SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 09/OCT/2003 
Date Updated: 06/APR/2002 
Version 1.0 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name L-CYCLOSERINE 
Product Number C1159 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
(S)-(-)-CYCLOSERINE, 97% 339-72-0 206-427-0 
Formula C3H6N2O2 
Molecular Weight 102.09 AMU 
Synonyms (-)-4-Amino-3-isossazolidone (Italian), 
L-4-Amino-3-isoxazolidinone, 
(S)-4-Amino-3-isoxazolidinone,L-Cycloserine, 
3-Isoxazolidinone, 4-amino-, (S)- (9CI), 
L-Oxamicina (Italian) 
3 - Hazards Identification 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If breathing becomes difficult, 
call a physician. 
AFTER SKIN CONTACT 
In case of skin contact, flush with copious amounts of water for 
at least 15 minutes. Remove contaminated clothing and shoes. 
Call a physician. 
AFTER EYE CONTACT 
In case of contact with eyes, flush with copious amounts of 
water for at least 15 minutes. Assure adequate flushing by 
separating the eyelids with fingers. Call a physician. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician. 
5 - Fire Fighting Measures 
EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam. 
SPECIAL RISKS 
Specific Hazard(s): Emits toxic fumes under fire conditions. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear protective equipment. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
STORAGE 
Store at -20°C 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Mechanical exhaust required. 
9 - Physical and Chemical Properties 
Appearance Color: White 
Form: Powder 
Property Value At Temperature or Pressure 
pH N/A 
BP/BP Range N/A 
MP/MP Range 145 °C 
Flash Point N/A 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
Partition Coefficient N/A 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. N/A 
Solvent Content N/A 
Water Content < 3 % 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility N/A 
10 - Stability and Reactivity 
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STABILITY 
Stable: Stable. 
Materials to Avoid: Acids, Strong oxidizing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Thermal decomposition may 
produce carbon monoxide, carbon dioxide, and nitrogen oxides. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: NY2976000 
ACUTE TOXICITY 
LD50 
Oral 
Mouse 
2492 mg/kg 
LD50 
Intraperitoneal 
Mouse 
1889 MG/KG 
LD50 
Intravenous 
Mouse 
1071 MG/KG 
ROUTE OF EXPOSURE 
Multiple Routes: May be harmful by inhalation, ingestion, or 
skin absorption. 
CONDITIONS AGGRAVATED BY EXPOSURE 
May cause nervous system disturbances. The toxicological 
properties have not been thoroughly investigated. 
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Dissolve or mix the material with a combustible solvent and burn 
in a chemical incinerator equipped with an afterburner and 
scrubber. Observe all federal, state, and local environmental 
regulations. 
14 - Transport Information 
RID/ADR 
Non-hazardous for road transport. 
IMDG 
Non-hazardous for sea transport. 
IATA 
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Non-hazardous for air transport. 
15 - Regulatory Information 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
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