SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 09/OCT/2003 
Date Updated: 06/APR/2002 
Version 1.0 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name METANEPHRINE HYDROCHLORIDE, 99% 
Product Number 274283 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
D-L-METANEPHRINE HYDROCHLORIDE 881-95-8 212-922-2 
Formula C10H15NO3.ClH 
Molecular Weight 233.7 AMU 
Synonyms Adrenaline, 3-methoxy-, hydrochloride, 
(+-)-4-Hydroxy-3-methoxy-alpha-((methylamino)meth 
yl)benzenemethanol hydrochloride, 
(+-)-Metanephrine hydrochloride,Vanillyl alcohol, 
alpha-((methylamino)methyl)-, 
hydrochloride (8CI), 
dl-Metanephrine hydrochloride 
3 - Hazards Identification 
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT 
Irritating to eyes, respiratory system and skin. 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If not breathing give 
artificial respiration. If breathing is difficult, give oxygen. 
AFTER SKIN CONTACT 
In case of contact, immediately wash skin with soap and copious 
amounts of water. 
AFTER EYE CONTACT 
In case of contact, immediately flush eyes with copious amounts 
of water for at least 15 minutes. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician. 
5 - Fire Fighting Measures
EXTINGUISHING MEDIA 
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam. 
SPECIAL RISKS 
Specific Hazard(s): Emits toxic fumes under fire conditions. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear respirator, chemical safety goggles, rubber boots, and 
heavy rubber gloves. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Do not breathe dust. Avoid contact 
with eyes, skin, and clothing. Avoid prolonged or repeated 
exposure. 
STORAGE 
Conditions of Storage: Keep tightly closed. Store in the dark. 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Safety shower and eye bath. Mechanical exhaust required. 
GENERAL HYGIENE MEASURES 
Wash thoroughly after handling. 
PERSONAL PROTECTIVE EQUIPMENT 
Respiratory Protection: Government approved respirator. 
Hand Protection: Compatible chemical-resistant gloves. 
Eye Protection: Chemical safety goggles. 
9 - Physical and Chemical Properties 
Appearance Physical State: Solid 
Color: White 
Property Value At Temperature or Pressure 
pH N/A 
BP/BP Range N/A 
MP/MP Range 175 °C 
Flash Point N/A 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
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Vapor Pressure N/A 
Partition Coefficient N/A 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. N/A 
Solvent Content N/A 
Water Content N/A 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility N/A 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Conditions to Avoid: Sensitive to light. 
Materials to Avoid: Strong oxidizing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, 
Nitrogen oxides, Hydrogen chloride gas. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: DA4798000 
SIGNS AND SYMPTOMS OF EXPOSURE 
To the best of our knowledge, the chemical, physical, and 
toxicological properties have not been thoroughly investigated. 
ROUTE OF EXPOSURE 
Skin Contact: Causes skin irritation. 
Skin Absorption: May be harmful if absorbed through the skin. 
Eye Contact: Causes eye irritation. 
Inhalation: Material is irritating to mucous membranes and upper 
respiratory tract. May be harmful if inhaled. 
Ingestion: May be harmful if swallowed. 
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Contact a licensed professional waste disposal service to dispose 
of this material. Dissolve or mix the material with a combustible 
solvent and burn in a chemical incinerator equipped with an 
afterburner and scrubber. Observe all federal, state, and local 
environmental regulations. 
14 - Transport Information 
RID/ADR 
Non-hazardous for road transport. 
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IMDG 
Non-hazardous for sea transport. 
IATA 
Non-hazardous for air transport. 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
INDICATION OF DANGER: Xi 
Irritant. 
R-PHRASES: 36/37/38 
Irritating to eyes, respiratory system and skin. 
S-PHRASES: 26 36 
In case of contact with eyes, rinse immediately with plenty of 
water and seek medical advice. Wear suitable protective 
clothing. 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
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