======================================================= MSDS Safety Information ======================================================= NAME: HEMATOXYLIN, RICHARD-ALLAN ======================================================= Material Safety Data Sheet 60290 Print Date: 2/26/07 Revision Date: 10/20/2006 ACC# Hematoxylin, certified Version: 8 Section 1 - Chemical Product and Company Identification MSDS Name: Hematoxylin, certified Catalog Numbers: 90022 Synonyms: Benz (B) Indol (1,2-D) Pyran-3,4,6A,9,10 (6H)-Pentol,7,11B-Dihydro, Cis-(+)-; Hematoxiline; Hydroxybrazilin; Hydroxybrasilin; Natural Black I. Company Identification: Richard Allan Scientific 4481 Campus Drive Kalamazoo, MI 49008 Company Phone Number: 800-522-7270 Emergency Phone Number: 800-424-9300 CHEMTREC Phone Number, US: (800) 424-9300 CHEMTREC Phone Number, Europe: (202) 483-7616 Section 2 - Composition, Information on Ingredients Percent EINECS/ CAS# Chemical Name: ELINCS 517-28-2 Hematoxylin 100 208-237-3 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: White to yellow crystals Caution! May cause eye, skin, and respiratory tract irritation. Light sensitive. The toxicological properties of this material have not been fully investigated. Target Organs: None known Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Page 1 Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Chronic: No information found. Section 4 - First Aid Measures Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. Section 5 - Fire Fighting Measures General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or appropriate foam. Autoignition Temperature: Not applicable. Explosion Limits: Lower: Not available Upper: Not available Flash Point: Not applicable. NFPA Rating: (estimated) Health: 1; Flammability: 0; Instability: 0 Page 2 Material Safety Data Sheet 60290 Print Date: 2/26/07 Revision Date: 10/20/2006 ACC# Hematoxylin, certified Version: 8 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions. Provide ventilation. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits Chemical Name: ACGIH NIOSH OSHA Hematoxylin None listed None listed None listed OSHA Vacated PELs Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Page 3 Material Safety Data Sheet 60290 Print Date: 2/26/07 Revision Date: 10/20/2006 ACC# Hematoxylin, certified Version: 8 Section 9 - Physical and Chemical Properties Physical State: Crystals Color: White to yellow Odor: No information found pH: No information found Vapor Pressure: Negligible. Vapor Density: No information found Evaporation Rate: Negligible. Viscosity: No information found Boiling Point: No information found Freezing/Melting Point: 100 - 120°C Decomposition Temperature: No information found Solubility in water: Soluble in hot water. Specific Gravity/Density: No information found Molecular Formula: C16H14O6 Molecular Weight: 302.27 Section 10 - Stability and Reactivity Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Turns reddish-brown on exposure to light. Conditions to Avoid: Incompatible materials, light, dust generation, excess heat Incompatibilities with Other Materials Strong oxidizing agents Hazardous Decomposition Products Carbon monoxide, carbon dioxide, hydrocarbons Hazardous Polymerization Has not been reported Section 11 - Toxicological Information RTECS: CAS# 517-28-2: MH7875000 LD50/LC50: CAS# 517-28-2: No information found Carcinogenicity: CAS# 517-28-2: Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. Page 4 Material Safety Data Sheet 60290 Print Date: 2/26/07 Revision Date: 10/20/2006 ACC# Hematoxylin, certified Version: 8 Epidemiology: No information found Teratogenicity: No information found Reproductive: No information found Mutagenicity: No information found Neurotoxicity: No information found Other: See actual entry in RTECS for complete information. Section 12 - Ecological Information No information found Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Part 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P Series Wastes None of the components are on this list. RCRA U Series Wastes None of the components are on this list. Section 14 - Transport Information US DOT Canadian TDG Proper Shipping Name: Not Regulated Not Regulated Hazard Class: UN Number: Packing Group: Section 15 - Regulatory Information US Federal TSCA CAS# 517-28-2 is listed on the TSCA Inventory. Page 5 Material Safety Data Sheet 60290 Print Date: 2/26/07 Revision Date: 10/20/2006 ACC# Hematoxylin, certified Version: 8 Health and Safety Reporting List None of the components are on this list. Chemical Test Rules None of the components are on this list. TSCA Section 12b None of the components are on this list. TSCA Significant New Use Rule (SNUR) None of the components are on this list. CERCLA Hazardous Substances and corresponding RQs None of the components are on this list. SARA Section 302 Extremely Hazardous Substances None of the components are on this list. SARA Hazard Categories Not available SARA Section 313 None of the components are on this list. Clean Air Act - Hazardous Air Pollutants (HAPs) None of the components are on this list. Clean Air Act - Class 1 Ozone Depletors None of the components are on this list. Clean Air Act - Class 2 Ozone Depletors None of the components are on this list. Clean Water Act - Hazardous Substances None of the components are on this list. Clean Water Act - Priority Pollutants None of the components are on this list. Clean Water Act - Toxic Pollutants None of the components are on this list. OSHA - Highly Hazardous None of the components are on this list. OSHA - Specifically Regulated Chemicals None of the components are on this list. US State State Right to Know No information found California Prop 65 None of the components are on this list. California No Significant Risk Level None of the components are on this list. European/International Regulations Page 6 Material Safety Data Sheet 60290 Print Date: 2/26/07 Revision Date: 10/20/2006 ACC# Hematoxylin, certified Version: 8 European Labelling in Accordance with EC Directives: Hazard Symbols: None listed Risk Phrases: None listed Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) No information found United Kingdom Occupational Exposure Limits No information found United Kingdom Maximum Exposure Limits No information found Canadian DSL/NDSL CAS# 517-28-2 is listed on Canada's DSL List. Canadian WHMIS Classifications This product has a WHMIS classification of D2B. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List No information found Section 16 - Other Information No information found MSDS Creation Date: May 7, 1998 Revision Date: October 20, 2006 Revisions were made in Sections: 3, 5, 10, 11, 14, 15 This MSDS is intended for review and guidance in the receipt, storage, handling, use and disposal of product purchased from us, and for no other purpose. Use this product only as directed and in accordance with applicable instructions and warnings provided with the product. Please consult your institution's policies regarding use of this product. If you have obtained this MSDS other than in connection with the supply of this product from us, this MSDS should be consulted for general information only, and should not be relied upon for any purpose. As with the use of all hazardous materials, you should in all instances follow the guidance of the MSDS provided or available with the specific product purchased. Page 7 Material Safety Data Sheet 60290 Print Date: 2/26/07 Revision Date: 10/20/2006 ACC# Hematoxylin, certified Version: 8