Material Safety Data Sheet Carbamylcholine Chloride, 99.0-101.0% (on the Dried Substance) ACC# 87134 Section 1 - Chemical Product and Company Identification MSDS Name: Carbamylcholine Chloride, 99.0-101.0% (on the Dried Substance) Catalog Numbers: AC108240000, AC108240050, AC108240100, AC108240250, AC108241000, AC108240050 AC108240050 Synonyms: Carbachol; (2-Hydroxyethyl)trimethylammonium Chloride Carbamate. Company Identification: Acros Organics N.V. One Reagent Lane Fair Lawn, NJ 07410 For information in North America, call: 800-ACROS-01 For emergencies in the US, call CHEMTREC: 800-424-9300 Section 2 - Composition, Information on Ingredients CAS# Chemical Name Percent EINECS/ELINCS 51-83-2 CARBAMYLCHOLINE CHLORIDE 99% 200-127-3 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: white crystalline powder crystalline powder. Danger! May be fatal if swallowed. Causes eye, skin, and respiratory tract irritation. Hygroscopic (absorbs moisture from the air). Target Organs: Respiratory system, eyes, skin. Potential Health Effects Eye: Causes eye irritation. May cause chemical conjunctivitis. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May be fatal if swallowed. Poison by ingestion. May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Ingestion may cause colic, constipation and weakness. Ingestion of large amounts may cause leg cramps and muscle weakness. Inhalation: Causes respiratory tract irritation. Harmful if inhaled. Chronic: No information found. Section 4 - First Aid Measures Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid immediately. Call a poison control center. If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: Treat symptomatically and supportively. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Dangerous fire hazard in the form of dust when exposed to heat or flame. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Flash Point: Not applicable. Autoignition Temperature: Not applicable. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 3; Flammability: 1; Instability: 1 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Minimize dust generation and accumulation. Do not breathe dust, mist, or vapor. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Avoid ingestion and inhalation. Do not ingest or inhale. Use only in a chemical fume hood. Wash clothing before reuse. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs CARBAMYLCHOLINE CHLORIDE none listed none listed none listed OSHA Vacated PELs: CARBAMYLCHOLINE CHLORIDE: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - Physical and Chemical Properties Physical State: Crystalline powder Appearance: faint yellow - white crystalline powder Odor: odorless pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point:200-204 deg C Decomposition Temperature:> 210 deg C Solubility: practically insoluble in chloroform and Specific Gravity/Density:Not available. Molecular Formula:C6H15ClN2O2 Molecular Weight:182.65 Section 10 - Stability and Reactivity Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Hygroscopic: absorbs moisture or water from the air. Conditions to Avoid: Incompatible materials, dust generation, excess heat, exposure to moist air or water. Incompatibilities with Other Materials: Strong oxidizing agents, strong acids. Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. Hazardous Polymerization: Has not been reported. Section 11 - Toxicological Information RTECS#: CAS# 51-83-2: GA0875000 LD50/LC50: CAS# 51-83-2: Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg; . Carcinogenicity: CAS# 51-83-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: No information found Teratogenicity: No information found Reproductive Effects: No information found Mutagenicity: No information found Neurotoxicity: No information found Other Studies: Section 12 - Ecological Information No information available. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: None listed. Section 14 - Transport Information US DOT Canada TDG Shipping Name: DOT regulated - small quantity provisions apply (see 49CFR173.4) TOXIC SOLID, ORGANIC, N.O.S. Hazard Class: 6.1 UN Number: UN2811 Packing Group: II Section 15 - Regulatory Information US FEDERAL TSCA CAS# 51-83-2 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs None of the chemicals in this material have an RQ. SARA Section 302 Extremely Hazardous Substances CAS# 51-83-2: 500 lb lower threshold TPQ; 10000 lb upper threshold TPQ Section 313 No chemicals are reportable under Section 313. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 51-83-2 can be found on the following state right to know lists: New Jersey, Pennsylvania, Massachusetts. California Prop 65 California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T Risk Phrases: R 25 Toxic if swallowed. R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 Wear suitable protective clothing, gloves and eye/face pr otection. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S 28A After contact with skin, wash immediately with plenty of water . WGK (Water Danger/Protection) CAS# 51-83-2: No information available. Canada - DSL/NDSL CAS# 51-83-2 is listed on Canada's NDSL List. Canada - WHMIS This product has a WHMIS classification of D1A. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List Section 16 - Additional Information MSDS Creation Date: 5/11/1999 Revision #5 Date: 9/26/2007 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.