SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 08/OCT/2003 
Date Updated: 09/APR/2002 
Version 1.0 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name D-TUBOCURARINE CHLORIDE 
Product Number T2379 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
(+)-TUBOCURARINE CHLORIDE 57-94-3 200-356-9 
PENTAHYDRATE* 
Formula C37H42Cl2N2O6 
Molecular Weight 681.7 AMU 
Synonyms Amerizol,Curarin-haf,Delacurarine, 
Dextrotubocurarine chloride,d-7',12'-Dihydroxy-6, 
6'-dimethoxy-2,2', 
2'-trimethyltubocuraranium chloride,Intocostrin, 
Intocostrine T,d-Paracurarine chloride,Tubadil, 
Tubarine,Tubocurarine chloride,Tubocurarine, 
chloride, hydrochloride, (+)- (8CI), 
d-Tubocurarine chloride, 
d-Tubocurarine dichloride, 
Tubocurarine hydrochloride, 
d-Tubocurarine hydrochloride 
3 - Hazards Identification 
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT 
Toxic if swallowed. 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If not breathing give 
artificial respiration. If breathing is difficult, give oxygen. 
AFTER SKIN CONTACT 
In case of skin contact, flush with copious amounts of water for 
at least 15 minutes. Remove contaminated clothing and shoes. 
Call a physician. 
AFTER EYE CONTACT 
In case of contact with eyes, flush with copious amounts of 
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician immediately. 
5 - Fire Fighting Measures 
EXTINGUISHING MEDIA 
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam. 
SPECIAL RISKS 
Specific Hazard(s): Emits toxic fumes under fire conditions. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL 
Evacuate area. 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear self-contained breathing apparatus, rubber boots, and heavy 
rubber gloves. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Do not breathe dust. Do not get in 
eyes, on skin, on clothing. Avoid prolonged or repeated exposure. 
STORAGE 
Conditions of Storage: Keep tightly closed. 
Store at 2-8°C 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Safety shower and eye bath. Use only in a chemical fume hood. 
GENERAL HYGIENE MEASURES 
Wash contaminated clothing before reuse. Wash thoroughly after 
handling. 
PERSONAL PROTECTIVE EQUIPMENT 
Respiratory Protection: Government approved respirator. 
Hand Protection: Compatible chemical-resistant gloves. 
Eye Protection: Chemical safety goggles. 
9 - Physical and Chemical Properties 
Appearance Physical State: Solid 
Color: White 
Form: Powder 
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Property Value At Temperature or Pressure 
pH N/A 
BP/BP Range N/A 
MP/MP Range 275 °C 
Flash Point N/A 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
Partition Coefficient N/A 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. N/A 
Solvent Content N/A 
Water Content 12 % 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility N/A 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Materials to Avoid: Strong oxidizing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, 
Nitrogen oxides, Hydrogen chloride gas. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: YO4900000 
ACUTE TOXICITY 
LD50 
Oral 
Rat 
28 mg/kg 
LD50 
Intraperitoneal 
Rat 
340 UG/KG 
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or 
Respiration:Respiratory depression. Lungs, Thorax, or 
Respiration:Other changes. 
LD50 
Subcutaneous 
Rat 
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310 UG/KG 
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or 
Respiration:Respiratory depression. Lungs, Thorax, or 
Respiration:Other changes. 
LD50 
Intravenous 
Rat 
66 UG/KG 
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or 
Respiration:Respiratory depression. Lungs, Thorax, or 
Respiration:Other changes. 
LD50 
Oral 
Mouse 
33 mg/kg 
LD50 
Intraperitoneal 
Mouse 
420 UG/KG 
LD50 
Subcutaneous 
Mouse 
640 UG/KG 
Remarks: Behavioral:Muscle weakness. Lungs, Thorax, or 
Respiration:Respiratory depression. Lungs, Thorax, or 
Respiration:Other changes. 
LD50 
Intravenous 
Mouse 
97 UG/KG 
LD50 
Intramuscular 
Mouse 
540 UG/KG 
LD50 
Intravenous 
Rabbit 
170 UG/KG 
LD50 
Intravenous 
Guinea pig 
66 UG/KG 
Remarks: Behavioral:Convulsions or effect on seizure threshold. 
Lungs, Thorax, or Respiration:Other changes. 
SIGNS AND SYMPTOMS OF EXPOSURE 
To the best of our knowledge, the chemical, physical, and 
toxicological properties have not been thoroughly investigated. 
ROUTE OF EXPOSURE 
Skin Contact: May cause skin irritation. May be toxic in contact 
with skin. 
Eye Contact: May cause eye irritation. 
Inhalation: May be toxic by inhalation. Material may be 
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irritating to mucous membranes and upper respiratory tract. 
Ingestion: Toxic if swallowed. 
TARGET ORGAN INFORMATION 
Nerves. Skeletal muscle. 
CHRONIC EXPOSURE - MUTAGEN 
ZINCL 
Histidine reversion (Ames) 
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Contact a licensed professional waste disposal service to dispose 
of this material. Dissolve or mix the material with a combustible 
solvent and burn in a chemical incinerator equipped with an 
afterburner and scrubber. Observe all federal, state, and local 
environmental regulations. 
14 - Transport Information 
RID/ADR 
UN#: 1544 
Class: 6.1 
PG: II 
Proper Shipping Name: Alkaloid salts, solid, n.o.s. 
IMDG 
UN#: 1544 
Class: 6.1 
PG: II 
EmS Number: 6.1-04 
MFAG Number: 805 
Proper Shipping Name: ALKALOID SALTS, SOLID, N.O.S. 
Marine Pollutant: No 
Severe Marine Pollutant: No 
Technical Name: X 
IATA 
UN#: 1544 
Class: 6.1 
PG: II 
Proper Shipping Name: Alkaloid salts, solid, n.o.s. 
Inhalation Packing Group I: No 
Technical Name: X 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
INDICATION OF DANGER: T 
Toxic. 
R-PHRASES: 25 
Toxic if swallowed. 
S-PHRASES: 45 
In case of accident or if you feel unwell, seek medical advice 
immediately (show the label where possible). 
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16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
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