HEPARIN, Na HEPARIN, Na MSDS Number: H0314 --- Effective Date: 05/08/00 1. Product Identification Synonyms: Sodium heparin; Heparin, sodium salt; sodium acid heparin; sodium heparinate CAS No.: 9041-08-1 Molecular Weight: ca. 12000 Chemical Formula: ca. (C12H16NS2Na3)20 Product Codes: M916 2. Composition/Information on Ingredients Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------- --------- Sodium Heparin 9041-08-1 98 - 100% Yes 3. Hazards Identification Emergency Overview -------------------------- WARNING! MAY BE HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. Potential Health Effects ---------------------------------- Information on the human health effects from exposure to this substance is limited. Inhalation: No information found, but compound should be handled as a potential health hazard. May cause irritation to the respiratory tract. Symptoms may include coughing, sore throat, labored breathing, and chest pain. Ingestion: No information found, but compound should be handled as a potential health hazard. May cause irritation to the gastrointestinal tract. Symptoms may include nausea, vomiting and diarrhea. Skin Contact: No information found, but compound should be handled as a potential health hazard. May cause irritation with redness and pain. May be absorbed through the skin with possible systemic effects. Eye Contact: No information found, but compound should be handled as a potential health hazard. May cause irritation, redness and pain. Chronic Exposure: No information found. Aggravation of Pre-existing Conditions: No information found. 4. First Aid Measures Inhalation: Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Ingestion: Give large amounts of water to drink. Never give anything by mouth to an unconscious person. Get medical attention. Skin Contact: Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention if symptoms occur. Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Get medical attention if irritation persists. 5. Fire Fighting Measures Fire: As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source. Explosion: Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. Fire Extinguishing Media: Water spray, dry chemical, alcohol foam, or carbon dioxide. Special Information: In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode. 6. Accidental Release Measures Remove all sources of ignition. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Spills: Clean up spills in a manner that does not disperse dust into the air. Use non-sparking tools and equipment. Reduce airborne dust and prevent scattering by moistening with water. Pick up spill for recovery or disposal and place in a closed container. 7. Handling and Storage Keep in a tightly closed container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from incompatible substances. Containers of this material may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product. 8. Exposure Controls/Personal Protection Airborne Exposure Limits: None established. Ventilation System: A system of local and/or general exhaust is recommended to keep employee exposures as low as possible. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details. Personal Respirators (NIOSH Approved): For conditions of use where exposure to the dust or mist is apparent, a half-face dust/mist respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator. WARNING: Air-purifying respirators do not protect workers in oxygen-deficient atmospheres. Skin Protection: Wear protective gloves and clean body-covering clothing. Eye Protection: Use chemical safety goggles. Maintain eye wash fountain and quick-drench facilities in work area. Other Control Measures: There is insufficient data in the published literature to assign complete numerical SAF-T-DATA* ratings and laboratory protective equipment for this product. Special precautions must be used in storage, use and handling. Protective equipment for laboratory bench use should be chosen using professional judgment based on the size and type of reaction or test to be conducted and the available ventilation, with overriding consideration to minimize contact with the chemical. 9. Physical and Chemical Properties Appearance: White powder. Odor: Odorless. Solubility: Soluble in water. Specific Gravity: No information found. pH: 6.0-7.5 (1% aqueous solution) % Volatiles by volume @ 21C (70F): 0 Boiling Point: No information found. Melting Point: No information found. Vapor Density (Air=1): No information found. Vapor Pressure (mm Hg): 0 @ 20C (68F) Evaporation Rate (BuAc=1): 0 10. Stability and Reactivity Stability: Stable under ordinary conditions of use and storage. Hygroscopic. Hazardous Decomposition Products: Burning may produce carbon monoxide, carbon dioxide, sulfur oxides, and nitrogen oxides. Hazardous Polymerization: Will not occur. Incompatibilities: Strong oxidizers. Conditions to Avoid: Heat, flames, ignition sources and incompatibles. 11. Toxicological Information Oral rat LD50: > 6 gm/kg. Investigated as a reproductive effector. --------\Cancer Lists\------------------------------------------------------ ---NTP Carcinogen--- Ingredient Known Anticipated IARC Category ------------------------------------ ----- ----------- ------------- Sodium Heparin (9041-08-1) No No None 12. Ecological Information Environmental Fate: No information found. Environmental Toxicity: No information found. 13. Disposal Considerations Whatever cannot be saved for recovery or recycling should be managed in an appropriate and approved waste disposal facility. Processing, use or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state and local requirements. 14. Transport Information Not regulated. 15. Regulatory Information --------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Sodium Heparin (9041-08-1) Yes No No Yes --------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil. ----------------------------------------------- ----- --- ---- ----- Sodium Heparin (9041-08-1) No Yes No No --------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg. ----------------------------------------- --- ----- ---- -------------- Sodium Heparin (9041-08-1) No No No No --------\Federal, State & International Regulations - Part 2\---------------- -RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ----------------------------------------- ------ ------ ------ Sodium Heparin (9041-08-1) No No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: No SARA 311/312: Acute: Yes Chronic: No Fire: No Pressure: No Reactivity: No (Pure / Solid) Australian Hazchem Code: No information found. Poison Schedule: No information found. WHMIS: This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and the MSDS contains all of the information required by the CPR. 16. Other Information NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0 Label Hazard Warning: WARNING! MAY BE HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. Label Precautions: No SAF-T-DATA Ratings have been developed for this product. Read and follow all warnings, precautions, instructions and other safety and handling information on the label and MSDS. Avoid breathing dust. Avoid contact with eyes, skin and clothing. Keep container closed. Use with adequate ventilation. Wash thoroughly after handling. Label First Aid: In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, give large amounts of water to drink. Never give anything by mouth to an unconscious person. In all cases, get medical attention. Product Use: Laboratory Reagent. Revision Information: New 16 section MSDS format, all sections have been revised. Disclaimer: ************************************************************************************************ Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. MALLINCKRODT BAKER, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, MALLINCKRODT BAKER, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION. ************************************************************************************************ Prepared by: Strategic Services Division Phone Number: (314) 539-1600 (U.S.A.)