SIGMA CHEMICAL CO -- L-TRYPTOPHAN, T0254 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 07/01/1999 MSDS Num: CJTTS LIIN: 00N092739 Product ID: L-TRYPTOPHAN, T0254 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Box: 14508 City: ST LOUIS MO 63178 Phone: 1-314-771-5765 ======================================================= Ingredients ======================================================= Cas: 73-22-3 RTECS #: YN6130000 Name: L-TRYPOTHAN ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: LD50 (ORAL, RAT): >16 GM/KG Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. THE FOOD AND DRUG ADMINISTRATION AND THE CENTER FOR DISEASE CONTROL HAVE ESTABLISHED A LINK BETWEEN L-TRYPTOPHAN AND A SOMETIME FATAL BLOOD DISORDER CALLED EOSINOPHILIA-MYALGIA SYNDROME WHICH IS MARKED BY SEVERE MUSCLE AND JOINT PAIN, SWELLING OF THE ARMS AND LEGS, SKIN RASH AND SOMETIMES FEVER. IT IS CHARACTERIZED BY SEVERE EOSINOPHILLIA, A BLOOD DISORDER IN WHICH THE WHITE BLOOD CELLS INCREASE TO AN ABNORMALLY HIGH LEVEL. L-TRYPTOPHAN OCURS NATURALLY IN MANY FOODS AND INVESTIGATION HAS NOT (EFTS OF OVEREXP) Signs And Symptions Of Overexposure: HLTH HAZ: ESTABLISHED WHETHER IT OR AN IMPURITY INTRODUCED DURING MANUFACTURE OR DISTRIBUTION IS THE CAUSE. First Aid: EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIF FICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILL MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: AVOID INHALATION. AVOID CONTACT WITH EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP TIGHTLY CLOSED. STORE IN COOL DRY PLACE. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: USE NIOSH APPROVED SCBA & FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: COMPATIBLE CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: EYE WASH AND DELUGE SHOWER MEETING ANSI DESIGN CRITERIA (FP N). Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. ======================================================= Physical/Chemical Properties ======================================================= Melt/Freeze Pt: >280.C, 536.F M.P/F.P Text: 280-285C Appearance and Odor: SOLID. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS TOXIC FUMES OF: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: RTECS #: YN6130000 TRYPTOPHAN, L- TOXICITY DATA: ORL-RAT LD50:>16 GM/KG IYKEDH 11,635,1980. IPR-RAT LD50:1634 MG/KG ABBIA4 58,253,1955. IPR-MUS LD50:4800 MG/KG IYKEDH 11,635,1980. IPR-BRD LD50:2410 MG/KG NIIRDN -, 744,1990. TARGET ORGAN DA TA: BEHAVIORAL (EXCITEMENT). BEHAVIORAL (ANTIANXIETY). LUNGS, THORAX/ RESP (DYSPNAE). KIDNEY, URETER, BLADDER (BLADDER TUMORS). BLOOD (EOSINOPHILIA). MUSCULO-SKELETAL (OTHER CHANGES). SKIN AND APPENDAGES (OTHER GLANDS). MATERNAL EFFECTS (O VARIES, FALLOPIAN TUBES). EFFECTS ON EMBRYO OR FETUS (MATERNAL-FETAL EXHANGE). EFFECTS ON NEWBORN (DELAYED EFFECTS). (OTHER INFO) ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: REVIEWS, STANDARDS, AND REGULATIONS: OEL=MAK. NOES 1983: HZD X3075; NIS 6; TNF 1257; NOS 19; TNE 24809; TFE 18622. EPA TSCA SECTION 8 (B) CHEMICAL INVENTORY. NCI CARCINOGENESIS BIOASSAY (FEED); NO EVIDENCE: MOUSE, RAT NCITR* NCI-TR-71,78. ======================================================= Other Information ======================================================= Other Information: TOXICOLOGICAL INFORMATION: NUTRITIONAL AND GROSS METABOLIC (BODY TEMPERATURE DECREASE). TUMORIGENIC (EQUIVOCAL TUMORIGENIC AGENT BY RTECS CRITERIA). ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED H ERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ======================================================= HAZCOM Label ======================================================= Product ID: L-TRYPTOPHAN, T0254 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 10/27/1999 Status Code: A Origination Code: F Eye Protection IND: YES Skin Protection IND: YES Signal Word: DANGER Respiratory Protection IND: YES Health Hazard: Severe Contact Hazard: Moderate Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHAL, INGEST/SKIN ABSORP. MAY CAUSE EYE & SKIN IRRIT. FOOD & DRUG ADMIN & THE CENTER FOR DISEASE CNTRL HAVE ESTABLISHED A LINK BETWEEN L-TRYPTOPHAN & SOMETIME FATAL BLOOD DISORDER CALLED EOSINOPHILIA-MYALGIA SYND ROME WHICH IS MARKED BY SEV MUSCLE & JOINT PAIN, SWELLING OF ARMS & LEGS, SKIN RASH & SOMETIMES FEVER. IT IS CHARACT BY SEV EOSINOPHILLIA, A BLOOD DISORDER IN WHICH THE WHITE BLOOD CELLS INCR TO AN ABNORM HIGH LEVEL. L-TRYPTOPHAN OCCURS NAT URALLY IN MANY FOODS & INVESTIGATION HAS NOT ESTABLISHED WHETHER IT/AN IMPURITY INTRODUCED DURING MFR/DISTRIBUTION IS THE CAUSE. CHRONIC: NONE SPECIFIED BY MFR (FP N). ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.