Dimension® system LIP Flex® reagent cartridge
Lipase Flex® reagent cartridge
Dimension® clinical chemistry system Flex® reagent cartridge LIP
DF55A
Pharmaceutical industry: Diagnostic agents.
Material Safety Data Sheet
Product name
Synonym
Material uses
Manufactured/supplied
Code
Product and company identification
Dimension® system LIP Flex® reagent cartridge
:
:
:
:
:
1 .
Product type : Liquid.
Dade Behring Inc.
Corporate Headquarters
1717 Deerfield Road
Deerfield, IL 60015-0778
1-847-267-5300
Dade Behring Canada Inc.
1200 Courtneypark Drive East
Mississauga, Ontario, Canada
L5T-1P2
(905) 564-7333
(800) 264-0083
Transportation: (800) 424-9300 (CHEMTREC)
Medical: (800) 228-5635 ext. 284 (Prosar)
MSDS no. DEDM0013
Absorbed through skin. Eye contact. Inhalation.
Emergency overview
Hazards identification
Routes of entry
Potential acute health effects
Severely irritating to the respiratory system.
Corrosive to eyes.
Harmful if swallowed. May cause burns to mouth, throat and stomach.
Corrosive to the skin.
Eyes
Skin
Inhalation
Ingestion
Physical state Solid
Danger!
CAUSES EYE AND SKIN BURNS.
CAUSES SEVERE RESPIRATORY TRACT IRRITATION.
CONTAINS MATERIAL WHICH CAUSES DAMAGE TO THE FOLLOWING ORGANS:
LUNGS, RESPIRATORY TRACT, SKIN, EYE, LENS OR CORNEA.
MAY BE HARMFUL IF SWALLOWED.
Corrosive to eyes and skin. Causes burns. Severely irritating to the respiratory system.
Avoid exposure - obtain special instructions before use. Do not breathe vapor or mist.
Do not get in eyes or on skin or clothing. Contains material that can cause target organ
damage. Use only with adequate ventilation. Keep container tightly closed and sealed
until ready for use. Wash thoroughly after handling.
:
:
:
:
:
:
:
OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard
(29 CFR 1910.1200).
2 .
Potential chronic health effects
Carcinogenicity : No known significant effects or critical hazards.
Mutagenicity : No known significant effects or critical hazards.
Teratogenicity : No known significant effects or critical hazards.
Developmental effects : No known significant effects or critical hazards.
Chronic effects : Contains material that can cause target organ damage.
Fertility effects : No known significant effects or critical hazards.
Over-exposure signs/symptoms
1/8 DF55A 8/29/2007.
Dimension® system LIP Flex® reagent cartridge
Hazards identification 2 .
See toxicological information (section 11)
Ingestion : Adverse symptoms may include the following:
stomach pains
Skin : Adverse symptoms may include the following:
pain or irritation
redness
blistering may occur
Eyes : Adverse symptoms may include the following:
pain
watering
redness
Inhalation : Adverse symptoms may include the following:
respiratory tract irritation
coughing
sucrose 57-50-1 93.08
1,3-propanediol, 2-amino-2-(hydroxymethyl)- 77-86-1 21.1
1,3-propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride 1185-53-1 14.3
poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- 25322-68-3 5
sodium hydroxide 1310-73-2 4
Composition/information on ingredients
Name CAS number %
sucrose 57-50-1 93.08
1,3-propanediol, 2-amino-2-(hydroxymethyl)- 77-86-1 21.1
sodium hydroxide 1310-73-2 4
Name CAS number %
United States
Canada
3 .
There are no additional ingredients present which, within the current knowledge of the supplier and in the
concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in
this section.
Move exposed person to fresh air. Loosen tight clothing such as a collar, tie, belt or
waistband. Do not induce vomiting unless directed to do so by medical personnel.
Never give anything by mouth to an unconscious person. Get medical attention
immediately.
Get medical attention immediately. Immediately flush eyes with plenty of water for at
least 15 minutes, occasionally lifting the upper and lower eyelids.
Flush contaminated skin with plenty of water. Remove contaminated clothing and
shoes. Wash clothing before reuse.
Get medical attention immediately. Move exposed person to fresh air. Loosen tight
clothing such as a collar, tie, belt or waistband. If not breathing, if breathing is irregular
or if respiratory arrest occurs, provide artificial respiration or oxygen by trained
personnel. The exposed person may need to be kept under medical surveillance for 48
hours.
First aid measures
Eye contact
Skin contact
Inhalation
Ingestion
:
:
:
:
4 .
Fire-fighting measures
Extinguishing media
Non-flammable.
5 .
None known. Not suitable :
Flammability of the product :
In case of fire, use water spray (fog), foam or dry chemical.
2/8 DF55A 8/29/2007.
Dimension® system LIP Flex® reagent cartridge
Fire-fighting measures 5 .
Special protective
equipment for fire-fighters
Fire-fighters should wear appropriate protective equipment and self-contained breathing
apparatus (SCBA) with a full face-piece operated in positive pressure mode.
:
Hazardous combustion
products
: Decomposition products may include the following materials:
carbon oxides
nitrogen oxides
sulfur oxides
halogenated compounds
metal oxide/oxides
No action shall be taken involving any personal risk or without suitable training.
Evacuate surrounding areas. Keep unnecessary and unprotected personnel from
entering. Do not touch or walk through spilled material. Avoid breathing vapor or mist.
Provide adequate ventilation. Put on appropriate personal protective equipment (see
section 8).
Environmental precautions
Accidental release measures
: Avoid dispersal of spilled material and runoff and contact with soil, waterways, drains
and sewers.
Personal precautions :
6 .
Stop leak if without risk. Move containers from spill area. Dilute with water and mop up
if water-soluble or absorb with an inert dry material and place in an appropriate waste
disposal container. Dispose of via a licensed waste disposal contractor.
Small spill :
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Do not ingest. Do not get in eyes or on skin or clothing. Keep container closed. Use
only with adequate ventilation. Avoid breathing vapor or mist. Wash thoroughly after
handling.
Handling and storage
Handling
Storage
:
:
7 .
sucrose ACGIH (United States, 1996).
TWA: 10 mg/m3
ACGIH TLV (United States, 1/2006). Notes: 1996 Adoption Refers to
Appendix A -- Carcinogens.
TWA: 10 mg/m3 8 hour(s).
sodium hydroxide ACGIH TLV (United States, 1/2006).
CEIL: 2 mg/m3
Exposure controls/personal protection
Product name Exposure limits
Consult local authorities for acceptable exposure limits.
sucrose ACGIH (United States, 1996).
TWA: 10 mg/m³
ACGIH TLV (United States, 1/2007).
TWA: 10 mg/m³ 8 hour(s).
sodium hydroxide ACGIH TLV (United States, 1/2007).
C: 2 mg/m³
United States
Canada
8 .
Engineering measures : Use only with adequate ventilation. If user operations generate dust, fumes, gas, vapor
or mist, use process enclosures, local exhaust ventilation or other engineering controls
to keep worker exposure to airborne contaminants below any recommended or statutory
limits.
Recommended monitoring
procedures
: If this product contains ingredients with exposure limits, personal, workplace atmosphere
or biological monitoring may be required to determine the effectiveness of the ventilation
or other control measures and/or the necessity to use respiratory protective equipment.
3/8 DF55A 8/29/2007.
Dimension® system LIP Flex® reagent cartridge
Exposure controls/personal protection 8 .
Use a properly fitted, air-purifying or air-fed respirator complying with an approved
standard if a risk assessment indicates this is necessary. Respirator selection must be
based on known or anticipated exposure levels, the hazards of the product and the safe
working limits of the selected respirator.
Safety eyewear complying with an approved standard should be used when a risk
assessment indicates this is necessary to avoid exposure to liquid splashes, mists,
gases or dusts.
Personal protective equipment for the body should be selected based on the task being
performed and the risks involved and should be approved by a specialist before handling
this product.
Personal protection
Eyes
Skin
Respiratory
:
:
:
Chemical-resistant, impervious gloves complying with an approved standard should be
worn at all times when handling chemical products if a risk assessment indicates this is
necessary.
Hands :
Hygiene measures : Wash hands, forearms and face thoroughly after handling chemical products, before
eating, smoking and using the lavatory and at the end of the working period. Appropriate
techniques should be used to remove potentially contaminated clothing. Wash
contaminated clothing before reusing. Ensure that eyewash stations and safety showers
are close to the workstation location.
Environmental exposure
controls
: Emissions from ventilation or work process equipment should be checked to ensure they
comply with the requirements of environmental protection legislation. In some cases,
fume scrubbers, filters or engineering modifications to the process equipment will be
necessary to reduce emissions to acceptable levels.
Solid
Basic.
May start to solidify at the following temperature: 0°C (32°F) This is based on data for
the following ingredient: water.
Weighted average: 1.23 (Water = 1)
Highest known value: 2.4 kPa (18 mm Hg) (at 20°C) (water).
Amphoteric. (water).
Easily soluble in the following materials: cold water.
Melting/freezing point
Physical and chemical properties
Physical state
pH
Relative density
Vapor pressure
Ionicity (in water)
Solubility
:
:
:
:
:
:
:
9 .
The product is stable. Under normal conditions of storage and use, hazardous
polymerization will not occur.
No specific data.
Will not occur.
Under normal conditions of storage and use, hazardous decomposition products should
not be produced.
No specific data.
Stability and reactivity
Stability
Conditions to avoid
Materials to avoid
Hazardous decomposition
products
Hazardous polymerization
:
:
:
:
:
10 .
Slightly flammable in the presence of the following materials or conditions: oxidizing
materials.
Non-flammable in the presence of the following materials or conditions: open flames,
sparks and static discharge and heat.
Slightly explosive in the presence of the following materials or conditions: oxidizing
materials.
Non-explosive in the presence of the following materials or conditions: open flames,
sparks and static discharge.
Conditions of reactivity
: Flammability
Explosibility :
4/8 DF55A 8/29/2007.
Dimension® system LIP Flex® reagent cartridge
Toxicological information
United States
Canada
11 .
Acute toxicity
sucrose LD50 Oral Rat 29700 mg/kg -
1,3-propanediol, 2-amino-2-
(hydroxymethyl)-
LD50 Intravenous Rat 1800 mg/kg -
LD50 Oral Rat 5900 mg/kg -
Product/ingredient name Result Species Dose Exposure
Acute toxicity
1,3-propanediol, 2-amino-2-
(hydroxymethyl)-
LD50 Intravenous Rat 1800 mg/kg -
LD50 Oral Rat 5900 mg/kg -
sucrose LD50 Oral Rat 29700 mg/kg -
Product/ingredient name Result Species Dose Exposure
Chronic toxicity
Not available.
Carcinogenicity
Not available.
Mutagenicity
Not available.
Teratogenicity
Not available.
Reproductive toxicity
Not available.
Chronic toxicity
Not available.
Carcinogenicity
Not available.
Mutagenicity
Not available.
Teratogenicity
Not available.
Reproductive toxicity
Not available.
Classification
sucrose A4 - - None. - -
Product/ingredient name ACGIH EPA NIOSH NTP IARC OSHA
Classification
sucrose A4 - - None. - -
Product/ingredient name ACGIH EPA NIOSH NTP IARC OSHA
5/8 DF55A 8/29/2007.
Dimension® system LIP Flex® reagent cartridge
Ecological information
United States
Canada
Environmental effects : No known significant effects or critical hazards.
12 .
Aquatic ecotoxicity
poly(oxy-1,2-ethanediyl), a-hydro-?-
hydroxy-
- Acute LC50
>20000000 ug/L
Fresh water
Fish - Carassius
carassius
96 hours
- Acute LC50
>20000000 ug/L
Fresh water
Fish -
Oncorhynchus
mykiss
96 hours
- Acute LC50
>1000000 ug/L
Fresh water
Fish - Salmo
salar
96 hours
sodium hydroxide - Acute EC50
40.38 to 47.13
mg/L Fresh water
Daphnia -
Ceriodaphnia
dubia
48 hours
- Acute LC50
125000 ug/L
Fresh water
Fish - Gambusia
affinis
96 hours
Product/ingredient name Test Species Result Exposure
Biodegradability
Not available.
Aquatic ecotoxicity
sodium hydroxide - Acute EC50
40.38 to 47.13
mg/L Fresh water
Daphnia -
Ceriodaphnia
dubia
48 hours
- Acute LC50
125000 ug/L
Fresh water
Fish - Gambusia
affinis
96 hours
Product/ingredient name Test Species Result Exposure
Biodegradability
Not available.
The generation of waste should be avoided or minimized wherever possible. Avoid
dispersal of spilled material and runoff and contact with soil, waterways, drains and
sewers. Disposal of this product, solutions and any by-products should at all times
comply with the requirements of environmental protection and waste disposal legislation
and any regional local authority requirements.
Waste disposal
Disposal considerations
Disposal should be in accordance with applicable regional, national and local laws and regulations.
:
13 .
Refer to Section 7: HANDLING AND STORAGE and Section 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
for additional handling information and protection of employees.
Transport information
8 - DOT Classification sodium hydroxide
solution (sodium
hydroxide)
III
Regulatory
information
UN number Proper shipping
name
Classes PG* Label Additional
information
1824
14 .
6/8 DF55A 8/29/2007.
Dimension® system LIP Flex® reagent cartridge
Transport information 14 .
TDG Classification 8 1824 SODIUM
HYDROXIDE,
SOLUTION (sodium
hydroxide)
III
ADR/RID Class Sodium hydroxide
solution (sodium
hydroxide)
8 III
IMDG Class Sodium hydroxide
solution (sodium
hydroxide)
8 III
Sodium hydroxide
solution (sodium
hydroxide)
1824 IATA-DGR Class 8 III
1824
1824
-
-
-
-
PG* : Packing group
Corrosive material
Target organ effects
HCS Classification
Regulatory information
U.S. Federal regulations
Rhode Island Hazardous Substances: sucrose
Pennsylvania RTK Hazardous Substances: sucrose: (generic environmental hazard);
sodium hydroxide: (environmental hazard, generic environmental hazard)
Minnesota: sucrose; poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-
Massachusetts Substances: sucrose; sodium hydroxide
New Jersey: sodium hydroxide
United States inventory (TSCA 8b): Not determined.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: sodium hydroxide
Clean Air Act (CAA) 112 accidental release prevention: No products were found.
Clean Air Act (CAA) 112 regulated flammable substances: No products were found.
Clean Air Act (CAA) 112 regulated toxic substances: No products were found.
State regulations
CEPA DSL: water; sucrose; 1,3-propanediol, 2-amino-2-(hydroxymethyl)-; 1,3-
propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride; poly(oxy-1,2-ethanediyl),
.alpha.-hydro-.omega.-hydroxy-; sodium hydroxide
WHMIS (Canada) Not a WHMIS controlled material.
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: sucrose; sodium hydroxide
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: sucrose:
Delayed (chronic) health hazard; sodium hydroxide: Immediate (acute) health hazard
:
:
:
:
Canada
United States
15 .
This product has been classified according to the hazard criteria of the CPR and the MSDS contains all the
information required by the CPR.
Canadian lists :
United States inventory
(TSCA 8b)
: United States inventory (TSCA 8b): Not determined.
Canada inventory : Canada inventory: Not determined.
7/8 DF55A 8/29/2007.
Dimension® system LIP Flex® reagent cartridge
Other information
CAUSES EYE AND SKIN BURNS.
CAUSES SEVERE RESPIRATORY TRACT IRRITATION.
CONTAINS MATERIAL WHICH CAUSES DAMAGE TO THE FOLLOWING ORGANS:
LUNGS, RESPIRATORY TRACT, SKIN, EYE, LENS OR CORNEA.
MAY BE HARMFUL IF SWALLOWED.
Label requirements :
Notice to reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above-named
supplier, nor any of its subsidiaries, assumes any liability whatsoever for the accuracy or completeness of the
information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present
unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot
guarantee that these are the only hazards that exist.
Date of printing
Date of issue
Version
8/29/2007.
8/29/2007.
1.05
:
:
:
16 .
The customer is responsible for determining the PPE code for this material.
Australia inventory (AICS): All components are listed or exempted.
China inventory (IECSC): Not determined.
Korea inventory (KECI): Not determined.
Philippines inventory (PICCS): Not determined.
Japan inventory (ENCS): Not determined.
International regulations
International lists :
S26- In case of contact with eyes, rinse immediately with plenty of water and seek
medical advice.
S36/37/39- Wear suitable protective clothing, gloves and eye/face protection.
S45- In case of accident or if you feel unwell, seek medical advice immediately (show the
label where possible).
R34- Causes burns. Risk phrases
EU regulations
Safety phrases
:
:
Hazard symbol or symbols :
8/8 DF55A 8/29/2007.