E R SQUIBB MEDATOPE DIV -- 0015-3214-30 PARAPLATIN (CARBOPLATIN FOR INJE ======================================================= MSDS Safety Information ======================================================= FSC: 6505 NIIN: 01-308-2300 MSDS Date: 01/07/1993 MSDS Num: CDFVD Product ID: 0015-3214-30 PARAPLATIN (CARBOPLATIN FOR INJECTION) 150 MG MFN: 01 Responsible Party Cage: GO533 Name: E R SQUIBB MEDATOPE DIV Address: 5 GORDIS RD BLDG 124 Box: 191 City: NEW BRUNSWICK NJ 08903-5000 Info Phone Number: 800-332-2056/908-519-3843 Emergency Phone Number: 908-519-3843/609-921-4081 Review Ind: Y Published: Y ======================================================= Preparer Co. when other than Responsible Party Co. ======================================================= Cage: GO533 Assigned Ind: Y Name: E R SQUIBB MEDATOPE DIV Address: 5 GORDIS RD BLDG 124 Box: 191 City: NEW BRUNSWICK NJ 08903-5000 ======================================================= Contractor Summary ======================================================= Cage: 4T649 Name: E R SQUIBB MEDATOPE DIV Address: 5 GORDIS RD BLDG 124 Box: 191 City: NEW BRUNSWICK NJ 08903 Phone: 609-921-4081 Cage: GO533 Name: E R SQUIBB MEDATOPE DIV Address: 5 GORDIS RD BLDG 124 Box: 191 City: NEW BRUNSWICK NJ 08903-5000 Phone: 800-332-2056/908-519-3843 ======================================================= Item Description Information ======================================================= Item Manager: S9M Item Name: CARBOPLATIN FOR INJECTION Unit of Issue: VI Quantitative Expression: 00000000150MG UI Container Qty: 1 ======================================================= Ingredients ======================================================= Cas: 41575-94-4 RTECS #: TP2300000 Name: PLATINUM, DIAMMINE [1,1-CYCLOBUTANE-DICARBOXYLATO (2-)-O,0'] % Wt: 50 ------------------------------ Cas: 69-65-8 RTECS #: OP2060000 Name: MINNITOL, D- (MANNA SUGAR); MANNITOL % Wt: >1 ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: ORAL LD50(RAT): 343 MG/KG Route Of Entry Inds - Inhalation: YES Skin: NO Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: CARBOPLATIN IS TOXIC AFTER ACUTE INGESTION. INHALATION: TRANSIENT BRONCHIAL IRRITATION MAY OCCUR. EYES: MATERIAL MAY CAUSE CONJUNCTIVITIS. AFTER SYSTEMIC INJECTION, MAY CAUSE ANAPHYLACTOID REACTIONS. SIDE EFFECT MAY INCLUDE: REVERSIBLE BLOOD EFFECTS, HEPATIC TOXICITY, KIDNEY ABNORMALITIES & ELECTROLYTE LOSS. Explanation Of Carcinogenicity: NONE Signs And Symptions Of Overexposure: IRRITATION, RASH, NAUSEA, VOMITING, WHEEZING, RESPIRATORY DIFFICULTY, HYPOTENSION, RINGING OF THE EARS, HEARING LOSS Medical Cond Aggravated By Exposure: KIDNEY DISEASE, HEARING DISORDERS, NEUROLOGICAL DISEASES, ANEMIA/OTHER FORMS OF BONE MARROW SUPPRESSION. First Aid: INGESTION: INDUCTION OF VOMITING, IF PERSON IS CONSCIOUS & NOT EXPERIENCING CONVULSIONS. NEVER GIVE ANYTHING BY MOUTH IF UNCONSCIOUS. INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NECESSARY. SKI N: IMMEDIATELY FLUSH W/LARGE AMOUNTS OFWATER. USE SOAP IF AVAILABLE. EYES: FLUSH W/RUNNING WATER FOR 15 MINS. OBTAIN MEDICAL ATTENTION IN ALL CASES. PRODUCT CONTAINS A CYTOTOXIC ANTINEOPLASTIC DRUG. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: SMALL: WIPE LIQUIDS W/ABSORBENT GAUZE PADS. CLEAN W/DETERGENT & WATER. COVER POWDER W/GAUZE PAD/PAPER TOWEL. SOAK W/WATER, WIPE UP W/DETERGENT & WATER. LARGE: COVER LIQUID W/ABSORBENT SHEETS/CONTROL P ADS/PILLOWS. COVER W/DAMP CLOTH/TOWELS.(SEE SUPP) Waste Disposal Methods: TREAT PRODUCTS & CONTAMINATED MATERIALS AS A HAZARDOUS MATERIAL. INCINERATION AT AN APPROVED FACILITY IS RECOMMENDED. DISPOSE OF IAW/LOCAL, STATE & FEDERAL REGULATIONS. Handling And Storage Precautions: STORE AT ROOM TEMP 59F-77F. DON'T REFRIGERATE. PROTECT FROM LIGHT. DON'T BREAK VIALS/SPILL CONTENTS. DON'T ALLOW PARAPLATIN TO CONTACT ALUMINUM. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: FLOOD W/WATER Fire Fighting Procedures: WEAR SCBA, FLAME & CHEMICAL RESISTANT CLOTHING, BOOTS, GLOVES. EVACUATE PERSONNEL TO UPWIND DIRECTION. COOL CONTAINERS W/WATER FROM A MAXIMUM DISTANCE. Unusual Fire/Explosion Hazard: FINE POWDERS ARE CONSIDERED TO BE COMBUSTIBLE. ======================================================= Control Measures ======================================================= Respiratory Protection: WHEN ENGINEERING CONTROLS AREN'T SUFFICIENT TO CONTROL EXPOSURE, WEAR APPROVED DUST RESPIRATOR W/HIGH EFFICIENCY DUST FILTER/POWDERED AIR-PURIFYING RESPIRATOR; SELF CONTAINED BREATHING APPARATUS. Ventilation: LOCAL MECHANICAL EXHAUST VENTILATION TO MINIMIZE EMPLOYEE EXPOSURE. Protective Gloves: DISPOSABLE SURGICAL LATEX Eye Protection: CHEMICAL SAFETY GOGGLES (ANZI Z87.1) Other Protective Equipment: IMPERVIOUS DISPOSABLE OVERALLS W/CLOSED FRONT, LONG SLEEVES, ELASTIC CUFFS, BOOTS. Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES BEFORE REUSE. Supplemental Safety and Health: PH: 5-7 (1% SOLUTION). SPILL PROC CONT'D: LARGE: CLEAN USING DETERGENTS & WATER. GLOVES SHOULD BE CHANGED REGULARLY & REMOVED IMMEDIATELY AFTER OVERT CONTAMINATION. DOUBLE GLOVING IS RECOMMENDED. WASH HANDS, FOREARMS & FACE THOROUGHLY AFTER HANDLING & BEFORE EATING, SMOKING, USING LAVATORY & AT THE END OF DAY. ======================================================= Physical/Chemical Properties ======================================================= M.P/F.P Text: >446F PH: (SUPP) Solubility in Water: 14 MG/ML Appearance and Odor: WHITE LYOPHILIZED POWDER WHICH IS PACKAGED IN VIALS. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Stability Condition To Avoid: LIGHT Materials To Avoid: FORMATION OF A PLATINUM PRECIPITATE WHEN PARAPLATIN COMES IN CONTACT W/ALUMINUM. Hazardous Decomposition Products: CO, CARBON OXIDES, NITROGEN OXIDES Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= ======================================================= Ecological Information ======================================================= ======================================================= MSDS Transport Information ======================================================= ======================================================= Regulatory Information ======================================================= ======================================================= Other Information ======================================================= ======================================================= HAZCOM Label ======================================================= Product ID: 0015-3214-30 PARAPLATIN (CARBOPLATIN FOR INJECTION) 150 MG Cage: GO533 Assigned IND: Y Company Name: E R SQUIBB MEDATOPE DIV Street: 5 GORDIS RD BLDG 124 PO Box: 191 City: NEW BRUNSWICK NJ Zipcode: 08903-5000 Health Emergency Phone: 908-519-3843/609-921-4081 Label Required IND: Y Date Of Label Review: 10/12/1999 Status Code: A Origination Code: G Hazard And Precautions: CARBOPLATIN IS TOXIC AFTER ACUTE INGESTION. INHALATION: TRANSIENT BRONCHIAL IRRITATION MAY OCCUR. EYES: MATERIAL MAY CAUSE CONJUNCTIVITIS. AFTER SYSTEMIC INJECTION, MAY CAUSE ANAPHYLACTOID REACTIONS. SIDE EFFECT MAY INCLUDE: REVERSIBLE BLOOD EFFECTS, HEPATIC TOXICITY, KIDNEY ABNORMALITIES & ELECTROLYTE LOSS. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.