SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 08/OCT/2003 
Date Updated: 15/APR/2002 
Version 1.0 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name DICLOFENAC SODIUM SALT 
Product Number D174 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
DICLOFENAC SODIUM 15307-79-6 239-346-4 
Formula C14H10Cl2NNaO2 
Molecular Weight 318.1 AMU 
Synonyms Benzeneacetic acid, 2-((2, 
6-dichlorophenyl)amino)-, monosodium salt,(o-(2, 
6-Dichloroanilino)phenyl)acetic acid monosodium s 
alt,(o-(2, 
6-Dichloroanilino)phenyl)acetic acid sodium salt, 
2-((2, 
6-Dichlorophenyl)amino)benzeneacetic acid monosod 
ium salt,Dichronic,Diclofenac sodium, 
Diclophenac sodium,GP 45840,Huma-Difenac,Kriplex, 
Neriodin,Orthophen,Ortofen,Prophenatin, 
Sodium (o-(2,6-dichloroanilino)phenyl)acetate, 
Sodium (o-((2, 
6-dichlorophenyl)amino)phenyl)acetate, 
Sodium diclofenac,Tsudohmin,Valetan,Voltaren, 
Voltarol 
3 - Hazards Identification 
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT 
Toxic if swallowed. 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If not breathing give 
artificial respiration. If breathing is difficult, give oxygen. 
AFTER SKIN CONTACT 
In case of skin contact, flush with copious amounts of water for 
at least 15 minutes. Remove contaminated clothing and shoes. 
Call a physician.
AFTER EYE CONTACT 
In case of contact with eyes, flush with copious amounts of 
water for at least 15 minutes. Assure adequate flushing by 
separating the eyelids with fingers. Call a physician. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician immediately. 
5 - Fire Fighting Measures 
EXTINGUISHING MEDIA 
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam. 
SPECIAL RISKS 
Specific Hazard(s): Emits toxic fumes under fire conditions. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL 
Evacuate area. 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear self-contained breathing apparatus, rubber boots, and heavy 
rubber gloves. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Do not breathe dust. Do not get in 
eyes, on skin, on clothing. Avoid prolonged or repeated exposure. 
STORAGE 
Conditions of Storage: Keep tightly closed. 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Use only in a chemical fume hood. Safety shower and eye bath. 
GENERAL HYGIENE MEASURES 
Wash contaminated clothing before reuse. Wash thoroughly after 
handling. 
PERSONAL PROTECTIVE EQUIPMENT 
Respiratory Protection: Government approved respirator. 
Hand Protection: Compatible chemical-resistant gloves. 
Eye Protection: Chemical safety goggles. 
9 - Physical and Chemical Properties 
Appearance Physical State: Solid 
SIGMA - D174 www.sigma-aldrich.com Page 2
Color: White 
Property Value At Temperature or Pressure 
pH N/A 
BP/BP Range N/A 
MP/MP Range 275 - 277 °C 
Flash Point N/A 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
Partition Coefficient N/A 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. N/A 
Solvent Content N/A 
Water Content N/A 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility N/A 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Materials to Avoid: Strong oxidizing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, 
Nitrogen oxides, Hydrogen chloride gas. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: AG6330000 
ACUTE TOXICITY 
LD50 
Oral 
Rat 
53 mg/kg 
Remarks: Behavioral:Altered sleep time (including change in 
righting reflex). Behavioral:Ataxia. Lungs, Thorax, or 
Respiration:Respiratory stimulation. 
LD50 
Intraperitoneal 
Rat 
25 MG/KG 
LD50 
Subcutaneous 
SIGMA - D174 www.sigma-aldrich.com Page 3
Rat 
83 MG/KG 
LD50 
Intravenous 
Rat 
117 MG/KG 
LD50 
Rectal 
Rat 
85400 UG/KG 
LD50 
Oral 
Mouse 
95 mg/kg 
LD50 
Intraperitoneal 
Mouse 
74 MG/KG 
LD50 
Subcutaneous 
Mouse 
390 MG/KG 
LD50 
Intravenous 
Mouse 
116 MG/KG 
LD50 
Oral 
Dog 
59 mg/kg 
LD50 
Intravenous 
Dog 
42 MG/KG 
LD50 
Oral 
Rabbit 
157 mg/kg 
LD50 
Intravenous 
Rabbit 
>100 MG/KG 
SIGNS AND SYMPTOMS OF EXPOSURE 
Exposure can cause: Gastrointestinal disturbances. Nausea, 
dizziness, and headache. To the best of our knowledge, the 
chemical, physical, and toxicological properties have not been 
thoroughly investigated. 
ROUTE OF EXPOSURE 
Skin Contact: May cause skin irritation. 
Skin Absorption: May be harmful if absorbed through the skin. 
SIGMA - D174 www.sigma-aldrich.com Page 4
Eye Contact: May cause eye irritation. 
Inhalation: Material may be irritating to mucous membranes and 
upper respiratory tract. May be harmful if inhaled. 
Ingestion: Toxic if swallowed. 
TARGET ORGAN INFORMATION 
Kidneys. Liver. G.I. System. 
CHRONIC EXPOSURE - TERATOGEN 
Species: Rat 
Dose: 1 MG/KG 
Route of Application: Oral 
Exposure Time: (21D PREG) 
Result: Specific Developmental Abnormalities: Cardiovascular 
(circulatory) system. 
Species: Rat 
Dose: 6 MG/KG 
Route of Application: Oral 
Exposure Time: (9-14D PREG) 
Result: Effects on Embryo or Fetus: Fetotoxicity (except death, 
e.g., stunted fetus). 
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD 
Result: Overexposure may cause reproductive disorder(s) based on 
tests with laboratory animals. 
Species: Woman 
Dose: 20 MG/KG 
Route of Application: Oral 
Exposure Time: (34-25W PREG) 
Result: Effects on Newborn: Apgar score (human only). Effects on 
Newborn: Physical. 
Species: Rat 
Dose: 24 MG/KG 
Route of Application: Oral 
Exposure Time: (9-14D PREG) 
Result: Effects on Newborn: Growth statistics (e.g., reduced 
weight gain). 
Species: Rat 
Dose: 15 MG/KG 
Route of Application: Intramuscular 
Exposure Time: (5-19D PREG) 
Result: Effects on Newborn: Biochemical and metabolic. 
Species: Mouse 
Dose: 24 MG/KG 
Route of Application: Oral 
Exposure Time: (7-12D PREG) 
Result: Maternal Effects: Other effects. Effects on Embryo or 
Fetus: Fetotoxicity (except death, e.g., stunted fetus). Effects 
on Newborn: Growth statistics (e.g., reduced weight gain). 
Species: Rabbit 
Dose: 10 MG/KG 
Route of Application: Oral 
Exposure Time: (1D PRE) 
Result: Effects on Fertility: Other measures of fertility 
SIGMA - D174 www.sigma-aldrich.com Page 5
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Contact a licensed professional waste disposal service to dispose 
of this material. Dissolve or mix the material with a combustible 
solvent and burn in a chemical incinerator equipped with an 
afterburner and scrubber. Observe all federal, state, and local 
environmental regulations. 
14 - Transport Information 
RID/ADR 
UN#: 2811 
Class: 6.1 
PG: III 
Proper Shipping Name: Toxic solid, organic, n.o.s. 
IMDG 
UN#: 2811 
Class: 6.1 
PG: III 
EmS Number: 6.1-04 
MFAG Number: 999 
Proper Shipping Name: Toxic solid, organic, n.o.s. 
Marine Pollutant: No 
Severe Marine Pollutant: No 
Technical Name: X 
IATA 
UN#: 2811 
Class: 6.1 
PG: III 
Proper Shipping Name: Toxic solid, organic, n.o.s. 
Inhalation Packing Group I: No 
Technical Name: X 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
INDICATION OF DANGER: T 
Toxic. 
R-PHRASES: 25 
Toxic if swallowed. 
S-PHRASES: 22 36/37 45 
Do not breathe dust. Wear suitable protective clothing and 
gloves. In case of accident or if you feel unwell, seek medical 
advice immediately (show the label where possible). 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
SIGMA - D174 www.sigma-aldrich.com Page 6
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
SIGMA - D174 www.sigma-aldrich.com Page 7