=======================================================
MSDS Safety Information 
=======================================================

NAME: GMS OXIDIZER

=======================================================

MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
VENTANA MEDICAL SYSTEMS INC. EMERGENCY TELEPHONE NUMBER:
1910 E. Innovation Park Drive (800) 424-9300 (USA/Canada)
Tucson, Arizona 85755 (CHEMTREC)
(520) 887-2155 +1 (703) 527-3887 (International)
MSDS NUMBER: 00231578
SUBSTANCE: GMS Oxidizer
PRODUCT NUMBER(S): 1521900
PRODUCT USE: clinical/research
CREATION DATE: Feb 07 2006
REVISION DATE: Mar 05 2009
2. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=0 REACTIVITY=0
EC CLASSIFICATION:
O Oxidizing
T Toxic
Xn Harmful
C Corrosive
Xi Irritant
Carcinogen Category 1
Mutagen Category 2
Reproductive Toxin Category 3
RISK PHRASES:
R 8 Contact with combustible material may cause fire.
R 21/22 Harmful in contact with skin and if swallowed.
R 23 Toxic by inhalation.
R 34 Causes burns.
R 37 Irritating to respiratory system.
R 42/43 May cause sensitization by inhalation and skin contact.
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
R 48/20 Harmful: danger of serious damage to health by prolonged exposure through inhalation.
R 62 Possible risk of impaired fertility.
EMERGENCY OVERVIEW:
COLOR: orange
PHYSICAL FORM: liquid
ODOR: odorless
MAJOR HEALTH HAZARDS: harmful if swallowed, respiratory tract irritation, skin irritation, eye
irritation, allergic reactions, kidney damage, cancer hazard (in humans)
PHYSICAL HAZARDS: May ignite combustibles.
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: irritation, allergic reactions, cough, lung congestion, sore throat, chest pain,
headache, loss of voice, wheezing, difficulty breathing, weight loss, fever
LONG TERM EXPOSURE: irritation, allergic reactions, bleeding, tooth decay, tooth discoloration,
gastrointestinal effects, headache, dizziness, drowsiness, loss of coordination, blood disorders, kidney
damage, lung damage, liver damage, cancer
SKIN CONTACT:
SHORT TERM EXPOSURE: irritation, allergic reactions, absorption may occur, nausea, vomiting, kidney
damage, coma
LONG TERM EXPOSURE: irritation, allergic reactions, skin disorders, sensitivity to sunlight, absorption
may occur, kidney damage
EYE CONTACT:
SHORT TERM EXPOSURE: irritation, blurred vision, blindness
LONG TERM EXPOSURE: irritation, tearing
INGESTION:
SHORT TERM EXPOSURE: irritation, nausea, vomiting, thirst, dizziness, muscle cramps, kidney damage,
convulsions, coma
LONG TERM EXPOSURE: irritation, kidney damage
3. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT: NON-HAZARDOUS
CAS NUMBER: Not assigned.
EC NUMBER: Not assigned.
PERCENTAGE: 60-100
EC CLASSIFICATION: No classification assigned.
COMPONENT: CHROMIC ANHYDRIDE
CAS NUMBER: 1333-82-0
EC NUMBER (EINECS): 215-607-8
PERCENTAGE: 5-10
EC CLASSIFICATION: O; T+; T; C; Sensitizing; N; Carcinogen Category 1; Mutagen Category 2;
Reproductive Toxin Category 3
RISK PHRASES: 9-24/25-26-35-42/43-45-46-48/23-50/53-62
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not
breathing. Get immediate medical attention.
SKIN CONTACT: Wash contaminated areas with soap and water. Thoroughly clean and dry contaminated
clothing before reuse. Get medical attention, if needed.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical
attention.
INGESTION: If a large amount is swallowed, get medical attention.
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Negligible fire hazard. Oxidizer. May ignite or explode on contact
with combustible materials.
EXTINGUISHING MEDIA: regular dry chemical, soda ash, water
FIRE FIGHTING: Move container from fire area if it can be done without risk. Cool containers with water
spray until well after the fire is out. Flood with water. Apply water from a protected location or from a safe
distance.
SENSITIVITY TO MECHANICAL IMPACT: Not sensitive
SENSITIVITY TO STATIC DISCHARGE: Not sensitive
FLASH POINT: not flammable
6. ACCIDENTAL RELEASE MEASURES
WATER RELEASE:
Subject to California Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Keep out of
water supplies and sewers.
OCCUPATIONAL RELEASE:
Avoid contact with combustible materials. Do not touch spilled material. Small spills: Absorb with sand or
other non-combustible material. Collect spilled material in appropriate container for disposal. Keep
unnecessary people away, isolate hazard area and deny entry.
7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and standards. Store at room
temperature. NFPA 430 Code for the Storage of Liquid and Solid Oxidizing Materials. See original container
for storage recommendations. Keep separated from incompatible substances.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
CHROMIC ANHYDRIDE:
CHROMATES (soluble compounds):
0.1 mg(CrO3)/m3 OSHA ceiling (applies to operations/sectors for which the Hexavalent Chromium
29CFR1910.1026 is stayed)
2.5 ug(Cr(VI))/m3 OSHA action level 8 hour(s)
5 ug(Cr(VI))/m3 OSHA PEL 8 hour(s)
0.05 mg(Cr(VI))/m3 ACGIH TWA
0.001 mg(Cr(VI))/m3 NIOSH recommended TWA 10 hour(s)
DFG MAK (skin sensitizer) (inhalable fraction)
0.1 mg/m3 AGS TRK (effective 1 Jan 2005 no longer valid per amendment) (welding fumes) (production)
0.05 mg/m3 AGS TRK (effective 1 Jan 2005 no longer valid per amendment) (other operations)
0.05 mg(Cr)/m3 UK WEL TWA (airway sensitizer)
VENTILATION: Provide adequate ventilation. Ensure compliance with applicable exposure limits.
EYE PROTECTION: Safety glasses or goggles are recommended when there is a potential for eye contact.
Provide an emergency eye wash fountain and quick drench shower in the immediate work area.
CLOTHING: Lab coat or apron.
GLOVES: Wear appropriate chemical resistant gloves.
PROTECTIVE MATERIAL TYPES: latex, vinyl, nitrile
RESPIRATOR: No respirator is required under normal conditions of use.
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
APPEARANCE: clear
COLOR: orange
ODOR: odorless
BOILING POINT: Not available
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY: Not available
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: miscible
PH: acidic
VOLATILITY: Not available
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: Avoid contact with combustible materials. May ignite or explode on contact
with combustible materials. Keep out of water supplies and sewers.
INCOMPATIBILITIES: finely powdered metals, phosphorus, organic solvents and compounds, hydrogen
sulfide, arsenic, ammonia, potassium, sodium, selenium, dimethylformamide
HAZARDOUS DECOMPOSITION:
Thermal decomposition products: miscellaneous decomposition products
POLYMERIZATION: Will not polymerize.
11. TOXICOLOGICAL INFORMATION
CHROMIC ANHYDRIDE:
TOXICITY DATA: 80 mg/kg oral-rat LD50
CARCINOGEN STATUS: NTP: Known Human Carcinogen; IARC: Human Sufficient Evidence, Animal
Limited Evidence, Group 1; ACGIH: A1 -Confirmed Human Carcinogen (Hexavalent chromium
compounds); EC: Category 1; TRGS 905: K 1
LOCAL EFFECTS:
Corrosive: inhalation, skin, eye, ingestion
ACUTE TOXICITY LEVEL:
Toxic: ingestion
TARGET ORGANS: immune system (sensitizer), kidneys
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: blood system disorders, heart or
cardiovascular disorders, liver disorders, respiratory disorders, skin disorders and allergies
ADDITIONAL DATA: May be excreted in breast milk.
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations. Subject to disposal regulations: U.S. EPA 40 CFR 262.
Hazardous Waste Number(s): D001. Hazardous Waste Number(s): D007. Dispose of in accordance with U.S.
EPA 40 CFR 262 for concentrations at or above the Regulatory level. Regulatory level- 5.0 mg/L.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: Not regulated.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: Not regulated.
LAND TRANSPORT ADR: Not regulated.
LAND TRANSPORT RID: Not regulated.
AIR TRANSPORT IATA: Not regulated.
AIR TRANSPORT ICAO: Not regulated.
MARITIME TRANSPORT IMDG: Not regulated.
15. REGULATORY INFORMATION
U.S. REGULATIONS:
CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR 302.4):
CHROMIC ACID (SOLUTIONS): 10 LBS RQ
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart
B): Not regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart
C): Not regulated.
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370 Subparts B
and C):
ACUTE: Yes
CHRONIC: Yes
FIRE: Yes
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65):
Chromium Compounds
STATE REGULATIONS:
California Proposition 65:
Known to the state of California to cause the following:
Hexavalent Chromium Compounds
Cancer (Feb 27, 1987)
Developmental toxicity (Dec 19, 2008)
Male reproductive toxicity (Dec 19, 2008)
Female reproductive toxicity (Dec 19, 2008)
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: C, D2A, D2B.
EUROPEAN REGULATIONS:
EC CLASSIFICATION (CALCULATED):
O Oxidizing
T Toxic
Xn Harmful
C Corrosive
Xi Irritant
Carcinogen Category 1
Mutagen Category 2
Reproductive Toxin Category 3
DANGER/HAZARD SYMBOL:
EC RISK AND SAFETY PHRASES:
R 8 Contact with combustible material may cause fire.
R 21/22 Harmful in contact with skin and if swallowed.
R 23 Toxic by inhalation.
R 34 Causes burns.
R 37 Irritating to respiratory system.
R 42/43 May cause sensitization by inhalation and skin contact.
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
R 48/20 Harmful: danger of serious damage to health by prolonged exposure through inhalation.
R 62 Possible risk of impaired fertility.
S 17 Keep away from combustible material.
S 24/25 Avoid contact with skin and eyes.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical
advice.
S 27 Take off immediately all contaminated clothing.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S 38 In case of insufficient ventilation, wear suitable respiratory equipment.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label
where possible).
S 53 Avoid exposure - obtain special instructions before use.
S 60 This material and its container must be disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to special instructions/Safety data sheets.
16. OTHER INFORMATION
EC RISK PHRASES:
R 8 Contact with combustible material may cause fire.
R 9 Explosive when mixed with combustible material.
R 21/22 Harmful in contact with skin and if swallowed.
R 23 Toxic by inhalation.
R 24/25 Toxic in contact with skin and if swallowed.
R 26 Very toxic by inhalation.
R 34 Causes burns.
R 35 Causes severe burns.
R 37 Irritating to respiratory system.
R 42/43 May cause sensitization by inhalation and skin contact.
R 45 May cause cancer.
R 46 May cause heritable genetic damage.
R 48/20 Harmful: danger of serious damage to health by prolonged exposure through inhalation.
R 48/23 Toxic: danger of serious damage to health by prolonged exposure through inhalation.
R 50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.
R 62 Possible risk of impaired fertility.
“RTECS®” is a United States trademark owned and licensed under authority of the U.S. Government, by
and through Symyx Software, Inc. Portions ©Copyright 2001, U.S. Government. All rights reserved.
Limitations: The information and recommendations set forth in this MSDS are believed to be correct
as of this date. Ventana Medical Systems, Inc. makes no warranty with respect to the content of this
MSDS and disclaims all liability from reliance thereon.