SIGMA CHEMICAL CO -- L-METHIONINE, M9625 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 07/01/1999 MSDS Num: CJTVN LIIN: 00N092663 Product ID: L-METHIONINE, M9625 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Ingredients ======================================================= Cas: 63-68-3 RTECS #: PD0457000 Name: METHIONINE, L-; (L-METHIONINE). LD50:(ORAL,RAT) 36 GM/KG. Percent by Wt: 100. ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE INGREDIENTS & TOXICOLOGICAL INFO. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER. INHALATION: REMOVE TO FRESH AIR. INGESTION: CALL MD IMMEDI ATELY (FP N). ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED. VENTILATE AREA AND WAS H SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN AND CLOTHING. AVOID PROLONGED AND REPEATED EXPOSURE. KEEP TIGHTLY CLOSED. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). ======================================================= Control Measures ======================================================= Respiratory Protection: NIOSH APPROVED RESPIRATOR APPROPRIATE FOR EXPOSURE OF CONCERN (FP N). Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: COMPATIBLE CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EYE WASH & DELUGE SHOWER (FP N). Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. Supplemental Safety and Health: MFR'S INFORMATION OF INGREDIENTS: MOLECULAR FORMULA: C5H11NO2S. EC NO: 200-562-9. ======================================================= Physical/Chemical Properties ======================================================= Melt/Freeze Pt: =284.C, 543.2F M.P/F.P Text: DECOMPOSES Decomp Temp: =284.C, 543.2F Appearance and Odor: WHITE CRYSTALS. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES, SULFUR OXIDES. Hazardous Polymerization Indicator: NO Conditions To Avoid Polymerization: WILL NOT OCCUR. ======================================================= Toxicological Information ======================================================= Toxicological Information: TO THE BEST OF MFR'S KNOWLEDGE, THE CHEMICAL, PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. TOXICITY DATA: LD50:(ORAL,RAT) 36 GM/KG - GISAAA 48(6),20,1983. LD50:(IPR,RAT ) 4328 MG/KG - ABBIA4 58,253,1955. LD50:(IPR,MUS) >9500 MG/KG - PMRSDJ 1,682,1981. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RT ECS FOR COMPLETE INFORMATION. ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: REVIEW, STANDARDS AND REGULATIONS: OEL= MAK. OEL-RUSSIA:STEL 5 MG/M3 JAN 1993. NOHS 1974: HZD 81891; NIS 5; TNF 23; NOS 17; TNE 12017 NOES 1983: HZD 81891; NIS 4; TNF 1116; NOS 18; TNE 28520; TFE 1703 8. EPA GENETOX PROGRAM 1988, NEGATIVE: SPERM MORPHOLOGY-MOUSE. EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS. EPA TSCA SECTION 8(B) CHEMICAL INVENTORY. EPA TSCA SECTION 8(D) UNPUBLISH ED HEALTH/SAFETY STUDIES. EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE. DECEMBER 1998 ======================================================= Other Information ======================================================= Other Information: HAZARDS IDENTIFICATION: DATA NOT AVAILABLE. ======================================================= HAZCOM Label ======================================================= Product ID: L-METHIONINE, M9625 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 11/24/1999 Status Code: A Origination Code: F Eye Protection IND: YES Skin Protection IND: YES Signal Word: CAUTION Respiratory Protection IND: YES Health Hazard: Slight Contact Hazard: Slight Fire Hazard: Slight Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. CHRO NIC: NONE LISTED BY MANUFACTURER. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.