Dicoumarol
Identification of the substance/preparation and of the company/undertaking
SAFETY DATA SHEET
Product name
Conforms to 93/112/EC and ISO 11014-1
1.
Emergency
telephone number
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Chemical formula C19H12O6
Manufactured by EMD Biosciences, Inc.
10394 Pacific Center Court
San Diego, CA 92121
(858)450-5558/(800)854-3417
FAX: (858)453-3552
Supplier
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Call ChemtrecŪ
(800)424-9300 (within U.S.A.)
(703)527-3887 (outside U.S.A.)
Order
Number
Customer
Number
Catalog # : 287897
Synonym 3,3'-Methylenebis(4-hydroxycoumarin); Dicumarol;
Bis-Hydroxycoumarin
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Composition / information on ingredients 2.
Substance/Preparation Substance :
CAS No. Chemical name* EC Number Symbol R-Phrases
1) 3,3'-Methylenebis(4-hydroxycoumarin); Dicumarol;
Bis-Hydroxycoumarin
66-76-2 Not available. T, N R25, R51/53
Hazards identification 3.
Physical/chemical hazards
Human health hazards WARNING!
Not applicable. :
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BIRTH DEFECT HAZARD
CONTAINS MATERIAL WHICH CAN CAUSE BIRTH DEFECT.
TOXIC TO AQUATIC ORGANISMS.
MAY BE HARMFUL IF SWALLOWED.
MAY CAUSE DAMAGE TO THE FOLLOWING ORGANS: REPRODUCTIVE SYSTEM.
MAY BE HARMFUL TO ENVIRONMENT IF RELEASED IN LARGE AMOUNTS.
Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
tight clothing such as a collar, tie, belt or waistband.
Skin Contact
Ingestion
Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention.
In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes.
Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
4.
Hazardous in case of ingestion.
Aggravating conditions Repeated or prolonged exposure is not known to aggravate medical condition.
First-Aid measures
If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Ingestion
Effects and symptoms
Inhalation
Eye Contact
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First-aid measures
Fire-fighting measures 5.
Suitable
Hazardous thermal (de)composition
products
These products are carbon oxides (CO, CO2).
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Extinguishing Media
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Flammability of the Product May be combustible at high temperature. :
Page: 1/4 Catalog # 287897
Fire fighters should wear positive pressure self-contained breathing apparatus (SCBA) and full turnout gear.
Be sure to use an approved/certified respirator or equivalent. Protection of fire-fighters
Special fire-fighting procedures :
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Personal precautions Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
6. Accidental release measures
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: Small Spill and Leak Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Use a shovel to put the material into a convenient waste disposal container. Large Spill and Leak :
Handling
Handling and storage
Storage
7.
Keep locked up. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk,
evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not
breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and show the
container or the label. Keep away from incompatibles such as oxidizing agents.
Packaging materials
Use original container.
Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 4°C (39.2°F).
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Recommended use
Ingredient Name Occupational Exposure Limits
Engineering measures Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure
to airborne contaminants below the exposure limit.
1) Dicoumarol Not available.
8. Exposure controls/personal protection
Wash hands, forearms, and face thoroughly after handling compounds and before eating, smoking, using
lavatory, and at the end of day.
Hygiene measures
Skin and body
Personal protective equipment
Wear appropriate respirator when ventilation is inadequate.
Lab coat.
Safety glasses. Eyes
Respiratory system
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Protective Clothing
(Pictograms)
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Physical and chemical properties
Physical state
Melting Point
Solubility
Solid. (Solid crystalline powder.)
290 to 292°C (554 to 557.6°F)
Not available.
White. Color
Flash point Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
9.
Explosive properties
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Molecular Weight 336.3 g/mole :
Hazardous Decomposition Products
Conditions to avoid Sensitive to light.
Stability and reactivity
These products are carbon oxides (CO, CO2).
The product is stable. Stability
10.
Reactive with oxidizing agents.
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Materials to avoid :
Page: 2/4 Catalog # 287897
Specific effects
Acute oral toxicity (LD50): 250 mg/kg [Rat].
Toxicological information
Acute toxicity
Carcinogenic effects
Skin irritation
Mutagenic effects
Reproduction toxicity
Not available.
Not available.
Not available.
Classified Reproductive system/toxin/female, Reproductive system/toxin/male [SUSPECTED].
Repeated or prolonged exposure is not known to aggravate medical condition.
Not available.
11.
Local effects
Chronic toxicity
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Teratogenic effects :
RTECS # : GN7875000
Other Toxic Effects on
Humans Hazardous in case of ingestion.
Toxic for humans or animal life.
Not available.
Not available.
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Ecological information
Ecotoxicity Not available.
12.
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Toxicity of the Products of
Biodegradation
The products of degradation are less toxic than the product itself. :
Disposal considerations 13.
Methods of disposal; Waste of
residues; Contaminated packaging
Waste must be disposed of in accordance with federal, state and local environmental control regulations. :
ADR/RID Class
14.
International transport regulations
UN number
Land - Road/Railway
Toxic solid, organic, n.o.s.*
CLASS 6.1: Toxic substance.
Proper shipping name
UN2811
Packing Group III
ADR/RID label
IMDG Class
Sea
Toxic solid, organic, n.o.s.*
CLASS 6.1: Toxic substance.
Packing Group III
IMDG label
6
UN/ID Number
Air
Toxic solid, organic, n.o.s.*
UN2811
IATA-DGR Class
6
IATA label
CLASS 6.1: Toxic substance.
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Transport information
Proper shipping name
Proper shipping name
Special Provisions for
Transport
Not available. :
Page: 3/4 Catalog # 287897
Regulatory information 15.
Safety Phrases S37- Wear suitable gloves.
S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
S61- Avoid release to the environment. Refer to special instructions/Safety data sheets.
R25- Toxic if swallowed.
R51/53- Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Hazard symbol(s)
Risk Phrases
EU Regulations
Contains - Dicoumarol
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Classification : Toxic, Dangerous for the environment
Clean Water Act (CWA) 307: No products were found.
U.S. Federal Regulations
CLASS: Highly toxic.
CLASS: Target organ effects.
CLASS: Reproductive toxins.
HCS Classification
TSCA: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
No products were found.
WHMIS (Canada) CLASS D-1B: Material causing immediate and serious toxic effects (TOXIC).
CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found.
SARA 313 toxic chemical notification and release reporting: No products were found.
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State Regulations California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: Dicoumarol
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Other information 16.
Date of issue
3/5/2003. Page: 4/4
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its
subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be
used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.
Notice to Reader
Catalog # 287897
Hazardous Material
Information System
(U.S.A.)
3
1
0
0
1
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* National Fire
Protection
Association (U.S.A.) Health
Specific Hazard
Reactivity
Fire Hazard
Health
Fire Hazard
Reactivity
Personal Protection a