SIGMA CHEMICAL CO -- GENTAMICIN SULFATE PLANT CELL CULTURE TESTED, ======================================================= MSDS Safety Information ======================================================= FSC: 6550 MSDS Date: 07/01/1999 MSDS Num: CJTLK LIIN: 00N092586 Product ID: GENTAMICIN SULFATE PLANT CELL CULTURE TESTED, G6896 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Ingredients ======================================================= Cas: 1405-41-0 RTECS #: LY2625000 Name: GENTAMICIN SULFATE Percent by Wt: 100. Other REC Limits: N/K (FP N) OSHA PEL: N/K (FP N) OSHA STEL: N/K (FP N) ACGIH TLV: N/K (FP N) ACGIH STEL: N/K (FP N) ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE TOXICOLOGICAL INFORMATION. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. CAUSES EYE AND SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. AMINOGLYCOSIDES ARE ASSO CIATED WITH SIGNIFICANT NEPHROTOXICITY AND/OR OTOTOXICITY. PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. CAUSES PHOTOSENSITIVITY. EXPOSURE TO LIGHT CAN RESULT IN ALLERGIC REACTIONS RESULTING IN DERMATOLOGIC LESIONS, WHICH CAN VARY FROM SUNBURN-LIKE RESPONSES TO EDEMATOUS, VESICULATED LESIONS OR BULLAE. EXPOSURE CAN CAUSE NAUSEA, HEADACHE AND VOMITING . (EFFECTS OF OVEREXPOSURE) Signs And Symptions Of Overexposure: HEALTH HAZARDS: CHRONIC: MAY CAUSE CONGENITAL MALFORMATION IN THE FETUS. TARGET ORGANS: EARS, KIDNEYS, NERVES. TO THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPER TIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. First Aid: EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: EVACUATE AREA. WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AN D WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: NON-COMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: WEAR NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: USE ONLY IN A CHEMICAL FUME HOOD. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EMERGENCY EYEWASH AND DELUGE SHOWER (FP N). WEAR PROTECTIVE CLOTHING. Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. Supplemental Safety and Health: TOX INFO: TARGET ORGAN DATA: PERIPHERAL NERVE & SENSATION (SENSORY CHANGE INVOLVING PERIPHERAL NERVE); SENSE ORGANS & SPECIAL SENSES (PTOSIS); BEHAVIORAL (ALTERED SLEEP TIME, SOMNOLENCE, CONVLS/EFT ON SEIZURE THRESHOLD, MUSCLE CONTRACTION/SPASTICITY); LUNGS, THORAX/RESP (DYSPNAE, RESP STIMULATION, OTHER (ECOL INFO) ======================================================= Physical/Chemical Properties ======================================================= Solubility in Water: SOLUBLE Appearance and Odor: SOLID. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Hazardous Decomposition Products: TOXIC FUMES OF CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: RTECS #: LY2625000, GENTAMICIN, SULFATE. TOXICITY DATA: ORL-RAT LD50: >5 GM/KG; JZKEDZ 8, 219, 1982. IPR-RAT LD50: 630 MG/KG; JJANAX 26, 221, 1973. SCU-RAT LD50: 873 MG(BASE)/KG; ANKHEW 35 (9), 26, 19 90. IVN-RAT LD50: 96 MG/KG; JZKEDZ 8, 219, 1982. IMS-RAT LD50: 384 MG/KG; TXAPA9 18, 185, 1971. ORL-MUS LD50: >11269 MG/KG; NIIRDN 6, 268, 1982. IPR-MUS LD50: 245 MG/KG; JZKEDZ 8, 219, 1982. SCU-MUS L D50: 478 MG/KG; JANTAJ 23, 551, 1970. IVN-MUS LD50: 47 MG/KG; JJANAX 39, 3164, 1986. IMS-MUS LD50: 250 MG/KG; JZKEDZ 8, 219, 1982. ICE-MUS LD50: 17300 UG/KG; NKRZAZ 15, 483, 1967. SCU-GPG LD50: 600 MG /KG; NKRZAZ 16, 105, 1968. (SUP DAT) ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. --SUPDAT: CHANGES); SPECIFIC DEVELOPMENT ABNORMALITIES (CARDIOVASCULAR SYSTEM, UROGENITAL SYSTEM); EFFECTS ON NEWBORN (GROWTH STATISTICS, BIOCHEMICAL & METABOLIC); NUTRITIONAL & GROSS METABOLIC (CHANGES IN: OTHER METALS). ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: EUROPEAN INFORMATION: TOXIC. R 61: MAY CAUSE HARM TO THE UNBORN CHILD. R 36/38: IRRITATING TO EYES AND SKIN. R 42/43: MAY CAUSE SENSITIZATION BY INHALATION AND SKIN CONTACT. S 45: IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW LABEL WHERE POSSIBLE). S 36/37/39: WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. S 22: DO NOT BREATHE DUST. REVIEWS, S TANDARDS, AND REGULATIONS: OEL=MAK. NOES 1983: HZD X3126; NIS 7; TNF 2125; NOS 22; TNE 46715; TFE 34 072. ======================================================= Other Information ======================================================= Other Information: INGREDIENT INFORMATION: EC NO: 215-778-9. LABEL PRECAUTIONARY STATEMENTS: TOXIC. MAY CAUSE HARM TO THE UNBORN CHILD. IRRITATING TO EYES AND SKIN. MAY CAUSE SENSITIZATION BY INHALATION AND SKIN CONTACT . TARGET ORGAN(S): EARS, KIDNEYS. PHOTOSENSITIZER. IN CASE OF ACCIDENTOF IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE). WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. DO NOT BREATHE DUST. ======================================================= HAZCOM Label ======================================================= Product ID: GENTAMICIN SULFATE PLANT CELL CULTURE TESTED, G6896 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 11/22/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Moderate Fire Hazard: Slight Reactivity Hazard: None Hazard And Precautions: TOXIC. MAY CAUSE HARM TO THE UNBORN CHILD. ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. CAUSES EYE AND SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. EXPOSURE CAN CAUSE NAUSEA, HEADACHE AND VOMITING. CHRONIC: PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. CAUSES PHOTOSENSITIVITY. EXP OSURE TO LIGHT CAN RESULT IN ALLERGIC REACTIONS RESULTING IN DERMATOLOGIC LESIONS, WHICH CAN VARY FROM SUNBURN-LIKE RESPONSES TO EDEMATOUS, VESICULATED LESIONS OR BULLAE. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.