SIGMA-ALDRICH CHEMICAL CO -- LEUPEPTIN HYDROCHLORIDE, HIGH PURITY, L9783 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 03/16/1999 MSDS Num: CJPJD LIIN: 00N091813 Product ID: LEUPEPTIN HYDROCHLORIDE, HIGH PURITY, L9783 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA-ALDRICH CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Ingredients ======================================================= Cas: 24125-16-4 Name: LEUPEPTIN HYDROCHLORIDE LD50: (ORAL, RAT) 720 MG/KG FOR A CLOSELY RELATED COMPOUND, RTECS # YV420500 ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE INGREDIENT Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE EFFECTS: HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. BIOACTIVE PEPTIDE. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. A PROTEASE INHIBITOR. CHRONIC EFFECTS: OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH LABORATORY ANIMALS. TO THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL , PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: EYES: IN CASE OF CONTACT, IMMEDIATELY FLUSH EYES WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. SKIN: IN CASE OF CONTACT, IMMEDIATELY FLUSH SKIN WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIF FICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: EVACUATE AREA. WEAR NIOSH APPROVED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND REMOVED. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: POSSIBLE TERATOGEN. HARMFUL SOLID. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE. Other Precautions: AVOID INHALATION. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: NONCOMBUSTIBLE. USE EXTINGUISHING MEDIA APPROPRIATE TO SURROUNDING FIRE CONDITIONS. Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: USE ONLY IN A CHEMICAL FUME HOOD. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EYE WASH AND DELUGE SHOWER (FP N). OTHER PROTECTIVE CLOTHING. Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. ======================================================= Physical/Chemical Properties ======================================================= Appearance and Odor: SOLID. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Hazardous Decomposition Products: HAZARDOUS COMBUSTION OR DECOMPOSTION PRODUCTS: TOXIC FUMES OF CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES, HYDROGEN CHLORIDE GAS. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: SEE HLTH HAZS. RTECS DATA & SYNONYMS SUPPLIED ARE FOR CLOSELY RELATED CMPD. RTECS #:YV4205000. VALERAMIDE, 2-(2-ACETAMIDO-4-METHYLVALERAMIDE)-N-(1-FORMYL-4-GUANIDINOBUTYL)-4-METH. TOX DATA - LD50L SCU -RAT 1100 MG/KG; IVN-RAT 80 MG/KG; ORL-MUS 740 MG/KG; SCU-MUS 540 MG/KG; IVN-MUS 74 MG/KG (JZKEDZ 3,8.1977). TARGET ORGAN DATA: BEHAVIORAL (CONVLS/EFTS ON SEIZURE THRESHOLD). LUNGS, THORAX OR RESPIRAT ION (DYSPNAE) (OTHER CHGS). GI (OTHER CHGS). ONLY SELECTED REGISTRY OF RTECS DATA PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFO. ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: EUROPEAN INFORMATION: CAUTION: SUBSTANCE NOT YET FULLY TESTED. HARMFUL R 63 POSSIBLE RISK OF HARM TO THE UNBORN CHILD. R 20/21/22 HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. S 36 WEA R SUITABLE PROTECTIVE CLOTHING. RTECS DATA AND SYNONYMS SUPPLIED ARE FOR A CLOSELY RELATED COMPOUND. ======================================================= Other Information ======================================================= Other Information: MATERIAL WAS SHIPPED TO THIS ADDRESS: NATIONAL NAVAL MEDICAL CENTER, VERONICA SERRINO, BLDG 17 RM 10, 8901 WISCONSIN AVE, BETHEDSA MD 20889. ======================================================= HAZCOM Label ======================================================= Product ID: LEUPEPTIN HYDROCHLORIDE, HIGH PURITY, L9783 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 08/09/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Moderate Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE EFFECTS: HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. BIOACTIVE PEPTIDE. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. A PROTEASE INHIBITOR. CHRONIC EFFECTS: OVEREXPOSURE MAY CAUSE REPRODUCTIVE DISORDER(S) BASED ON TESTS WITH LABORATORY ANIMALS. TO THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL , PHYSICAL AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.