======================================================= MSDS Safety Information ======================================================= NAME: LIGHT GREEN FOR PAS ======================================================= SAFETY DATA SHEET 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING VENTANA MEDICAL SYSTEMS, INC. 1910 E. Innovation Park Drive Tucson, Arizona 85755 U.S.A. +1 (520) 887-2155 (800) 227-2155 (U.S.) EC REP Roche Diagnostics GmbH Roche Diagnostics Australia Pty. Ltd Sandhofer Strasse 116 31 Victoria Avenue D-68305 Mannheim Castle Hill, NSW, 2154 Germany Australia Phone: 61-2-9860-2329 Fax: 61-2-9860-2133 Emergency Phone Number: 61-2-9759-4301 SDS NUMBER: 00232095 SUBSTANCE: Light Green for PAS PRODUCT NUMBER(S): 860-010 PRODUCT USE: clinical/research CREATION DATE: Aug 22 2006 REVISION DATE: Mar 05 2009 2. HAZARDS IDENTIFICATION NFPA RATINGS (SCALE 0-4): HEALTH=1 FIRE=0 REACTIVITY=0 EC CLASSIFICATION: No classification assigned. EMERGENCY OVERVIEW: COLOUR: blue to green PHYSICAL FORM: liquid ODOUR: mild odour, vinegar odour MAJOR HEALTH HAZARDS: No significant target effects reported. POTENTIAL HEALTH EFFECTS: INHALATION: SHORT TERM EXPOSURE: irritation, cough, difficulty breathing, loss of voice, lung congestion, changes in blood pressure LONG TERM EXPOSURE: irritation, digestive disorders SKIN CONTACT: SHORT TERM EXPOSURE: irritation, skin disorders LONG TERM EXPOSURE: irritation, skin disorders EYE CONTACT: SHORT TERM EXPOSURE: irritation, lachrymation, eye damage, blindness LONG TERM EXPOSURE: irritation, lachrymation, eye damage, blindness INGESTION: SHORT TERM EXPOSURE: irritation, vomiting, diarrhoea, stomach pain, changes in body temperature, irregular heartbeat, difficulty breathing, loss of voice, lung congestion, blood disorders, convulsions LONG TERM EXPOSURE: irritation, vomiting, diarrhoea, stomach pain, changes in body temperature, irregular heartbeat, difficulty breathing, loss of voice, lung congestion, blood disorders, convulsions 3. COMPOSITION, INFORMATION ON INGREDIENTS COMPONENT: Non-hazardous CAS NUMBER: Not assigned. EC NUMBER: Not assigned. PERCENTAGE: 60-100 EC CLASSIFICATION: No classification assigned. COMPONENT: Acetic acid CAS NUMBER: 64-19-7 EC NUMBER (EINECS): 200-580-7 PERCENTAGE: 0.5-1.5 EC CLASSIFICATION: Flammable; C RISK PHRASES: 10-35 4. FIRST AID MEASURES INHALATION: If adverse effects occur, remove to uncontaminated area. Give artificial respiration if not breathing. Get immediate medical attention. SKIN CONTACT: Wash contaminated areas with soap and water. Thoroughly clean and dry contaminated clothing before reuse. Get medical attention, if needed. EYE CONTACT: Flush eyes with plenty of water for at least 15 minutes. Then get immediate medical attention. INGESTION: If a large amount is swallowed, get medical attention. 5. FIRE FIGHTING MEASURES FIRE AND EXPLOSION HAZARDS: Negligible fire hazard. EXTINGUISHING MEDIA: Use extinguishing agents appropriate for surrounding fire. FIRE FIGHTING: Move container from fire area if it can be done without risk. Avoid inhalation of material or combustion by-products. SENSITIVITY TO MECHANICAL IMPACT: Not sensitive SENSITIVITY TO STATIC DISCHARGE: Not sensitive FLASH POINT: not flammable HAZARDOUS COMBUSTION PRODUCTS: Thermal decomposition or combustion products: oxides of carbon, oxides of nitrogen, oxides of sulphur 6. ACCIDENTAL RELEASE MEASURES OCCUPATIONAL RELEASE: Absorb with sand or other non-combustible material. Collect spilled material in appropriate container for disposal. 7. HANDLING AND STORAGE STORAGE: Store and handle in accordance with all current regulations and standards. Store between 15 C and 30 C. See original container for storage recommendations. Keep separated from incompatible substances. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION EXPOSURE LIMITS: Acetic acid: 10 ppm (25 mg/m3) OSHA TWA 10 ppm ACGIH TWA 15 ppm ACGIH STEL 10 ppm (25 mg/m3) NIOSH recommended TWA 10 hour(s) 15 ppm (37 mg/m3) NIOSH recommended STEL 25 mg/m3 (10 ml/m3) DFG MAK (peak limitation category - I, with excursion factor of 2) VENTILATION: Provide adequate ventilation. Ensure compliance with applicable exposure limits. EYE PROTECTION: Safety glasses or goggles are recommended when there is a potential for eye contact. Provide an emergency eye wash fountain and quick drench shower in the immediate work area. CLOTHING: Lab coat or apron. GLOVES: Wear appropriate chemical resistant gloves. PROTECTIVE MATERIAL TYPES: latex, nitrile, vinyl RESPIRATOR: No respirator is required under normal conditions of use. 9. PHYSICAL AND CHEMICAL PROPERTIES PHYSICAL STATE: liquid APPEARANCE: clear COLOUR: blue to green ODOUR: mild odour, vinegar odour BOILING POINT: Not available FREEZING POINT: Not available VAPOUR PRESSURE: Not available VAPOUR DENSITY: Not available SPECIFIC GRAVITY: Not available WATER SOLUBILITY: miscible PH: acidic VOLATILITY: Not available ODOUR THRESHOLD: Not available EVAPORATION RATE: Not available COEFFICIENT OF WATER/OIL DISTRIBUTION: Not available 10. STABILITY AND REACTIVITY REACTIVITY: Stable at normal temperatures and pressure. CONDITIONS TO AVOID: None reported. INCOMPATIBILITIES: bases, acids, oxidising materials, carbonates, phosphates, hydroxides, oxides, sulphur, acid anhydrides, peroxides, permanganates, amines, alcohols HAZARDOUS DECOMPOSITION: Thermal decomposition or combustion products: oxides of carbon, oxides of nitrogen, oxides of sulphur POLYMERISATION: Will not polymerise. 11. TOXICOLOGICAL INFORMATION Acetic acid: IRRITATION DATA: 50 mg/24 hour(s) skin-human mild; 525 mg open skin-rabbit severe; 50 mg/24 hour(s) skin-rabbit mild; 5 mg/30 second(s) rinsed eyes-rabbit mild TOXICITY DATA: 5620 ppm/1 hour(s) inhalation-mouse LC50; 1060 uL/kg skin-rabbit LD50; 3310 mg/kg oral-rat LD50 LOCAL EFFECTS: Corrosive: inhalation, skin, eye, ingestion ACUTE TOXICITY LEVEL: Moderately toxic: inhalation, dermal absorption, ingestion MEDICAL CONDITIONS AGGRAVATED BY EXPOSURE: eye disorders, respiratory disorders, skin disorders and allergies 12. ECOLOGICAL INFORMATION Not available 13. DISPOSAL CONSIDERATIONS Dispose in accordance with all applicable regulations. 14. TRANSPORT INFORMATION U.S. DEPARTMENT OF TRANSPORTATION: Not regulated. CANADIAN TRANSPORTATION OF DANGEROUS GOODS: Not regulated. LAND TRANSPORT ADR: Not regulated. LAND TRANSPORT RID: Not regulated. AIR TRANSPORT IATA: Not regulated. AIR TRANSPORT ICAO: Not regulated. MARITIME TRANSPORT IMDG: Not regulated. 15. REGULATORY INFORMATION U.S. REGULATIONS: CERCLA SECTIONS 102a/103 HAZARDOUS SUBSTANCES (40 CFR 302.4): Acetic acid: 5000 LBS RQ SARA TITLE III SECTION 302 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart B): Not regulated. SARA TITLE III SECTION 304 EXTREMELY HAZARDOUS SUBSTANCES (40 CFR 355 Subpart C): Not regulated. SARA TITLE III SARA SECTIONS 311/312 HAZARDOUS CATEGORIES (40 CFR 370 Subparts B and C): ACUTE: No CHRONIC: No FIRE: No REACTIVE: No SUDDEN RELEASE: No SARA TITLE III SECTION 313 (40 CFR 372.65): Not regulated. STATE REGULATIONS: California Proposition 65: Not regulated. CANADIAN REGULATIONS: WHMIS CLASSIFICATION: Not a Controlled Product under Canada's Workplace Hazardous Material Information System. EUROPEAN REGULATIONS: EC CLASSIFICATION (CALCULATED): No classification assigned. 16. OTHER INFORMATION EC RISK PHRASES: R 10 Flammable. R 35 Causes severe burns. “RTECS®” is a United States trademark owned and licenced under authority of the U.S. Government, by and through Symyx Software, Inc. Portions ©Copyright 2001, U.S. Government. All rights reserved. Limitations: The information and recommendations set forth in this SDS are believed to be correct as of this date. Ventana Medical Systems, Inc. makes no warranty with respect to the content of this SDS and disclaims all liability from reliance thereon.