SIGMA-ALDRICH CHEMICAL CO -- KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAM ======================================================= MSDS Safety Information ======================================================= FSC: 6810 MSDS Date: 03/16/1999 MSDS Num: CJPJK LIIN: 00N091818 Product ID: KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETICUS, K4000 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA-ALDRICH CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Resp. Party Other MSDS No.: C18H36N4011 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Box: 14508 City: ST LOUIS MO 63178 Phone: 1-314-771-5765 ======================================================= Ingredients ======================================================= Cas: 25389-94-0 RTECS #: NZ3225030 Name: KANAMYCIN, SULFATE (1:1) (SALT); (MF:C*18H*36N*4O*11) ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: LD50:(ORAL,RAT) >4 GM/KG & TOX INFO Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALL ERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. AMINOGLYCOSIDES ARE ASSOCIATED WITH SIGNIFICANT NEPHROTOXICITY AND/OR OTOTOXICITY. CHRONIC: MAY CAUSE CONGENITAL MALFORMATION IN THE FETUS. TARGET ORGAN(S): KIDNEYS, EARS. TO THE BEST OF MFR 'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL MD. SKIN: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES REMOVE CONTAMINATED CLOTHING AND SHOES. CALL MD. INHALATION: REMOVE TO FRESH AIR. IF BREATHING BEC OMES DIFFICULT, CALL MD. EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING EYELIDS WITH FINGERS. CALL MD. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP TIGHTLY CLOSED. STORE IN A COOL, DRY PLACE. Other Precautions: TOXIC. MAY CAUSE HARM TO THE UNBORN CHILD. IN CASE OFACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW LABELWHERE POSSIBLE). ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES & FULL LENGTH FACESHIELD (FP N). Other Protective Equipment: ANSI APPROVED EYE WASH & DELUGE SHOWER (FP N). WEAR SUITABLE OTHER PROTECTIVE CLOTHING. Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. ======================================================= Physical/Chemical Properties ======================================================= Solubility in Water: SOLUBLE Appearance and Odor: SOLID. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Hazardous Decomposition Products: TOXIC FUMES OF: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES. Hazardous Polymerization Indicator: NO Conditions To Avoid Polymerization: WILL NOT OCCUR. ======================================================= Toxicological Information ======================================================= Toxicological Information: LD50:(ORAL,RAT) >4 GM/KG - JJANAX 28,415,1975; LD50:(IPR,RAT) 3200 MG/KG - JJANAX 28,415,1975; LD50:(SCU,RAT) 1700 MG/KG - ARZNAD 12,597,1962; LD50:(IVN,RAT) 225 MG/KG - JJANAX 28,415,1975; LD50:(IMS,RAT) >4 GM/KG - JJANAX 28,415,1975; LD5 0:(ORAL,MUS) 17,500 MG/KG - NIIRDN 6,173,1982; LD50:(IPR,MUS) 1353 MG/KG - AACHAX -,138,1963; LD50:(SCU,MUS) 1100 MG/KG - ANTBAL 29,851,1984; LD50:(IVN,MUS) 240 MG/KG - NIIRDN 6,173,1982; LD50:(IMS,MUS) 1190 MG/KG - NIIRDN 6,173,1982; LD50 :(ORAL,RBT) >3 GM/KG - JJANAX 28,415,1975; LD50:(SCU,RBT) >3 GM/KG - JJANAX 28,415,1975; LD50:(IVN,RBT) 550 MG/KG - JJANAX 28,415,1975; (OTHER INFO) ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: REVIEWS, STANDARDS AND REGULATIONS: OEL=MAK. NOES 1983; HZD X4729; NIS 2; TNF 320; NOS 6; TNE 11433; TFE 8118. EUROPEAN INFO: TOXIC; R61 MAY CAUSE HARM TO THE UNBORN CHILD, S45 IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MED ADVICE I MMED (SHOW LABE WHERE POSS), S36/37/39 WEAR SUITABLE PROT CLTHG, GLOVES, & EYE/FACE PROT. State Regulatory Information: CALIFORNIA PROPOSITION 65. THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE DEVELOPMENTAL TOXICITY. ======================================================= Other Information ======================================================= Other Information: MFR'S INFO: CUST #: 0-495-05107; PO #: CC/99C22490805; EC #: 246-933-9. -- TOX INFO: LD50:(IMS,RBT) >3 GM/KG - JJANAX 28,415,1975. TARGET ORGAN DATA: SENSE ORGANS AND SPECIAL SENSES (CHANGE IN ACUITY); BEHAVIORAL (CHANGE IN MOTOR ACTIVITY) ; LUNGS, THORAX OR RESPIRATION (OTHER CHANGES); EFFECTS TO EMBRYO OR FETUS (FETOTOXICITY, FETAL DEATH); SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM); NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATUE DECREASE). ONLY SELECTE D REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ======================================================= HAZCOM Label ======================================================= Product ID: KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETICUS, K4000 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 08/09/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Slight Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. AMINOGLYCOSIDES ARE ASSOCIATED WITH SIGNIFI CANT NEPHROTOXICITY AND/OR OTOTOXICITY. CHRONIC: MAY CAUSE CONGENITAL MALFORMATION IN THE FETUS. SKIN: PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. TARGET ORGAN(S): KIDNEYS, EARS. TO THE BES T OF MFR'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.