LISTERIA Selective Supplement (Oxford Formulation) Section 1. Chemical Product and Company Identification SR0140 Product No. LISTERIA Selective Supplement (Oxford Formulation) Trade name Manufacturer Oxoid Ltd Wade Road Basingstoke Hants. RG24 8PW Tel. 44 (0) 1256 841144 Fax. 44 (0) 1256 463388 Section 2. Composition, Information on Ingredients Preparation - Hazardous ingredients ( Europe ) Concentration Component CAS No. / EINECS Number 25.80 % w/w Cycloheximide 66-81-9 200-636-0 1264-72-8 26016-99-9 8048-52-0 Colistin Sulphate Fosfomycin Acriflavine 5.30 % w/w 2.60 % w/w 1.30 % w/w Most Important Hazards *** Revised *** Very toxic if swallowed. May cause sensitization by inhalation and skin contact. May cause heritable genetic damage. May cause harm to the unborn child. Repeated and/or prolonged contact may lead to dermatitis. Human health hazards - Skin Human health hazards - Ingestion Human health hazards - Inhalation Swallowing may have the following effects:- excitement, tremors, salivation, and melena. Mechanisms of toxicity are not well defined but probably include gastrointestinal irritation, central nervous system stimulation, renal injury and damage to the adrenal cortex. Inhalation may cause pulmonary sensitisation and may cause bronchial spasms in asthma. Exposure to dust may have the following effects:- irritation of nose, throat and respiratory tract. First Aid - Eyes First Aid - Skin First Aid - Ingestion First Aid - Inhalation Notes to physician Check for and remove any contact lenses. In case of contact, immediately flush eyes with a copious amount of water for at least 15 minutes. Wash skin thoroughly with soap and water. Obtain medical attention urgently. Wash out mouth with water. Have victim drink 1-3 glasses of water to dilute stomach contents. Obtain medical attention urgently. In case of accident by inhalation: remove casualty to fresh air and keep at rest. Seek medical attention if you feel unwell. Remove toxicant from gut by gastric lavage. Instill activated carbon, then a cathartic dose of Sodium Sulphate. Intravenous fluids may accelerate excretion. Hydrocortisone appears to be antidotal particularly in combination with the adenergic agent Methoxyphenamine (Orthoxine). Atropine may relieve the cholinergic symptoms. CM Version - 3 Section 3. Hazards Identification Section 4. First Aid Measures Date of issue - 13/08/2002. Classification T+, N Xn Xn T SR0140 Risk Phrases R28, R51/53, R61, R68 R36/37, R42 R22, R43 R36/37/38, R46 Page: 1/3 SAFETY DATA SHEET Section 5. Fire Fighting Measures Extinguishing Media - Suitable Special fire-fighting procedures Section 6. Accidental Release Measures Personal Precautions Environmental precautions and cleanup methods Spill Wear appropriate protective clothing. Try to prevent the material from entering drains or water courses. Sweep or preferably vacuum up and collect in suitable containers for recovery or disposal. Avoid contact with eyes, skin and clothing. Avoid inhaling dust. Use local exhaust ventilation. Storage temperature should be controlled to between 2 and 8 °C. Section 7. Handling and Storage Handling Storage Section 8. Exposure Controls, Personal Protection Occupational Exposure Limits ( Preparation ) - Europe Cycloheximide Engineering measures Protective Measures - Respiratory Protective Measures - Hands Protective Measures - Eyes Protective Measures - Body None assigned. Handle the material in a fume hood/cupboard or under local exhaust ventilation. Dusk mask to EN149 FFP2S. Disposable vinyl gloves. Recommended: Safety glasses or chemical goggles to EN166, 167 and 168. Lab coat. LISTERIA Selective Supplement (Oxford Formulation) SAFETY DATA SHEET Date of issue - 13/08/2002. Use water spray, foam, dry chemical or carbon dioxide. This product may give rise to hazardous fumes in a fire. SR0140 Page: 2/3 Section 9. Physical and Chemical Properties Physical state Colour Section 10. Stability and Reactivity Stability Materials to avoid Hazardous decomposition products Section 11. Toxicological Information Acute toxicity Eye irritation Sensitization - Skin Sub-Chronic toxicity Mutagenic Effects Developmental toxicity CM Version - 3 Pellets. Pale Yellow. Stable under normal conditions. Decomposes at temperatures above 100 °C. Alkalis. Heating may produce: oxides of nitrogen. oxides of carbon. Very toxic if swallowed. The degree of irritation was insufficient to warrant labelling as an eye irritant. The possibility of allergic sensitisation should be considered. The following tissues were affected: - kidney - peripheral neuropathy EU Category 2: Regarded as mutagenic to humans. May cause harm to the unborn child. Ecotoxicity Disposal considerations Container information UN number Proper shipping name Class Packing group UN : UN : UN : UN : LISTERIA Selective Supplement (Oxford Formulation) Section 12. Ecological Information Section 13. Disposal Considerations Section 14. Transport Information Section 15. Regulatory Information Date of issue - 13/08/2002. No relevant studies identified. 2811 Toxic solid, organic, n.o.s. 6.1 II Very toxic 27/09/1995 13/08/2002 SR0140 Hazardous waste. Dispose of according to all federal, state and local applicable regulations. Labels should not be removed from containers until they have been cleaned. Containers should be cleaned by appropriate methods and then re-used or disposed of by landfill or incineration as appropriate. *** Revised *** R28- Very toxic if swallowed. R42/43- May cause sensitization by inhalation and skin contact. R46- May cause heritable genetic damage. R61- May cause harm to the unborn child. *** Revised *** S53- Avoid exposure - obtain special instructions before use. S22- Do not breathe dust. S36/37- Wear suitable protective clothing and gloves. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). T+ - Very toxic. Xn - Harmful. Mutagen, Category 2. Toxic for reproduction, Category 2. Most Important Hazards Risk Phrases Safety Phrases Classification and labelling have been performed according to EU directives 67/548/EEC, 88/379/EEC, including amendments and the intended use. Page: 3/3 SAFETY DATA SHEET Label Requirements Risk Phrases Safety Phrases EC Classification Section 16. Other Information MSDS first issued MSDS data revised Revisions Highlighted Notes CM Version - 3