Size D609, Potassium Salt 
5 mg Cat. No. 251400 
Tricyclodecan-9-yl-xanthate, Potassium Salt Synonym: 
Description: Selective inhibitor of phosphatidylcholine-specific phospholipase C (PCPLC) 
( Bacillus cereus, Ki = 5-10 mM). Does not inhibit (up to 50 mM) 
phosphatidylinositol-specific phospholipase C, phospholipase A2, and 
phospholipase D. Inhibitor of the sphingomyelinase activity. Also 
inhibits angiogenesis by preventing the synthesis of basement 
membrane (BM). 
Off-white solid Form: 
83373-60-8 CAS Number: 
266.5 Molecular Weight: 
Molecular Formula: C11H15OS2 × K 
Structure: 
S 
O KS 
Purity: ³97% by TLC 
Solubility: H2O (25 mg/ml) and DMSO (25 mg/ml). Note: tissue culture media 
should be at neutral pH, since product is active only at or slightly below 
pH 7.0. The compound is inactive at pH 7.4 and above, and it is 
hydrolyzed below pH 6.0. HEPES buffer should not be used as it 
renders D609 toxic. 
Storage: Refrigerate (+4°C). This product is stable for 2 years as supplied. 
Material is very labile once in solution (1.5 day half-life in tissue culture 
medium). 
References: Sortino, M.A., et al. 1999. Endocrinology 140, 4841. 
Lozanski, G., et al. 1997. Biochem. J. 328, 271. 
United Kingdom USA & Canada Germany 
Tel 0115 9430 840 Tel (800) 628-8470 Tel 0800 6931 000 
E-mail address for technical inquiries: technical@calbiochem.com 
Find our current product data sheets on the web: http://www.calbiochem.com 
Revised: 05-January-00
CN: 251400 
Maragoudakis, M.E., et al. 1993. Kidney Int. 43, 147. 
Doppler, C., et al. 1992. AIDS Res. Human Retroviruses 8, 245. 
Schutze, S., et al. 1992. Cell 71, 765. 
Sauer, G., et al. 1990. Cancer Lett. 53, 97. 
Muller-Decker, K. 1989. Biochem. Biophys. Res. Commun. 162, 198. 
Amtmann, E., et al. 1987. Biochem. Pharmacol. 36, 1545. 
Sauer, G., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 3263. 
Sold under license of U.S. Patent 4,602,037 issued to Merz and Co. 
GmbH. 
FOR RESEARCH USE ONLY. NOT FOR HUMAN OR DRUG USE.