113 Hartwell Ave., Lexington, MA 02421
CO 407170 Sheet 1 of 5 Part No. 190836-47 Rev 06
Eff. Date: 09/08/2008
Emergency Number: Chemtrec @ 1-800-424-9300
1. IDENTIFICATION OF PRODUCT
This Material Safety Data Sheet applies to:
Product Name Part No.
HemosIL SynthASil 0020006800
• APTT Reagent
• Calcium Chloride
2. COMPOSITION (Based on Calcium Chloride formulation with sodium azide)
INGREDIENT NAME CONCENTRATION
PERCENT BY WEIGHT
APTT Reagent
-Tektamer 38 LV (preservative)
Chemical Name:
1,2 Dibromo-2,4 diacyanobutane (DBDCB)
CAS No.:35691-65-7
Hazard Classification: Xn (as raw material)
Risk Code: R20/21/22
R20/21/22: Harmful by inhalation, in
contact with skin or if swallowed
< 0.1
Calcium Chloride
-Calcium Chloride Dehydrate
CAS No.: 10035-04-8
0.29
EINECS No.: 233-140-8
Hazard Classification: Xi (as raw material)
Risk Code: R36: irritating to eyes
- Sodium Azide (preservative)
CAS No.: 26628-22-8
< 0.1
EINECS No.: 247-852-1
Hazard Classification: T+ (as raw material)
Risk Code: R28-32
R28: very toxic if swallowed
R32: contact with acid liberates very
toxic gas
MATERIAL SAFETY
DATA SHEET
113 Hartwell Ave., Lexington, MA 02421
CO 407170 Sheet 2 of 5 Part No. 190836-47 Rev 06
Eff. Date: 09/08/2008
3. HAZARD IDENTIFICATION
POTENTIAL HEALTH EFFECTS
EYES
Direct eye contact may cause redness and irritation.
SKIN
Prolonged or repeated contact may cause skin irritation.
INGESTION
Harmful if swallowed.
INHALATION
Mild irritant
4. FIRST AID MEASURES
EYES
In case of eye contact, flush eyes with plenty of water for at least 15 minutes. Ensure adequate flushing by separating the eyelids
with fingers. Obtain medical attention if irritation develops.
SKIN
Promptly wash exposed areas thoroughly with soap and water. Obtain medical attention if irritation develops.
INGESTION
Rinse mouth with plenty of water. Obtain medical attention or contact the local Poison Control Center.
INHALATION
Remove individual to fresh air. Obtain medical attention if breathing becomes difficult.
5. FIRE FIGHTING MEASURES
FLAMMABLE PROPERTIES
FLASH POINT: Not Applicable
LOWER EXPLOSIVE LIMIT (%): Not Applicable
UPPER EXPLOSIVE LIMIT (%): Not Applicable
FIRE AND EXPLOSION HAZARDS
Not Applicable
EXTINGUISHING MEDIA
Use any extinguishing agent that is suitable for the surrounding fire.
FIRE FIGHTING INSTRUCTIONS
Wear self-contained breathing apparatus and protective clothing that is appropriate for fighting a typical fire involving chemical
materials.
6. ACCIDENTAL RELEASE MEASURES
Wear appropriate personal protective equipment as specified in Section 8.
Clean up spills in a manner that does not disperse dust into the air or create aerosols of prepared solutions. Dry spills should be
moistened with water or an EPA approved disinfectant. Contain spill and decontaminate the area. Pick up material and dispose
in biohazard/sharps container as appropriate.
113 Hartwell Ave., Lexington, MA 02421
CO 407170 Sheet 3 of 5 Part No. 190836-47 Rev 06
Eff. Date: 09/08/2008
7. HANDLING AND STORAGE
HANDLING AND STORAGE PRECAUTIONS
Avoid contact with skin and eyes.
Reference the product labeling for handling and storage instructions.
Calcium Chloride Special Requirements: keep away from acids (sodium azide reacts strongly) and away from contamination
with heavy metals. Sodium azide has been reported to form lead or copper azide in laboratory plumbing which may explode on
percussion. Do not empty into drains.
WORK/HYGIENIC PRACTICES
Use good hygienic practices. Wash hands with soap and water after use.
8. EXPOSURE CONTROLS/PERSONAL PROTECTION
ENGINEERING CONTROLS
None normally required.
EYE/FACE PROTECTION
Safety glasses or splash goggles are recommended.
SKIN PROTECTION
Wear protective (latex/non-latex) gloves and laboratory coat as required to prevent skin contact.
RESPIRATORY PROTECTION
None normally required with adequate ventilation.
OTHER/GENERAL PROTECTION
None normally required.
9. PHYSICAL AND CHEMICAL PROPERTIES
APTT Reagent Calcium Chloride
Appearance: liquid liquid
Color clear to slightly cloudy colorless
Odor: odorless odorless
Density: Not Determined Not Determined
pH: 7.25 at 25ºC Not Determined
BASIC PHYSICAL PROPERTIES
VAPOR PRESSURE: Not determined
SPECIFIC GRAVITY: Not determined
SOLUBILITY (H20): Complete
10. STABILITY AND REACTIVITY
STABILITY: Stable
INCOMPATIBLE MATERIALS:
Strong Acids (See Section 7)
HAZARDOUS DECOMPOSITION PRODUCTS:
Harmful fumes of CO, CO2, NOx and Na2O may be formed during thermal decomposition.
HAZARDOUS POLYMERIZATION: Will not occur.
113 Hartwell Ave., Lexington, MA 02421
CO 407170 Sheet 4 of 5 Part No. 190836-47 Rev 06
Eff. Date: 09/08/2008
11. TOXICOLOGICAL INFORMATION
MISCELLANEOUS TOXICOLOGICAL INFORMATION
Carcinogenicity: NTP: no IARC: no OSHA: :no
- Tektamer 38 LV orl-rat LD50 : 1.7 g/kg (similar product manufacture’s data)
(DBDCB) skin-rabbit LD50: > 8g/kg (similar product manufacture’s data)
inhalation-rat LC50: < 338 mg/L (similar product manufacture’s data)
Reproductive effects data and references:
orl-rat TD low 1750 mg/kg (6-15 d preg.) (NIOSH)
- Sodium azide: orl-rat LD50: 27 mg/kg; skn-rbt LD50: 20 mg/kg; TLV CEILING 0.11 ppm (0.3 mg/m3).
OSHA PEL Final-CL: 0.1 ppm (HN3) (skin); OSHA PEL Final-CL: 0.3 mg (NaN3)/m³ (skin).
Experimental mutagenic and tumorogenic data (NIOSH).
-Calcium Chloride: ipr-mus LD50: 20500 mg/kg: orl-rat LD50: 1000 mg/kg (anhydrous form); mutagenic and tumorogenic data
(anhydrous form) (NIOSH.
The health effects noted above are based on the extrapolation of data on the pure product ingredients. To the best of our
knowledge, no health effects have been identified for the product mixture under normal conditions of use, although the health
effects of the product have not been thoroughly investigated.
MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE
None known
12. ECOLOGICAL INFORMATION
OTHER ENVIRONMENTAL INFORMATION
No ecotoxicological data are available on the product.
Tektamer 38 LV: effect toxic to fish: LC50 (bluegill sun fish) 4.09 ppm (96 hrs)
(DBDCB) LC50 (daphnia magna) 2.2 ppm (48 hrs)
LC50 (rainbow trout) 1.75 ppm (96 hrs)
Calcium Chloride dry: effect toxic to fish (5100 mg/L) and crustacean (990 mg/L)
Sodium Azide: effect toxic to fish (0.98 -8 mg/L) and plankton (5-14 mg/L).
Use in accordance with good laboratory practice. Do not waste in the environment.
13. DISPOSAL CONSIDERATIONS
The product waste is classified as toxic and harmful (azides). Dispose of waste product, unused product and contaminated
packaging in compliance with federal, state and local regulations. If unsure of the applicable requirements, contact the
authorities for information. It is up to the user to classify the waste correctly prior to disposal.
14. TRANSPORT INFORMATION
Not regulated.
113 Hartwell Ave., Lexington, MA 02421
CO 407170 Sheet 5 of 5 Part No. 190836-47 Rev 06
Eff. Date: 09/08/2008
15. REGULATORY INFORMATION
This product is classified and labeled in accordance with Directive 1999/45/EC and following modifications. The health hazard
classification has been determined based on composition and hazard data of each ingredient. Physical and health hazard
information on the reagent mixture has not been determined. Any physical and health hazard information noted is based on a)
evaluation of data of the pure ingredient and b) concentration of each ingredient.
KIT HAZARD CLASSIFICATION
- Symbol: Not applicable
- Risk Code: Not applicable
- Safety Code: S24/25 - 29 - 36
S24/25: avoid contact with skin and eyes
S29: do not empty into drains
S36: wear suitable protective clothing
16. OTHER INFORMATION
REFERENCE DOCUMENTATION
Primary references used in the preparation of this document
1. Product Specification.
2. Product Insert.
NOTE
The information supplied in this Material Safety Data Sheet represents the data and best information available at the date of
preparation. It is provided with the aim of allowing proper and safe use, storage, transport and disposal of the product. It is not
to be considered as a warranty or specification of product quality. It is related to the materials specifically indicated and does
not apply if these are used in combination with other materials or during processes not specifically indicated in the text of this
Material Safety Data Sheet.