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MSDS Safety Information 
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NAME: GMS SILVER (A AND B)

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MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
VENTANA MEDICAL SYSTEMS INC. EMERGENCY TELEPHONE NUMBER:
1910 E. Innovation Park Drive (800) 424-9300 (USA/Canada)
Tucson, Arizona 85755 (CHEMTREC)
(520) 887-2155 +1 (703) 527-3887 (International)
MSDS NUMBER: 00231579
SUBSTANCE: GMS Silver A
PRODUCT NUMBER(S): 152200, 1562700
PRODUCT USE: clinical/research
CREATION DATE: Feb 07 2006
REVISION DATE: Mar 05 2009
2. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=0 REACTIVITY=0
EC CLASSIFICATION:
No classification assigned.
EMERGENCY OVERVIEW:
COLOR: colorless
PHYSICAL FORM: liquid
ODOR: odorless
MAJOR HEALTH HAZARDS: respiratory tract irritation, skin irritation, eye irritation
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: irritation, sore throat, cough, difficulty breathing, lung damage
LONG TERM EXPOSURE: skin disorders
SKIN CONTACT:
SHORT TERM EXPOSURE: irritation, skin discoloration
LONG TERM EXPOSURE: skin discoloration
EYE CONTACT:
SHORT TERM EXPOSURE: irritation, eye damage, blindness
LONG TERM EXPOSURE: irritation, eye damage, blindness
INGESTION:
SHORT TERM EXPOSURE: irritation, stomach pain, vomiting, diarrhea, dizziness, convulsions, coma,
kidney damage, liver damage
LONG TERM EXPOSURE: skin disorders, blood disorders
3. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT: NON-HAZARDOUS
CAS NUMBER: Not assigned.
EC NUMBER: Not assigned.
PERCENTAGE: 60-100
EC CLASSIFICATION: No classification assigned.
COMPONENT: SILVER NITRATE
CAS NUMBER: 7761-88-8
EC NUMBER (EINECS): 231-853-9
PERCENTAGE: 0.5-1.5
EC CLASSIFICATION: C; N
RISK PHRASES: 34-50/53
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not
breathing. Get immediate medical attention.
SKIN CONTACT: Wash contaminated areas with soap and water. Thoroughly clean and dry contaminated
clothing before reuse. Get medical attention, if needed.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical
attention.
INGESTION: If a large amount is swallowed, get medical attention.
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Negligible fire hazard.
EXTINGUISHING MEDIA: Use extinguishing agents appropriate for surrounding fire.
FIRE FIGHTING: Move container from fire area if it can be done without risk. Avoid inhalation of
material or combustion by-products.
SENSITIVITY TO MECHANICAL IMPACT: Not sensitive
SENSITIVITY TO STATIC DISCHARGE: Not sensitive
FLASH POINT: not flammable
6. ACCIDENTAL RELEASE MEASURES
OCCUPATIONAL RELEASE:
Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for
disposal.
7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and standards. Store between 2 C
and 8 C. See original container for storage recommendations. Keep separated from incompatible substances.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
SILVER NITRATE:
SILVER, SOLUBLE COMPOUNDS (as Ag):
0.01 mg/m3 OSHA TWA
0.01 mg/m3 ACGIH TWA
0.01 mg/m3 NIOSH recommended TWA 10 hour(s)
0.01 mg/m3 DFG MAK (peak limitation category - I, with excursion factor of 2) (inhalable fraction) (soluble
salts)
0.01 mg/m3 EC OEL TWA (IOELV)
0.01 mg(Ag)/m3 UK WEL TWA
VENTILATION: Provide adequate ventilation. Ensure compliance with applicable exposure limits.
EYE PROTECTION: Safety glasses or goggles are recommended when there is a potential for eye contact.
Provide an emergency eye wash fountain and quick drench shower in the immediate work area.
CLOTHING: Lab coat or apron.
GLOVES: Wear appropriate chemical resistant gloves.
PROTECTIVE MATERIAL TYPES: latex, nitrile, vinyl
RESPIRATOR: No respirator is required under normal conditions of use.
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
APPEARANCE: clear
COLOR: colorless
ODOR: odorless
BOILING POINT: Not available
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY: Not available
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: miscible
PH: neutral
VOLATILITY: Not available
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: None reported.
INCOMPATIBILITIES: oxidizing materials, reducing agents, acids, bases, ammonia, alcohols, magnesium
HAZARDOUS DECOMPOSITION:
Thermal decomposition products: miscellaneous decomposition products
POLYMERIZATION: Will not polymerize.
11. TOXICOLOGICAL INFORMATION
SILVER NITRATE:
IRRITATION DATA: 1 mg eyes-rabbit severe; 10 mg eyes-rabbit moderate
TOXICITY DATA: 1173 mg/kg oral-rat LD50
LOCAL EFFECTS:
Corrosive: inhalation, skin, eye, ingestion
ACUTE TOXICITY LEVEL:
Moderately Toxic: ingestion
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations. Hazardous Waste Number(s): D011. Dispose of in
accordance with U.S. EPA 40 CFR 262 for concentrations at or above the Regulatory level. Regulatory
level- 5.0 mg/L.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: Not regulated.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: Not regulated.
LAND TRANSPORT ADR: Not regulated.
LAND TRANSPORT RID: Not regulated.
AIR TRANSPORT IATA: Not regulated.
AIR TRANSPORT ICAO: Not regulated.
MARITIME TRANSPORT IMDG: Not regulated.
15. REGULATORY INFORMATION
U.S. REGULATIONS:
CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR 302.4):
SILVER NITRATE: 1 LBS RQ
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart
B): Not regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart
C): Not regulated.
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370 Subparts B
and C):
ACUTE: Yes
CHRONIC: No
FIRE: No
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65):
SILVER COMPOUNDS
STATE REGULATIONS:
California Proposition 65: Not regulated.
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: D2B.
EUROPEAN REGULATIONS:
EC CLASSIFICATION (CALCULATED):
No classification assigned.
16. OTHER INFORMATION
EC RISK PHRASES:
R 34 Causes burns.
R 50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment.
“RTECS®” is a United States trademark owned and licensed under authority of the U.S. Government, by
and through Symyx Software, Inc. Portions ©Copyright 2001, U.S. Government. All rights reserved.
Limitations: The information and recommendations set forth in this MSDS are believed to be correct
as of this date. Ventana Medical Systems, Inc. makes no warranty with respect to the content of this
MSDS and disclaims all liability from reliance thereon.

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MATERIAL SAFETY DATA SHEET
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION
VENTANA MEDICAL SYSTEMS INC. EMERGENCY TELEPHONE NUMBER:
1910 E. Innovation Park Drive (800) 424-9300 (USA/Canada)
Tucson, Arizona 85755 (CHEMTREC)
(520) 887-2155 +1 (703) 527-3887 (International)
MSDS NUMBER: 00231580
SUBSTANCE: GMS Silver B
PRODUCT NUMBER(S): 1522100
PRODUCT USE: clinical/research
CREATION DATE: Feb 07 2006
REVISION DATE: Mar 05 2009
2. HAZARDS IDENTIFICATION
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=0 REACTIVITY=0
EC CLASSIFICATION:
Xn Harmful
RISK PHRASES:
R 42/43 May cause sensitization by inhalation and skin contact.
EMERGENCY OVERVIEW:
COLOR: colorless
PHYSICAL FORM: liquid
ODOR: odorless
MAJOR HEALTH HAZARDS: respiratory tract irritation, skin irritation, eye irritation, central nervous
system depression, allergic reactions, kidney damage
POTENTIAL HEALTH EFFECTS:
INHALATION:
SHORT TERM EXPOSURE: irritation, cough, sore throat, difficulty breathing, allergic reactions, nausea,
vomiting, diarrhea, weakness, drowsiness, fever, headache, irregular heartbeat, tremors, dizziness, loss of
coordination, changes in body temperature, bluish skin color, changes in blood pressure, skin disorders,
convulsions, kidney damage, coma
LONG TERM EXPOSURE: allergic reactions, loss of voice, weight loss, nausea, vomiting, rash, skin
disorders, blood disorders, kidney damage, convulsions, reproductive effects
SKIN CONTACT:
SHORT TERM EXPOSURE: irritation, allergic reactions, absorption may occur, nausea, vomiting,
diarrhea, weakness, drowsiness, fever, headache, irregular heartbeat, tremors, dizziness, loss of coordination,
changes in body temperature, bluish skin color, changes in blood pressure, skin disorders, kidney damage,
convulsions, coma
LONG TERM EXPOSURE: irritation, allergic reactions, absorption may occur, weight loss, nausea,
vomiting, rash, blood disorders, skin disorders, convulsions, kidney damage, reproductive effects
EYE CONTACT:
SHORT TERM EXPOSURE: irritation, blurred vision, eye damage
LONG TERM EXPOSURE: irritation
INGESTION:
SHORT TERM EXPOSURE: irritation, nausea, vomiting, diarrhea, stomach pain, headache, irregular
heartbeat, bluish skin color, drowsiness, fever, tremors, weakness, dizziness, loss of coordination, changes in
body temperature, changes in blood pressure, skin disorders, kidney damage, convulsions, coma
LONG TERM EXPOSURE: irritation, rash, nausea, vomiting, diarrhea, stomach pain, weight loss, skin
disorders, blood disorders, convulsions, kidney damage, reproductive effects
3. COMPOSITION, INFORMATION ON INGREDIENTS
COMPONENT: NON-HAZARDOUS
CAS NUMBER: Not assigned.
EC NUMBER: Not assigned.
PERCENTAGE: 60-100
EC CLASSIFICATION: No classification assigned.
COMPONENT: HEXAMINE
CAS NUMBER: 100-97-0
EC NUMBER (EINECS): 202-905-8
PERCENTAGE: 10-30
EC CLASSIFICATION: F; Sensitizing
RISK PHRASES: 11-42/43
COMPONENT: SODIUM BORATE, ANHYDROUS
CAS NUMBER: 1330-43-4
EC NUMBER (EINECS): 215-540-4
PERCENTAGE: 1-5
EC CLASSIFICATION: Xn
RISK PHRASES: 22-36-37-38
4. FIRST AID MEASURES
INHALATION: If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not
breathing. If breathing is difficult, oxygen should be administered by qualified personnel. Get immediate
medical attention.
SKIN CONTACT: Wash contaminated areas with soap and water. Thoroughly clean and dry contaminated
clothing before reuse. Get medical attention, if needed.
EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical
attention.
INGESTION: If a large amount is swallowed, get medical attention.
NOTE TO PHYSICIAN: For inhalation, consider oxygen.
5. FIRE FIGHTING MEASURES
FIRE AND EXPLOSION HAZARDS: Negligible fire hazard.
EXTINGUISHING MEDIA: Use extinguishing agents appropriate for surrounding fire.
FIRE FIGHTING: Move container from fire area if it can be done without risk. Avoid inhalation of
material or combustion by-products.
SENSITIVITY TO MECHANICAL IMPACT: Not sensitive
SENSITIVITY TO STATIC DISCHARGE: Not sensitive
FLASH POINT: not flammable
HAZARDOUS COMBUSTION PRODUCTS:
Thermal decomposition or combustion products: oxides of boron, oxides of carbon
6. ACCIDENTAL RELEASE MEASURES
OCCUPATIONAL RELEASE:
Stop leak if possible without personal risk. Small spills: Absorb with sand or other non-combustible material.
Collect spilled material in appropriate container for disposal. Keep unnecessary people away, isolate hazard
area and deny entry.
7. HANDLING AND STORAGE
STORAGE: Store and handle in accordance with all current regulations and standards. Store at room
temperature. Store between 2 C and 8 C. See original container for storage recommendations. Keep
separated from incompatible substances.
8. EXPOSURE CONTROLS, PERSONAL PROTECTION
EXPOSURE LIMITS:
HEXAMINE:
DFG MAK (skin sensitizer)
SODIUM BORATE, ANHYDROUS:
10 mg/m3 OSHA TWA (vacated by 58 FR 35338, June 30, 1993)
1 mg/m3 NIOSH recommended TWA 10 hour(s)
1 mg/m3 UK WEL TWA
BORATE COMPOUNDS, INORGANIC:
2 mg/m3 ACGIH TWA (inhalable fraction)
6 mg/m3 ACGIH STEL (inhalable fraction)
VENTILATION: Provide adequate ventilation. Ensure compliance with applicable exposure limits.
EYE PROTECTION: Safety glasses or goggles are recommended when there is a potential for eye contact.
Provide an emergency eye wash fountain and quick drench shower in the immediate work area.
CLOTHING: Lab coat or apron.
GLOVES: Wear appropriate chemical resistant gloves.
PROTECTIVE MATERIAL TYPES: latex, vinyl, nitrile
RESPIRATOR: No respirator is required under normal conditions of use.
9. PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE: liquid
APPEARANCE: clear
COLOR: colorless
ODOR: odorless
BOILING POINT: Not available
FREEZING POINT: Not available
VAPOR PRESSURE: Not available
VAPOR DENSITY: Not available
SPECIFIC GRAVITY: Not available
WATER SOLUBILITY: miscible
PH: weakly basic
VOLATILITY: Not available
ODOR THRESHOLD: Not available
EVAPORATION RATE: Not available
COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available
10. STABILITY AND REACTIVITY
REACTIVITY: Stable at normal temperatures and pressure.
CONDITIONS TO AVOID: Protect from freezing. Keep separated from incompatible substances.
INCOMPATIBILITIES: potassium, acid anhydrides
HAZARDOUS DECOMPOSITION:
Thermal decomposition or combustion products: oxides of boron, oxides of carbon
POLYMERIZATION: Will not polymerize.
11. TOXICOLOGICAL INFORMATION
HEXAMINE:
TOXICITY DATA: 569 mg/kg oral-mouse LD50
LOCAL EFFECTS:
Irritant: inhalation, skin, eye
ACUTE TOXICITY LEVEL:
Moderately Toxic: ingestion
TARGET ORGANS: immune system (sensitizer)
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: kidney disorders, liver disorders
ADDITIONAL DATA: May be excreted in breast milk. Interactions with drugs may occur.
SODIUM BORATE, ANHYDROUS:
TOXICITY DATA: 1200 mg/kg oral-rat LD50
CARCINOGEN STATUS: ACGIH: A4 -Not Classifiable as a Human Carcinogen (Inorganic borate
compounds)
LOCAL EFFECTS:
Irritant: inhalation, skin, eye
ACUTE TOXICITY LEVEL:
Moderately Toxic: ingestion
TARGET ORGANS: central nervous system, kidneys
12. ECOLOGICAL INFORMATION
Not available
13. DISPOSAL CONSIDERATIONS
Dispose in accordance with all applicable regulations.
14. TRANSPORT INFORMATION
U.S. DEPARTMENT OF TRANSPORTATION: Not regulated.
CANADIAN TRANSPORTATION OF DANGEROUS GOODS: Not regulated.
LAND TRANSPORT ADR: Not regulated.
LAND TRANSPORT RID: Not regulated.
AIR TRANSPORT IATA: Not regulated.
AIR TRANSPORT ICAO: Not regulated.
MARITIME TRANSPORT IMDG: Not regulated.
15. REGULATORY INFORMATION
U.S. REGULATIONS:
CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR 302.4): Not regulated.
SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart
B): Not regulated.
SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart
C): Not regulated.
SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370 Subparts B
and C):
ACUTE: Yes
CHRONIC: Yes
FIRE: No
REACTIVE: No
SUDDEN RELEASE: No
SARA TITLE III SECTION 313 (40 CFR 372.65): Not regulated.
STATE REGULATIONS:
California Proposition 65: Not regulated.
CANADIAN REGULATIONS:
WHMIS CLASSIFICATION: D2A, D2B.
EUROPEAN REGULATIONS:
EC CLASSIFICATION (CALCULATED):
Xn Harmful
DANGER/HAZARD SYMBOL:
EC RISK AND SAFETY PHRASES:
R 42/43 May cause sensitization by inhalation and skin contact.
S 24 Avoid contact with skin.
S 37 Wear suitable gloves.
S 38 In case of insufficient ventilation, wear suitable respiratory equipment.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label
where possible).
S 60 This material and its container must be disposed of as hazardous waste.
16. OTHER INFORMATION
EC RISK PHRASES:
R 11 Highly flammable.
R 22 Harmful if swallowed.
R 36 Irritating to eyes.
R 37 Irritating to respiratory system.
R 38 Irritating to skin.
R 42/43 May cause sensitization by inhalation and skin contact.
“RTECS®” is a United States trademark owned and licensed under authority of the U.S. Government, by
and through Symyx Software, Inc. Portions ©Copyright 2001, U.S. Government. All rights reserved.
Limitations: The information and recommendations set forth in this MSDS are believed to be correct
as of this date. Ventana Medical Systems, Inc. makes no warranty with respect to the content of this
MSDS and disclaims all liability from reliance thereon.