SIGMA CHEMICAL CO -- KANAMYCIN SULFATE USP, K1637 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 07/01/1999 MSDS Num: CJTZJ LIIN: 00N092466 Product ID: KANAMYCIN SULFATE USP, K1637 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST Box: 14508 City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Item Description Information ======================================================= ======================================================= Ingredients ======================================================= Cas: 25389-94-0 RTECS #: NZ3225030 Name: KANAMYCIN SULFATE ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: LD50 (ORAL,RAT): >4 GM/KG Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. P ROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. AMINOGLYCOSIDES ARE ASSOCIATED WITH SIGNIFICANT NEPHROTOXICITY AND/OR OTOTOXICITY CHRONIC: MAY CAUSE CONGEN ITAL MALFORMATION IN THE FETUS. TARGET ORGAN (S): KIDNEYS, EARS. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. SKIN: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES. CALL A P HYSICIAN. INHALATION: REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL A PHYSICIAN. EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING T HE EYELIDS WITH FINGERS. CALL A PHYSICIAN. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: USE NIOSH APPROVED SCBA & FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: CHEMICAL RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: EYE WASH AND DELUGE SHOWER MEETING ANSI DESIGN CRITERIA (FP N). Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. ======================================================= Physical/Chemical Properties ======================================================= Appearance and Odor: SOLID. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Hazardous Decomposition Products: HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS: TOXIC FUMES OF: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES. Hazardous Polymerization Indicator: NO Conditions To Avoid Polymerization: WILL NOT OCCUR. ======================================================= Toxicological Information ======================================================= Toxicological Information: TO THE BEST OF MFR'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, & TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. RTECS #: NZ3225030 KANAMYCIN, SULFATE (1:1) (SALT). TOXICITY DATA: ORL-RAT LD5 0:>4 GM/KG JJANAX 28,415,1975. IPR-RAT LD50:3200 MG/KG JJANAX 28,415,1975. SCU-RAT LD50:1700 MG/KG ARZNAD 12,597,1962. IVN-RAT LD50:225 MG/KG JJANAX 28,415,1975. IMS-RAT LD50:>4 GM/KG JJANAX 28,415,19 75. ORL-MUS LD50:17500 MG/KG NIIRDN 6,173,1982. IPR-MUS LD50:1353 MG/KG AACHAX -,138,1963. SCU-MUS LD50:1100 MG/KG ANTBAL 29,851,1984. IVN-MUS LD50:240 MG/KG NIIRDN 6173,1982. IMS-MUS LD50:1190 MG/KG NIIRDN 6,173,1982 (OTHER INFORMATION) ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: EUROPEAN INFORMATION: TOXIC R 61 MAY CAUSE HARM TO THE UNBORN CHILD. S 45 IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW THE LABEL WHERE POSSIBLE). S 36/37/39 WEAR SU ITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. REVIEWS, STANDARDS, AND REGULATIONS: OEL=MAK. NOES 1983: HZD X4729; NIS 2; TNF 320; NOS 6: TNE 11433; TFE 8118. State Regulatory Information: U S INFORMATION: CALIFORNIA PROPOSITION 65: THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE DEVELOPMENTAL TOXICITY. ======================================================= Other Information ======================================================= Other Information: TOX INFO: ORL-RBT LD50:>3 GM/KG JJANAX 28,415,1975. SCU-RBT LD50:>3 GM/KG JJANAX 28,415.1975. IVN-RBT LD50:550 MG/KG JJANAX 28,415,1975. IMS-RBT LD50:>3 GM/KG JJANAX 28,415,1975. TARGET ORG DATA: SENS E ORGS & SPECIAL SENSES (CHANGE IN ACUITY). BEHAVIORAL (CHANGE IN MOTOR ACTIVITY). LUNGS, THORAX/RESPIRATION (OTHER CHANGES). EFTS ON EMBRYO/FETUS (FETOTOXICITY). EFTS OF EMBRYO/FETUS (FETAL DEATH). S PECIFIC DEVELOPOMENTAL ABNORM (MUSCULOSKELETAL SYS). NUTRITIONAL & GROSS METABOLIC (BODY TEMP DECREASE). ONLY SELECTED REGISTRY OF TOX EFTS OF CHEM SUBSTANCES (RTES) DATA IS PRESENTED HERE. SEE ATUAL ENTRY IN RTECS FO RCOMPLETE INFO. ======================================================= HAZCOM Label ======================================================= Product ID: KANAMYCIN SULFATE USP, K1637 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 11/08/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Moderate Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. AMINOGLYCOSIDES ARE ASSOCIATED WITH SIGNIFICANT NEPHROTOXICITY AND/OR OTOTOXICITY. CHRONIC: PROLONGED OR REPEATED EXPOSURE MAY CAUSEALLERGIC REACTIONS IN CERTAIN SENSITIVE INDIVIDUALS. MAY CAUSE CONG ENITAL MALFORMATION IN THE FETUS. TARGET ORGAN (S): KIDNEYS, EARS. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.