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@ Beckma n 
Coulter® MATERIAL SAFETY DATA SHEET 
Section 1 Company and Product Identification 

Product Name Bilirubin Calibrator 

Part Number 465915 
Doc. ID 465915­75 AD 
Issued (year/month/day)
Revised (year/month/day) 2006/03/29 

Product Use For In Vitro Diagnostic Use. See product literature for details. 
Series Name SYNCHRON Systems 
Manufacturer Beckman Coulter, Inc.
4300 Harbor Blvd.
Fullerton, CA 92835­3100, U.S.A. 
Distributor and
Emergency Phone No.  
Refer to attached list, Document ID:472050, for local distributor and
emergency phone numbers. 

Section 2 Composition and Information on Ingredients 

HazardousIngredients: Meets Hazardous Criteria: 
Chemical Name CAS# %bywt. EU USOSHA WHMIS 
Ethylene Glycol 107­21­1 25 Xn;R 22 Yes Exempt 

See Section 15 Regulatory Information for additional information on hazard classifications. 

Section 3 Hazards Identification 
Emergency Overview 
Amber; Translucent; Liquid; Odorless
Nonflammable aqueous solution.
Skin, eye and respiratory tract irritant.
Harmful if swallowed.
Contains material of human origin. 

Physical Hazards No physical hazards were determined from a review of available literature. 

Potential Health
Effects Summary 
May cause irritation of respiratory tract, skin and eyes; central nervous system
depression; severe kidney damage and reproductive effects. 
This product contains material of human origin and should be considered as
potentially capable of transmitting infectious diseases. 
See Section 11 Toxicological Information for more detailed health information. 

Product Hazard
Classifications 
EU:
Xn;R22 
WHMIS:
Exempt 
US OSHA:
Hazardous 

Beckman CoulterSafety
Rating 
Flammability (Section V):0
Health (Section XI):2
Reactivity with Water (Section X):0
Contact (Section VIII): 2 

Code
0=none
1=slight
2=caution
3=severe 

2006 Beckman Coulter, Inc. 
Global MSDS – English

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Bilirubin Calibrator MSDS # 465915­75 AD Page2of6 

Section 4 First Aid Measures 

Inhalation If product is inhaled, move exposed individual to fresh air. If individual is not
breathing, begin artificial respiration immediately and obtain medical attention. 
Eye Contact If product is splashed in eyes, wash eyes under gently running water for 15 minutes
or longer, making sure that the eyelids are held open. Obtain medical attention. 
Skin Contact In case of skin contact, flush with copious amounts of water for at least 15 minutes.
Remove contaminated clothing and shoes. If pain or irritation occur, obtain medical
attention. 
Ingestion If ingested, wash mouth out with water. If irritation or discomfort occurs, seek medical
attention. 

Section 5 Fire Fighting Measures 

Flash Point Not applicable 
FlammableLimits Not applicable 
AutoignitionTemp. Not applicable 
Extinguishing Media Use extinguishing media suitable for surrounding fire. 

Special Fire and
Explosion Hazards 
No special hazards determined. 

Hazardous Combustion
Products 
No combustion products posing significant hazards are expected from this product (an
aqueous solution). 

Protective Equipment
for Firefighters 
Self­contained breathing apparatus is recommended for firefighters. 

Section 6 Accidental Release Measures 

Personal Precautions This product contains a material of biological origin. Use universal precautions during
clean up procedures. 
Spill and Leak
Procedures 
As a precautionary measure, treat spilled material with a 1:10 bleach/water solution.
Absorb liquid and place in container suitable for disposal. Avoid generation of
aerosols during clean up. Comply with applicable waste disposal regulations. 

Environmental
Precautions 
Contain spill to prevent migration. 

Section 7 Handling and Storage 

Handling Precautions This product should be handled as though capable of transmitting infectious diseases.
Universal precautions should be followed when using this product. 

Recommended Storage
Conditions 
Keep away from incompatible material (see Section 10).
To maintain efficacy, store according to the instructions in the product labeling. 

Section 8 Exposure Controls and Personal Protection 

Exposure Limits 

US OSHA: None established

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Bilirubin Calibrator MSDS # 465915­75 AD Page3of6 

Section 8 Exposure Controls and Personal Protection (Continued) 

ACGIH: 

Ethylene Glycol 100 mg/m3 Ceiling (aerosol only) 

DFG MAK: 
Ethylene Glycol 10 ppm MAK; 26 mg/m3 MAK; 20 ppm Peak; 52 mg/m3 Peak; skin notation 
Engineering Controls Use in well ventilated area. 

Respiratory Protection Under normal conditions, the use of this product should not require respiratory
protection. If overexposure should occur and ventilation is not adequate to maintain
airborne concentrations at acceptable levels, the use of respiratory protection should
be evaluated by a qualified professional. 
Eye Protection Safety glasses or chemical goggles should be worn to prevent eye contact. 

Skin Protection Impervious gloves, such as Nitrile or equivalent, should be worn to prevent skin
contact. 

Section 9 Physical and Chemical Properties 

Physical State Liquid 

Color Amber 
Transparency Translucent 
Odor Odorless 
Odor Threshold Not applicable 
pH 8.6 +/­ 0.2 

Boiling Point Not available 

Melting Point Not available 

Specific Gravity 1.059 @20°C 

Vapor Pressure Not available 

Vapor Density Not available 

Evaporation Rate Not available 

Solubility 
Water Miscible 
Organic Not available 

Section 10 Stability and Reactivity 

Stability Stable under normal temperatures and pressures. 
Hazardous
Incompatibilities 
Strong oxidizers
Strong acids
Strong bases 
Hazardous
Decomposition Products 
When stored as labeled, no known hazardous decomposition products are formed
during the shelf­life of this product. 
Conditions to Avoid Keep away from incompatible material.

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Bilirubin Calibrator MSDS # 465915­75 AD Page4of6 

Section 11 Toxicological Information 

Toxicity Data
for Hazardous Ingredients 
Ethylene Glycol Oral LD50 Rat: 4000 mg/kg; Dermal LD50 Rabbit: 9530 µL/kg 
Primary Routes
of Exposure 
Common routes of entry include inhalation, ingestion and eye/skin contact. Specific
paths of concern for potentially infectious materials are skin puncture, contact with
broken skin, contact with mucous membranes and inhalation of aerosolized material. 
Potential Effects of
Acute Exposure 
This product contains material of human origin and should be considered as
potentially capable of transmitting infectious diseases.
Exposure to ethylene glycol may result in eye and respiratory tract irritation.
Inhalation of mists and absorption through skin may cause central nervous system
depression. Ingestion may cause severe central nervous system depression, kidney
failure, heart failure or respiratory arrest. 
Potential Effects of
Chronic Exposure 
Prolonged or repeated exposure to ethylene glycol may result in mild irritation
and central nervous system depression; symptoms may include throat irritation,
drowsiness, headache and backache. Contact with skin and eyes may result in
dermatitis and conjunctivitis with red, scaly skin and inflamed eyes. Animal studies
indicate repeated ingestion of small amounts can cause severe kidney damage. 

Symptoms of
Overexposure 
Symptoms of overexposure may include: eye, skin, nose and throat irritation;
headache, weakness, dizziness, confusion, nausea and vomiting. Severe cases
may exhibit difficulty in breathing, irregular heartbeat, reddish colored skin,
unconsciousness, convulsions, coma and death. Symptoms may be delayed for
several hours after exposure. 

Carcinogenicity No ingredients in this product are listed as carcinogens by ACGIH, IARC, NTP, OSHA
or 67/548/EEC Annex I. 
Other Effects Reproductive effects have been reported in animal studies. 

Conditions Aggravated
by Exposure 
Individuals with eye and skin disorders may find these conditions aggravated by
exposure to this product.
Individuals with central nervous system, cardiovascular, or kidney disorders may find
these conditions aggravated by exposure to this product. 

Section 12 Ecological Information 

Ecotoxicity No information available. 

Biodegradability No information available. 

Mobility No information available. 

Section 13 Disposal Considerations 

Waste Disposal Dispose of waste product, unused product and contaminated packaging in compliance
with federal, state and local regulations. If unsure of the applicable requirements,
contact the authorities for information. 

Section 14 Transport Information 

Transportation of this product is not regulated under ICAO, IMDG, US DOT, European ADR or Canadian TDG.

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Bilirubin Calibrator MSDS # 465915­75 AD Page5of6 

Section 15 Regulatory Information 

US FederalandStateRegulations 

SARA 313 Acetaldehyde is subject to reporting requirements of Section 313, Title III of SARA.
Ethylene Oxide is subject to reporting requirements of Section 313, Title III of SARA.
Ethylene Glycol is subject to reporting requirements of Section 313, Title III of SARA.
1,4­Dioxane is subject to reporting requirements of Section 313, Title III of SARA.
Hydrochloric Acid is subject to reporting requirements of Section 313, Title III of SARA. 
CERCLA RG’s,
40 CFR 302.4 
Acetaldehyde is listed.
Ethylene Oxide is listed.
Ethylene Glycol is listed.
1,4­Dioxane is listed.
Sodium Hydroxide is listed.
Hydrochloric Acid is listed. 

California Proposition 65 Acetaldehyde has been identified by the State of California to cause cancer. The State
of California has adopted a regulation which requires a warning be given to individuals
who may be exposed to chemicals identified by the State to cause cancer or reproductive
harm. Accordingly, Beckman Coulter advises you of the following warning:
WARNING:This product contains a chemical known to the State of California to cause
cancer.
Ethylene Oxide has been identified by the State of California to cause cancer and
reproductive harm. The State of California has adopted a regulation which requires a
warning be given to individuals who may be exposed to chemicals identified by the State
to cause cancer or reproductive harm. Accordingly, Beckman Coulter advises you of the
following warning:
WARNING:This product contains a chemical known to the State of California to cause
cancer and reproductive harm.
1,4­Dioxane has been identified by the State of California to cause cancer. The State of
California has adopted a regulation which requires a warning be given to individuals who
may be exposed to chemicals identified by the State to cause cancer or reproductive
harm. Accordingly, Beckman Coulter advises you of the following warning:
WARNING:This product contains a chemical known to the State of California to cause
cancer. 
Massachusetts MSL Acetaldehyde is listed.
Ethylene Oxide is listed.
Ethylene Glycol is listed.
1,4­Dioxane is listed.
Sodium Hydroxide is listed.
Hydrochloric Acid is listed.
Magnesium Chloride, Hexahydrate is listed. 
New Jersey Dept. of
Health RTK List 
Acetaldehyde is listed.
Ethylene Oxide is listed.
Ethylene Glycol is listed.
1,4­Dioxane is listed.
Sodium Hydroxide is listed.
Hydrochloric Acid is listed.
Magnesium Chloride, Hexahydrate is listed. 
Pennsylvania RTK Acetaldehyde is listed.
Ethylene Oxide is listed.
Ethylene Glycol is listed.
1,4­Dioxane is listed.
Sodium Hydroxide is listed.
Hydrochloric Acid is listed.
Magnesium Chloride, Hexahydrate is listed.

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Section 15 Regulatory Information (Continued) 

EU Labeling Classification 
Classification Risk and Safety Phrases 
Xn 

Harmful 

R22 Harmful if swallowed. 

Canada 
This product is exempt from WHMIS label and MSDS requirements. 
PIN: Not applicable 

Ingredients on Ingredient
Disclosure List: 
Acetaldehyde
Ethylene Oxide
Ethylene Glycol
1,4­Dioxane
Sodium Hydroxide
Hydrochloric Acid 
Ingredients with unknown
toxicological properties: 
Product is exempt 

Section 16 Other Information 
For further information, please contact your local Beckman Coulter representative. 

WHILE BECKMAN COULTER, INC. BELIEVES THE INFORMATION CONTAINED HEREIN IS VALID AND ACCURATE, BECKMAN COULTER MAKES NO WARRANTY OR
REPRESENTATION AS TO ITS VALIDITY, ACCURACY, OR CURRENCY. BECKMAN COULTER SHALL NOT BE LIABLE OR OTHERWISE RESPONSIBLE IN ANY WAY FOR USE
OF EITHER THIS INFORMATION OR MATERIALS TO WHICH IT APPLIES. DISPOSAL OF HAZARDOUS MATERIALS MAY BE SUBJECT TO LOCAL LAWS OR REGULATIONS.
Printed in U.S.A.

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