======================================================= MSDS Safety Information ======================================================= NAME: GOMORI STAIN ======================================================= Gomori Trichrome Stain None. 623 Laboratory Reagent 800-424-9300 CHEMTREC (USA) 613-996-6666 CANUTEC (Canada) 24 Hours/Day: 7 Days/Week 7/12/2004 7/12/2004 Material Safety Data Sheet Product Name Synonym Material Uses Manufacturer Product Code Effective Date Print Date In Case of Emergency Call Section 1. Product and Company Identification For More Information Call 856-423-6300 Technical Service Monday-Friday: 8:00 AM - 5:00 PM Chemical Family Dye Solution EMD Chemicals Inc. P.O. Box 70 480 Democrat Road Gibbstown, NJ 08027 Prior to January 1, 2003 EMD Chemicals Inc. was EM Industries, Inc. or EM Science, Division of EM Industries, Inc. Section 2. Composition and Information on Ingredients Chromotrope 2R 4197-07-3 <1 Acetic Acid 64-19-7 1 Fast Green FCF 2353-45-9 0.3 Phosphotungstic Acid 12501-23-4 <1 Water 7732-18-5 >96 Component CAS # % by Weight Dermal contact. Eye contact. Inhalation. Ingestion. Emergency Overview Section 3. Hazards Identification Routes of Entry Potential Acute Health Effects Potential Chronic Health Effects Hazardous in case of inhalation (lung irritant). Hazardous in case of eye contact (irritant). Inflammation of the eye is characterized by redness, watering, and itching. Hazardous in case of ingestion. Hazardous in case of skin contact (permeator, irritant). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Eyes Skin Inhalation Ingestion Physical State and Appearance Liquid. WARNING ! CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION. HARMFUL IF INHALED, ABSORBED THROUGH SKIN OR SWALLOWED. CONTAINS MATERIAL WHICH MAY CAUSE CANCER BASED ON ANIMAL DATA. + Continued on Next Page Gomori Trichrome Stain 623 Page: 2/8 Medical Conditions Aggravated by Overexposure: Repeated or prolonged contact with spray mist may produce chronic eye irritation and severe skin irritation. Repeated or prolonged exposure to spray mist may produce respiratory tract irritation leading to frequent attacks of bronchial infection. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Carcinogenic Effects Classified 3 by IARC(Fast Green FCF) Additional information See Toxicological Information (section 11) If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. Get medical attention immediately. In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Cover the irritated skin with an emollient. Cold water may be used. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention immediately. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Section 4. First Aid Measures Eye Contact Skin Contact Inhalation Ingestion Not applicable. Non-flammable. Not applicable. Not applicable. Not applicable. Use DRY chemicals, CO2, water spray or foam. Not applicable. When heated to decomposition it emits highly toxic fumes. Risks of explosion of the product in presence of static discharge: No. Risks of explosion of the product in presence of mechanical impact: No. Thermal decomposition may release toxic and/or hazardous gases. Section 5. Fire Fighting Measures Flammability of the Product Auto-ignition Temperature Flash Points Flammable Limits Products of Combustion Fire Hazards in Presence of Various Substances Explosion Hazards in Presence of Various Substances Fire Fighting Media and Instructions Special Remarks on Fire Hazards Special Remarks on Explosion Hazards Protective Clothing (Fire) Wear suitable protective clothing. Continued on Next Page Gomori Trichrome Stain 623 Page: 3/8 Section 6. Accidental Release Measures Dilute with water and mop up, or absorb with an inert dry material and place in an appropriate waste disposal container. If necessary: Neutralize the residue with a dilute solution of sodium carbonate. Stop leak if without risk. Absorb with DRY earth, sand or other non-combustible material. Do not get water inside container. Do not touch spilled material. Use water spray curtain to divert vapor drift. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Call for assistance on disposal. Neutralize the residue with a dilute solution of sodium carbonate. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Small Spill and Leak Large Spill and Leak Spill Kit Information The following EMD Chemicals Inc. SpillSolv (TM) absorbent is recommended for this product: SX1310 Acid Treatment Kit Keep container tightly closed. Keep container in a cool, well-ventilated area. Store between 15 to 30°C (59 to 86°F). Avoid contact with eyes, skin and clothing. Do not ingest. Avoid breathing vapors or spray mists. Use only with adequate ventilation. Wash thoroughly after handling. Section 7. Handling and Storage Handling Storage Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective occupational exposure limits. Ensure that eyewash stations and safety showers are proximal to the work-station location. Splash goggles. Full suit. Vapor respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Chromotrope 2R Not available. Acetic Acid 80/1107/EEC (Europe, 1998). TWA: 25 mg/m3 TWA: 10 ppm INRS (France, 1999). VLE: 25 mg/m3 VLE: 10 ppm NIOSH REL (United States, 2000). STEL: 37 mg/m3 STEL: 15 ppm TWA: 25 mg/m3 Period: 10 hour(s). TWA: 10 ppm Period: 10 hour(s). OSHA Final Rule (United States, 1989). TWA: 25 mg/m3 Section 8. Exposure Controls/Personal Protection Engineering Controls Personal Protection in Case of a Large Spill Product Name Exposure Limits Vapor respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Face shield. Full suit. Gloves. Boots. Personal Protection Eyes Body Respiratory Hands Feet Protective Clothing (Pictograms) Continued on Next Page Gomori Trichrome Stain 623 Page: 4/8 TWA: 10 ppm AUVA (Austria, 1995). Spitzenbegrenzung: 50 mg/m3 8 times per shift, Period: 5 minute(s). Spitzenbegrenzung: 20 ML/M3 8 times per shift, Period: 5 minute(s). TWA: 25 mg/m3 TWA: 10 ML/M3 NOHSC (Australia, 1995). STEL: 37 mg/m3 STEL: 15 ppm TWA: 25 mg/m3 TWA: 10 ppm Lijst Grenswaarden (Belgium, 1998). VCD: 38 mg/m3 VCD: 15 ppm VL: 25 mg/m3 VL: 10 ppm SUVA (Switzerland, 1997). Momentanwert: 50 mg/m3 8 times per shift, Period: 5 minute(s). Momentanwert: 20 ML/M3 8 times per shift, Period: 5 minute(s). MAK: 25 mg/m3 8 times per shift, Period: 5 minute(s). MAK: 10 ML/M3 8 times per shift, Period: 5 minute(s). Ministry of Health (CL, 1992). CEIL: 37 mg/m3 TWA: 20 mg/m3 TWA: 8 ppm MAK-Werte Liste (Germany, 1998). Spitzenbegrenzung: 50 mg/m3 8 times per shift, Period: 5 minute(s). Spitzenbegrenzung: 20 ML/M3 8 times per shift, Period: 5 minute(s). MAK: 25 mg/m3 MAK: 10 ML/M3 TRGS900 (Germany, 1999). Spitzenbegrenzung: 25 mg/m3 Spitzenbegrenzung: 10 ML/M3 MAK: 25 mg/m3 MAK: 10 ML/M3 Arbejdstilsynet (Denmark, 1996). GV: 25 mg/m3 GV: 10 ppm Tyterveyslaitos (Finland, 1998). STEL: 37 mg/m3 STEL: 15 ppm TWA: 25 mg/m3 TWA: 10 ppm EH40-OES (United Kingdom (UK), 2000). STEL: 37 mg/m3 STEL: 15 ppm TWA: 25 mg/m3 TWA: 10 ppm NAOSH (Ireland, 1999). STEL: 37 mg/m3 STEL: 15 ppm OEL: 25 mg/m3 OEL: 10 ppm JSOH (Japan, 1996). TWA: 25 mg/m3 TWA: 10 ppm Ministry of Labour (KR, 1997). STEL: 37 mg/m3 STEL: 15 ppm TWA: 25 mg/m3 TWA: 10 ppm Secretary of Work and Social security (MX, 1994). CCT: 37 mg/m3 Period: 15 minute(s). Continued on Next Page Gomori Trichrome Stain 623 Page: 5/8 CCT: 15 ppm Period: 15 minute(s). CPT: 25 mg/m3 Period: 8 hour(s). CPT: 10 ppm Period: 8 hour(s). Nationale MAC-lijst (Netherlands, 2000). TGG 8 uur: 25 mg/m3 TGG 8 uur: 10 ppm Arbeidstilsynet (Norway, 1996). AN: 25 mg/m3 AN: 10 ppm NZ OSH (NZ, 1994). STEL: 37 mg/m3 STEL: 15 ppm TWA: 25 mg/m3 TWA: 10 ppm AFS (Sweden, 1996). TGV: 25 mg/m3 TGV: 10 ppm NGV: 13 mg/m3 NGV: 5 ppm ACGIH TLV (United States, 2000). STEL: 37 mg/m3 STEL: 15 ppm TWA: 25 mg/m3 TWA: 10 ppm Fast Green FCF Not available. Phosphotungstic Acid Not available. Water Not available. The lowest known value is 99.9°C (211.8°F) (Water). Weighted average: 100.08°C (212.1°F) Liquid. Acidic. May start to solidify at 16.72°C (62.1°F) based on data for: Acetic acid.. Weighted average: 0.07°C (32.1°F) The only known value is 1.051 (Water = 1) (Acetic acid.). The highest known value is 2.1 (Air = 1) (Acetic acid.). Not available. Not available. Soluble in water. Not available. Not applicable. Nearly Odorless Dark Green or Maroon solution Boiling/Condensation Point Melting/Freezing Point The highest known value is 1.34 (Acetic Acid) Weighted average: 0.37compared to(n-Butyl Acetate =1) Section 9. Physical and Chemical Properties Physical State and Appearance Molecular Weight pH Specific Gravity Vapor Pressure Vapor Density Odor Threshold Evaporation Rate LogKow Solubility Odor Color Molecular Formula Not applicable. Continued on Next Page Gomori Trichrome Stain 623 Page: 6/8 The product is stable. Highly reactive with oxidizing agents. Will not occur. NOx , SOx Hygroscopic; keep container tightly closed.(Fast Green FCF) Section 10. Stability and Reactivity Stability and Reactivity Conditions of Instability Incompatibility with Various Substances Hazardous Decomposition Products Hazardous Polymerization Rem/Incompatibility Extreme heat Acute oral toxicity (LD50): 3310 mg/kg [Rat]. (Acetic acid.). Not available. Material is irritating to mucous membranes and upper respiratory tract. Section 11. Toxicological Information Toxicity Chronic Effects on Humans Special Remarks on Other Toxic Effects on Humans Acute Effects on Humans Hazardous in case of eye contact (irritant). Inflammation of the eye is characterized by redness, watering, and itching. Hazardous in case of skin contact (permeator, irritant). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Hazardous in case of inhalation (lung irritant). Hazardous in case of ingestion. Synergetic Products (Toxicologically) Not available. Irritancy Draize Test: Not available. Sensitization Not available. Carcinogenic Effects Classified 3 by IARC(Fast Green FCF) Toxicity to Reproductive System Not available. Teratogenic Effects Not available. Mutagenic Effects Not available. RTECS Number: Chromotrope 2R QJ6418000 Acetic Acid AF1225000 Fast Green FCF BQ4425000 Phosphotungstic Acid Not available. Water ZC0110000 Not available. Not available. The products of degradation are less toxic than the product itself. Section 12. Ecological Information Ecotoxicity BOD5 and COD Toxicity of the Products of Biodegradation Continued on Next Page Gomori Trichrome Stain 623 Page: 7/8 D002 Specified Technology - Neutralize to pH 6-9. Contact your local permitted waste disposal site (TSD) for permissible treatment sites. ALWAYS CONTACT PERMITTED WASTE DISPOSER (TSD) TO ASSURE COMPLIANCE WITH ALL CURRENT LOCAL, STATE AND FEDERAL REGULATIONS. EPA Waste Number Treatment Section 13. Disposal Considerations Section 14. Transport Information DOT Classification TDG Classification IMO/IMDG Classification ICAO/IATA Classification Not available. Not available. Not available. Not available. U.S. Federal Regulations Section 15. Regulatory Information TSCA 8(b) inventory: Acetic Acid; Fast Green FCF; Phosphotungstic Acid; Water Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: Acetic acid. Clean air act (CAA) 112 accidental release prevention: No products were found. Clean air act (CAA) 112 regulated flammable substances: No products were found. Clean air act (CAA) 112 regulated toxic substances: No products were found. CEPA DSL: Acetic Acid; Fast Green FCF; Water Australia (NICNAS): Chromotrope 2R; Acetic acid.; Fast Green FCF; Phosphotungstic Acid; Water China: Fast Green FCF Germany water class: Acetic acid. Japan (MITI): Acetic acid.; Phosphotungstic Acid; Water Korea (TCCL): Acetic acid.; Water WHMIS (Canada) Class D-2A: Material causing other toxic effects (VERY TOXIC). DSCL (EEC) R36/38- Irritating to eyes and skin. International Regulations Chromotrope 2R 224-085-0 Acetic Acid 200-580-7 Fast Green FCF 219-091-5 Phosphotungstic Acid Not available. Water 231-791-2 EINECS International Lists SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: Acetic Acid; Fast Green FCF SARA 311/312 MSDS distribution - chemical inventory - hazard identification: Acetic Acid: Fire Hazard, Immediate (Acute) Health Hazard, Delayed (Chronic) Health Hazard; Fast Green FCF: Delayed (Chronic) Health Hazard SARA 313 toxic chemical notification and release reporting: No products were found. + This product has been classifed in accordance with the hazard criteria of the Controlled Product Regulations and the MSDS contains all required information. Continued on Next Page Gomori Trichrome Stain 623 Page: 8/8 Pennsylvania RTK: Acetic acid.: (environmental hazard, generic environmental hazard) Massachusetts RTK: Acetic acid. New Jersey: Gomori Trichrome Stain California prop. 65: No products were found. State Regulations Philippines (RA6969): Acetic acid.; Fast Green FCF; Water China: Fast Green FCF + Section 16. Other Information Notice to Reader The statements contained herein are based upon technical data that EMD Chemicals Inc. believes to be reliable, are offered for information purposes only and as a guide to the appropriate precautionary and emergency handling of the material by a properly trained person having the necessary technical skills. Users should consider these data only as a supplement to other information gathered by them and must make independent determinations of suitability and completeness of information from all sources to assure proper use, storage and disposal of these materials and the safety and health of employees and customers and the protection of the environment. EMD CHEMICALS INC. MAKES NO REPRESENTATION OR WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE, WITH RESPECT TO THE INFORMATION HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. 0 0 1 National Fire Protection Association (U.S.A.) Health Specific Hazard Reactivity Fire Hazard Changed Since Last Revision