See actual entry in RTECS for complete information. Health Hazard Data ACUTE EFFECTS: Harmful if swallowed, inhaled, or absorbed through skin. May cause eye and skin irritation May cause nervous system disturbances CHRONIC EFFECTS: May alter genetic material. Overexposure may cause reproductive disorder (s) based on tests with laboratory animals. Carcinogen. FIRST AID: In case of contact, immediately flush eyes or skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately. Physical Data Boiling point: 125 C/25MM. Melting point: 83 C to 85 C Vapor density: 2.45 Vapor pressure: 1.6 MM @ 84.5 C .03MM @ 40 C Appearance and Odor: Liquid Fire and Explosion Hazard Data Extinguishing Media Carbon dioxide, Dry Chemical Powder Appropriate Foam. Special Firefighting Procedures Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Use water spray to cool fire-exposed containers. Unusual Fire and Explosions Hazards Container explosion may occur under fire conditions. Emits toxic fumes under fire conditions. Reactivity Data Incompatibilities Avoid contact with acid. Bases Oxidizing agents. Air and moisture sensitive. Store away from heat and direct sunlight. May polymerize on exposure to light. Hazardous Combustion or Decomposition Products Thermal decomposition may produce carbon monoxide, carbon dioxide, and nitrogen oxides. Spill or Leak Procedures Steps To Be Taken If Material Is Released Or Spilled Evacuate area. Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves. Dike spill site. Use inert material to absorb spill. Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. Waste Disposal Method Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local laws. Precautions to be taken in Handling and Storage Wear appropriate NIOSH/MSHA-approved respirator, chemical-resistant gloves, safety goggles, other protective clothing. Use only in a chemical fume hood. Safety shower and eye bath. Do not breathe mists or vapors. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure. Readily absorbed through skin. Wash thoroughly after handling. Neurological hazard. Keep tightly closed. Store in a cool dry place. May cause cancer. Toxic by inhalation, in contact with skin and if swallowed. May cause nervous system disturbances. Target organ(s): Nerves Male reproductive system Sensitive to light If you feel unwell, seek medical advice (show the label where possible). In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. After contact with skin, wash immediately with plenty of water. Take off immediately all contaminated clothing. Wear suitable protective clothing, gloves and eye/face protection. Label Precautionary Statement POISON SUSPECTED CARCINOGEN NEUROTOXIN This product is subject to Sara Section 313 reporting requirements. Judgements as to the suitability of information herein for purchaser's purpose are necessarily the purchaser's responsibility. Therefore, although reasonable care has been taken in the preparation of such information, Shelton Scientific extends no warranties, makes no representations and assumes no responsibility as to the accuracy or suitability of such information for application to purchaser's to purchaser's intended purposes or for consequences of its use.