Material Safety Data Sheet **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: Gentamycin Sulfate Catalog Numbers: BP918 1, BP918-1, BP9181 Synonyms: Garamycin; Gentamicin Sulfate. Company Identification: Fisher Scientific 1 Reagent Lane Fairlawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 1405-41-0 |Gentamycin Sulfate | >99 | 215-778-9 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: None Listed. Risk Phrases: None Listed. **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: Exposure to solid may cause pain and redness. Skin: May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May be absorbed through the skin. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. Inhalation: May cause effects similar to those described for ingestion. Chronic: No information found. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Skin: Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a cool, dry area away from incompatible substances. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Solid Appearance: colorless to white Odor: none reported pH: 3.5-5.5, 4% solution Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 424-459F Autoignition Temperature: Not applicable. Flash Point: Not applicable. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Not available. Solubility: Soluble in water. Specific Gravity/Density: Not available. Molecular Formula: Not applicable. Molecular Weight: 0 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: High temperatures, incompatible materials, dust generation, excess heat. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, oxides of nitrogen, oxides of sulfur, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 1405-41-0: LY2625000 LD50/LC50: CAS# 1405-41-0: Oral, mouse: LD50 = >11269 mg/kg; Oral, rat: LD50 = >5 gm/kg. Carcinogenicity: Gentamycin Sulfate - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: No information available. Teratogenicity: Effects of Newborn: Biochemical and Metabolic, subcutaneous-rat TDLo=660mg/kg; Growth statistics, intra- peritoneal-rat TDLo=375mg/kg. Specific Developmental Abnormalities: Cardiovascular system and Urogenital, subcutaneous-rat TDLo=660mg/kg. Reproductive Effects: No information available. Neurotoxicity: Aminoglycoside antibiotics have the potential to cause auditory nerve damage and neuromuscular paralysis. Mutagenicity: No information available. Other Studies: See actual entry in RTECS for complete information. **** SECTION 12 - ECOLOGICAL INFORMATION **** Other No information available. **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT No information available Canadian TDG No information available. **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 1405-41-0 is not listed on the TSCA inventory. It is for research and development use only. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Gentamycin Sulfate is not present on state lists from CA, PA, MN, MA, FL, or NJ. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: WGK (Water Danger/Protection) CAS# 1405-41-0: 1 United Kingdom Occupational Exposure Limits Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 1405-41-0 is not listed on Canada's Ingredient Disclosure List. Exposure Limits **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 7/13/1999 Revision #1 Date: 8/02/2000 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------