SIGMA CHEMICAL CO -- L-LEUCINE, L8000 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 07/01/1999 MSDS Num: CJVSV LIIN: 00N092457 Product ID: L-LEUCINE, L8000 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST Box: 14508 City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Item Description Information ======================================================= ======================================================= Ingredients ======================================================= Cas: 61-90-5 RTECS #: OH2850000 Name: L-LEUCINE ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE TOXICOLOGICAL INFO Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE EFFECTS: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRA CT. TO THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ADDITIONAL INFORMATION: THE LEVOROTARY (L) FORM OF LEUCINE, ISOL EUCINE AND VALINE HAVE BEEN FOUND TO HAVE TUMOR-PROMOTING ACTIVITY FOR BLADDER CARCINOMAS. SCIENCE 231, 843, 21 FEBRUARY 1986. ALSO, SEE TOXICOLOGICAL INFORMATION. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: EYES: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IN CASE OF CONTACT, IMMEDIATELY FLUSH SKIN WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 M INUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. INHALATION: IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. DISCARD CONTAMINATED CLOTHING AND SHOES. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED. VENTILATE AREA AND WAS H SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULAITONS. Handling And Storage Precautions: KEEP TIGHTLY CLOSED. STORE IN A COOL, DRY PLACE. Other Precautions: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. WASH THOROUGHLY AFTER HANDLING. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N) TO PREVENT CONTACT WITH SKIN AND EYES. Unusual Fire/Explosion Hazard: THIS MATERIAL, LIKE MOST MATERIALS IN POWDER FORM, IS CAPABLE OF CREATING A DUST EXPLOSION. EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EYE WASH AND DELUGE SHOWER (FP N). OTHER PROTECTIVE CLOTHING. ======================================================= Physical/Chemical Properties ======================================================= Melt/Freeze Pt: >300.C, 572.F Appearance and Odor: WHITE POWDER. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: TOXIC FUMES OF: CARBON MONOXIDE, CARBON DIOXIDE. NITROGEN OXIDES. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: RTECS #: OH2850000 LEUCINE, L-. TOXICITY DATA: IPR-RAT LD50: 5379 MG/KG ABBIA4 58,253,1955. TARGET ORGAN DATA: EFFECTS OF FERTILITY (POST-IMPLANTATION MORTALITY). EFFECTS ON EMBRYO OR FETUS (FETOTOXIC ITY). SPECIFIC DEVELOPMENTAL ABNORMALITIES (CENTRAL NERVOUS SYSTEM). SPECIFIC DEVELOPMENTAL ABNORMALITIES (EYE, EAR). SPECIFIC DEVELOPMENTAL ABNORMALITIES (CRANIOFACIAL). SPECIFIC DEVELOPMENTAL ABNORM ALITIES (BODY WALL). SPECIFIC DEVELOPMENTAL ABNORMALITIES (MUSCULOSKELETAL SYSTEM). SPECIFIC DEVELOPMENTAL ABNORMALITIES (UROGENITAL SYSTEM). SPECIFIC DEVELOPMENTAL ABNORMALITIES (OTHER INFO) ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: REVIEWS, STANDARDS, AND REGULATIONS: OEL=MAK. OEL-RUSSIA: STEL 5 MG/M3 JAN 1993. NOHS 1974: HZD 81818; NIS 1; TNF 53; NOS 3; TNE 750. NOES 1983: HZD 81818; NIS 4; TNF 1037; NOS 18; TNE 21979; TFE 1615 3. EPA TSCA SECTION 8(B) CHEMICAL INVENTORY. ======================================================= Other Information ======================================================= Other Information: HAZARDS IDENTIFICATION: DATA NOT AVAILABLE. ======================================================= HAZCOM Label ======================================================= Product ID: L-LEUCINE, L8000 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 12/07/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: CAUTION Respiratory Protection IND: YES Health Hazard: Slight Contact Hazard: Slight Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE EFFECTS: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRA CT. CHRONIC: THE LEVOROTARY (L) FORM OF LEUCINE, ISOLEUCINE AND VALINE HAVE BEEN FOUND TO HAVE TUMOR-PROMOTING ACTIVITY FOR BLADDER CARCINOMAS. POSSIBLE DEVELOPMENTAL EFFECTS. TO THE BEST OF MANUF ACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.