ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC -- FLUMAZENIL -- 6850-00F049005 ======================================================= MSDS Safety Information ======================================================= FSC: 6850 MSDS Date: 06/01/1994 MSDS Num: BZVFT LIIN: 00F049005 Tech Review: 07/15/1996 Product ID: FLUMAZENIL Responsible Party Cage: GO581 Name: ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC Address: 340 KINGSLAND STREET City: NUTLEY NJ 07110-1199 US Info Phone Number: 800-526-6367 Emergency Phone Number: 201-235-6660 Preparer's Name: HESHAM M SOLIMAN ======================================================= Preparer Co. when other than Responsible Party Co. ======================================================= Cage: GO581 Assigned Ind: Y Name: ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC Address: 340 KINGSLAND STREET City: NUTLEY NJ 07110-1199 ======================================================= Contractor Summary ======================================================= Cage: GO581 Name: ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC Address: 340 KINGSLAND STREET City: NUTLEY NJ 07110-1199 US Phone: 800-526-6367 ======================================================= Ingredients ======================================================= Cas: 78755-81-4 RTECS #: NI2922170 Name: FLUMAZENIL *96-2* % by Wt: >98 ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: ORAL LD50(RAT): 4200 MG/KG Route Of Entry Inds - Inhalation: YES Skin: NO Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: MAY CAUSE CENTRAL NERVOUS SYSTEM & CARDIOVASCULAR EFFECTS. MATERIAL MAY AFFECT THE DEVELOPING FETUS, FEMALES PLANNING TO HAVE CHILDREN & PREGNANT WOMEN, NURSING MOTHERS SHOULD USE CAUTION REGARDING EX POSURE. Explanation Of Carcinogenicity: NONE Signs And Symptions Of Overexposure: MATERIAL MAY AFFECT THE DEVELOPING FETUS, FEMALES PLANNING TO HAVE CHILDREN, PREGNANT WOMEN & NURSING MOTHERS SHOULD USE CAUTION REGARDING EXPOSURE. First Aid: INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED. SKIN: WASH W/SOAP & PLENTY OF WATER. EYES: FLUSH W/PLENTY OF WATER. INGESTION: DON'T INDUCE VOMITING, UNLESS DIRECTED BY MEDICAL PERSONNEL. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. OBTAIN MEDICAL ATTENTION IN ALL CASES. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: SHUT OFF IGNITION SOURCES SAFELY. SCOOP/SHOVEL MATERIAL INTO A SUITABLE LABELED OPEN HEAD DRUM. SECURE THE DRUM COVER & MOVE THE CONTAINER TO A SAFE HOLDING AREA. MOP/FLUSH THE AREA. Waste Disposal Methods: PRODUCT IS SUITABLE FOR INCINERATION. USE, PROCESSING, ALTERATION/CONTAMINATION MAY AFFECT DISPOSAL RECOMMENDATIONS. DISPOSE OF IAW/FEDERAL, STATE & LOCAL REGULATIONS. Handling And Storage Precautions: STORE AT 59-86F. DON'T HEAT >320F, GENERATE DUST/EXPOSE TO IGNITION SOURCES. GROUND & BOND TRANSFER EQUIPMENT. AVOID IGNITION SOURCES. Other Precautions: MILLING/MIXING/DRYING, PERFORM IN DEVICES EQUIPPED W/EXPLOSION RELIEF/SUPPRESSION SYSTEMS/UNDER INERT CONDITIONS. AVOID CONTACT W/EYES, SKIN & CLOTHING, BREATHING DUST. USE ADEQUATE VENTILATION. STORE IN COOL, DRY AREA. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER, CO2, DRY CHEMICAL, FOAM. Fire Fighting Procedures: WEAR NIOSH/MSHA APPROVED POSITIVE PRESSURE, SCBA & FULL PROTECTIVE TURN OUT GEAR. USE WATER TO COOL CONTAINERS. Unusual Fire/Explosion Hazard: SEVERE DUST EXPLOSION HAZARD. TOXIC & CORROSIVE EMISSIONS MAY BE GIVEN OFF IN A FIRE. ======================================================= Control Measures ======================================================= Respiratory Protection: NEGATIVE PRESSURE AIR PURIFYING, HALF FACE, TOXIC DUST/MIST/FUME HIGH EFFICIENCY FILTER. Ventilation: LOCAL VENTILATION. USE IN A LAB HOOD. Protective Gloves: LATEX, PLASTIC/RUBBER Eye Protection: SAFETY GLASSES/GOGGLES Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES BEFORE REUSE. Supplemental Safety and Health: HANDLING & STORAGE CONT'D: KEEP CONTAINER TIGHTLY CLOSED WHEN NOT IN USE. ======================================================= Physical/Chemical Properties ======================================================= M.P/F.P Text: 388-395.6F Appearance and Odor: WHITE TO OFF-WHITE POWDER W/NO ODOR. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Stability Condition To Avoid: ELEVATED TEMP, WATER, DUST ACCUMULATION, AIRBORNE DUST, IGNITION SOURCES, TEMP >212F. Hazardous Decomposition Products: CO, CO2, OXIDES OF NITROGEN, HYDROGEN FLUORIDE. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= ======================================================= Ecological Information ======================================================= ======================================================= MSDS Transport Information ======================================================= ======================================================= Regulatory Information ======================================================= ======================================================= Other Information ======================================================= ======================================================= HAZCOM Label ======================================================= Product ID: FLUMAZENIL Cage: GO581 Company Name: ROCHE DERMATOLOGICS DIV OF HOFFMANN-LA ROCHE INC Street: 340 KINGSLAND STREET City: NUTLEY NJ Zipcode: 07110-1199 US Health Emergency Phone: 201-235-6660 Date Of Label Review: 12/16/1998 Label Date: 12/16/1998 Hazard And Precautions: MAY CAUSE CENTRAL NERVOUS SYSTEM & CARDIOVASCULAR EFFECTS. MATERIAL MAY AFFECT THE DEVELOPING FETUS, FEMALES PLANNING TO HAVE CHILDREN & PREGNANT WOMEN, NURSING MOTHERS SHOULD USE CAUTION REGARDING EX POSURE. MATERIAL MAY AFFECT THE DEVELOPING FETUS, FEMALES PLANNING TO HAVE CHILDREN, PREGNANT WOMEN & NURSING MOTHERS SHO ULD USE CAUTION REGARDING EXPOSURE. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.