UNITED STATES PHARMACOPEIAL CONVENTION -- DEFEROXAMINE MESYLATEUNITED STATES PHARMACOPEIAL CONVENTION -- DEFEROXAMINE MESYLATE 
MATERIAL SAFETY DATA SHEET
UNITED STATES PHARMACOPEIAL CONVENTIONNSN: 650500F036925
Manufacturer's CAGE: 14128 
Part No. Indicator: A 
Part Number/Trade Name: DEFEROXAMINE MESYLATE 
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                            General Information
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Company's Name: UNITED STATES PHARMACOPEIAL CONVENTION INC 
Company's Street: 12601 TWINBROOK PKWY 
Company's City: ROCKVILLE 
Company's State: MD 
Company's Country: US 
Company's Zip Code: 20852-1717 
Company's Emerg Ph #: 301-881-0666 
Company's Info Ph #: 301-881-0666 
Record No. For Safety Entry: 001 
Tot Safety Entries This Stk#: 001 
Status: SE 
Date MSDS Prepared: 13APR89 
Safety Data Review Date: 12OCT94 
MSDS Preparer's Name: WILLIAM M HELLER 
Preparer's Company: UNITED STATES PHARMACOPEIAL CONVENTION I 
Preparer's St Or P. O. Box: 12601 TWINBROOK PKWY 
Preparer's City: ROCKVILLE 
Preparer's State: MD 
Preparer's Zip Code: 20852-1717 
MSDS Serial Number: BVSRF 
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                     Ingredients/Identity Information
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Proprietary: NO 
Ingredient: DEFEROXAMINE MESYLATE *94-3*
Ingredient Sequence Number: 01 
Percent: 100 
NIOSH (RTECS) Number: UG5310000 
CAS Number: 138-14-7 
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                     Physical/Chemical Characteristics
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Appearance And Odor: WHITE TO OFF-WHITE CRYSTALLINE POWDER W/NO ODOR
Solubility In Water: COMPLETE 
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                      Fire and Explosion Hazard Data
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Extinguishing Media: WATER SPRAY, DRY CHEMICAL, CO2, FOAM AS APPROPRIATE
FOR SURROUNDING FIRE/MATERIALS.
Special Fire Fighting Proc: EVACUATE AREA. WEAR SELF CONTAINED BREATHING
APPARATUS & PROTECTIVE CLOTHING.
Unusual Fire And Expl Hazrds: MATERIAL IS ASSUMED TO BE COMBUSTIBLE. AS W/
ALL DRY POWDERS IT'S ADVISABLE TO GROUND MECHANICAL EQUIPMENT IN CONTACT W/
DRY MATERIAL TO DISSIPATE STATIC.
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                              Reactivity Data
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Stability: YES 
Materials To Avoid: OXIDIZING AGENTS
Hazardous Decomp Products: TOXIC FUMES, NITROGEN OXIDES
Hazardous Poly Occur: NO 
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                            Health Hazard Data
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LD50-LC50 Mixture: ORAL LD50 (RAT): 17300 MG/KG 
Route Of Entry - Inhalation: YES 
Route Of Entry - Skin: YES 
Route Of Entry - Ingestion: YES 
Health Haz Acute And Chronic: TACHYCARDIA. POSSIBLE ALLERGIC REACTION TO
DUST IF INHALED/INGESTED/CONTACT W/SKIN. EYE/SKIN/RESPIRATORY TRACT
IRRITATION. POSSIBLE HYPERSENSITIZATION. IRRITATING TO MUCOUS MEMBRANES &
RESPIRATORY TRACT. DEFEROXAMINE IS NOT RECOMMENDED FOR WOMEN OF CHILD-
BEARING POTENTIAL/DURING EARLY PREGNANCY. (SEE SUPP)
Carcinogenicity - NTP: NO 
Carcinogenicity - IARC: NO 
Carcinogenicity - OSHA: NO 
Explanation Carcinogenicity: NONE
Signs/Symptoms Of Overexp: LOCALIZED IRRITATION, SWELLING, FLUSHING OF
SKIN, HYPOTENSION, BLURRING OF VISION, PAINFUL URINATION, RAPID HEART RATE,
ABDOMINAL DISCOMFORT, DIARRHEA, FEVER, ITCHING, SKIN RASH, LEG CRAMPS.
Med Cond Aggravated By Exp: HYPERSENSITIVITY TO MATERIAL, RENAL
INSUFFICIENCY
Emergency/First Aid Proc: INHALATION: REMOVE TO FRESH AIR. GIVE CPR/
FLUSH MOUT OUT W/WATER. OBTAIN MEDICAL ATTENTION IN ALL CASES.
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                   Precautions for Safe Handling and Use
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Steps If Matl Released/Spill: WEAR APPROVED RESPIRATOR & CHEMICALLY
COMPATIBLE GLOVES. VACUUM/SWEEP UP. AVOID DUST. PLACE MATERIAL IN
APPROPRIATE CONTAINER FOR WASTE DISPOSAL. VENTILATE AREA & WASH SITE.
Waste Disposal Method: DISPOSE OF IAW/FEDERAL, STATE & LOCAL REGULATIONS.
Precautions-Handling/Storing: STORE IN TIGHT CONTAINER. SHOULD BE HANDLED/
STORED PER LABEL/OTHER INSTRUCTIONS TO ENSURE PRODUCT INTEGRITY. USE W/
ADEQUATE VENTILATION.
Other Precautions: AVOID CONTACT W/EYES, SKIN/CLOTHING. AVOID BREATHING
DUST/MIST/FUMES/VAPORS. USE W/ADEAUATE DUST CONROL. DON'T PERMIT EATING/
DRINKING/SMOKING NEAR MATERIAL.
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                             Control Measures
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Respiratory Protection: WEAR NIOSH APPROVED RESPIRATOR.
Ventilation: ADEQUATE. LOCAL EXHAUST/MECHANICAL (GENERAL): RECOMMENDED.
Protective Gloves: RUBBER 
Eye Protection: SAFETY GOGGLES 
Other Protective Equipment: APPROPRIATE LABORATORY APPAREL
Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Suppl. Safety & Health Data: INDIVIDUALS WORKING W/CHEMICALS SHOULD
CONSIDER ALL CHEMICALS TO BE POTENTIALLY HAZARDOUS EVEN IF THEIR INDIVIDUAL
HAZARDS MAY BE UNCHARACTERIZED/UNKNOWN. HEALTH HAZARDS CONT'D: IN CASES OF
MODERATE-SEVERE ACUTE IRON INTOXICATION, DEFEROXAMINE SHOULD BE USED SINCE
IRON IS ALSO TOXIC TO THE FETUS.
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                            Transportation Data
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                               Disposal Data
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                                Label Data
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Label Required: YES 
Label Status: G 
Common Name: DEFEROXAMINE MESYLATE 
Special Hazard Precautions: TACHYCARDIA. POSSIBLE ALLERGIC REACTION TO
DUST IF INHALED/INGESTED/CONTACT W/SKIN. EYE/SKIN/RESPIRATORY TRACT
IRRITATION. POSSIBLE HYPERSENSITIZATION. IRRITATING TO MUCOUS MEMBRANES &
RESPIRATORY TRACT. DEFEROXAMINE IS NOT RECOMMENDED FOR WOMEN OF CHILD-
BEARING POTENTIAL/DURING EARLY PREGNANCY. (SEE SUPP) LOCALIZED IRRITATION,
SWELLING, FLUSHING OF SKIN, HYPOTENSION, BLURRING OF VISION, PAINFUL
URINATION, RAPID HEART RATE, ABDOMINAL DISCOMFORT, DIARRHEA, FEVER,
ITCHING, SKIN RASH, LEG CRAMPS.
Label Name: UNITED STATES PHARMACOPEIAL CONVENTION INC 
Label Street: 12601 TWINBROOK PKWY 
Label City: ROCKVILLE 
Label State: MD 
Label Zip Code: 20852-1717 
Label Country: US 
Label Emergency Number: 301-881-0666