SIGMA CHEMICAL CO -- FOLIC ACID, F7876 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 04/01/1999 MSDS Num: CJTSL LIIN: 00N092716 Product ID: FOLIC ACID, F7876 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-71-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Ingredients ======================================================= Cas: 59-30-3 RTECS #: LP5425000 Name: FOLIC ACID Percent by Wt: 100. Other REC Limits: N/K (FP N) OSHA PEL: N/K (FP N) OSHA STEL: N/K (FP N) ACGIH TLV: N/K (FP N) ACGIH STEL: N/K (FP N) ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE TOXICOLOGICAL INFORMATION. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE IRRITATION. TO THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN TH OROUGHLY INVESTIGATED. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE AR TIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL SI TE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. DO NOT IN EYES, ON SKIN, ON CLOTHING. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: WEAR NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). ======================================================= Control Measures ======================================================= Respiratory Protection: NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: RUBBER GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: EYEWASH AND DELUGE SHOWER MEETING ANSI DESIGN CRITERIA (FP N). Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. ======================================================= Physical/Chemical Properties ======================================================= Appearance and Odor: YELLOW-ORANGE POWDER. ======================================================= Reactivity Data ======================================================= Stability Condition To Avoid: MAY DECOMPOSE ON EXPOSURE TO LIGHT. Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: TOXIC FUMES OF CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES. ======================================================= Toxicological Information ======================================================= Toxicological Information: RTECS # LP5425000, FOLIC ACID. TOX DATA: IVN-RAT LD50: 500MG/KG; NIIRDN-, 1409, 1995. ORL-MUS LD50: 10GM/KG; TXAPA9 23, 537, 1972. IPR-MUS LD50: 85MG/KG; EXPEAM 41, 72, 1985. IVN-MUS LD50: 282MG/KG; T XAPA9 23, 537, 1972. IVN-RBT LD50: 410MG/KG; NIIRDN-, 1409, 1995. IVN-GPG LD50: 120MG/KG; NIIRDN-, 1409, 1995. TARGET ORGAN DATA: BEHAVIORAL (CONVLS/EFT ON SEIZURE THRESHOLD, MUSC WEAK, COMA); KIDNEY, URETER, BLADDER (OTHER CHANGES); BLOOD (CHANGES IN SPLEEN); EFTS ON EMBRYO/FETUS (CYTOLOGICAL CHANGES). ONLY SELECTED REGISTRY OF TOX EFTS OF CHEM SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUA L ENTRY IN RTECS FOR COMPLETE INFO. ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: REVIEWS, STANDARDS, AND REGULATIONS: OEL = MAK. NOHS 1974: HZD M1051; NIS 4; TNF 220; NOS 14; TNE 11106. NOES 1983: HZD M1051; NIS 11; TNF 2823; NOS 40; TNE 60281; TFE 29903. EPA TSCA SECTION 8 (B) IN VENTORY. ======================================================= Other Information ======================================================= Other Information: INGREDIENT INFORMATION: MF: C*19H*19N*7O*6. EC NO: 200-419-0. HAZARDS IDENTIFICATION: DATA NOT AVAILABLE. ======================================================= HAZCOM Label ======================================================= Product ID: FOLIC ACID, F7876 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-71-5765 Label Required IND: Y Date Of Label Review: 10/28/1999 Status Code: A Origination Code: F Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Moderate Fire Hazard: Slight Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE IRRITATION. CHRONIC: NONE LISTED BY MANUFACTURER. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.