SIGMA CHEMICAL CO -- METHANESULFONIC ACID ETHYL ESTER, M0880 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 01/01/1999 MSDS Num: CJVMK LIIN: 00N092665 Product ID: METHANESULFONIC ACID ETHYL ESTER, M0880 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Ingredients ======================================================= Cas: 62-50-0 RTECS #: PB2100000 Name: METHANESULFONIC ACID ETHYL ESTER Percent by Wt: 100. Other REC Limits: N/K (FP N) OSHA PEL: N/K (FP N) OSHA STEL: N/K (FP N) ACGIH TLV: N/K (FP N) ACGIH STEL: N/K (FP N) ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE TOXICOLOGICAL INFORMATION. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: YES IARC: YES OSHA: NO Effects of Exposure: ACUTE: HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. CHRONIC: CARCINOGEN. MAY ALTER GENETIC MATERIAL. TARGET ORGANS: LUNGS, KIDNEYS. Explanation Of Carcinogenicity: METHANESULFONIC ACID ETHYL ESTER: IARC MONOGRAPHS, SUPPLEMENT, VOLUME 7, PAGE 56, 1987: GROUP 2B. NTP 8TH ANNUAL REPORT ON CARCINOGENS, 1998: REASONABLY ANTICIPATED TO BE HUMAN CARCINOGEN. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: EVACUATE AREA. WEAR NIOSH APPROVED SCBA, RUBBER BOOTS AND HEAVY RUBBER GLOVES. WEAR DISPOSABLE COVERALLS AND DISCARD THEM AFTER USE. COVER WITH DRY LIME OR SODA ASH, PICK UP, KEEP IN A CLOSED CONTAINE R AND HOLD FOR WASTE DISPOSAL. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. RC RA WASTE NUMBER U119. Handling And Storage Precautions: DO NOT BREATHE VAPOR. AVOID ALL CONTACT. TOXIC. CARCINOGEN. MUTAGEN. HARMFUL LIQ & FUMES. KEEP TIGHTLY CLOSED. STORE IN COOL DRY PLACE. LABEL PREC STATEMENTS: TOXIC. MAY CAUSE CANCER. MAY CAUSE HERITA BLE GENETIC DMG. HARMFUL BY INHAL, IN CONT W/SKIN & IF SWALLOWED. TARGET ORGAN(S): LUNGS, KIDNEYS. Other Precautions: IN CASE OF ACCIDENT OR IF YOU FEEL UNWELL, SEEK MEDICAL ADVICE IMMEDIATELY (SHOW LABEL WHERE POSSIBLE). WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE PROTECTION. DO NOT BREATHE VAPOR. INGREDI ENT INFORMATION: MF: C*3H*8O*3S. EC NO: 200-536-7. ======================================================= Fire and Explosion Hazard Information ======================================================= Flash Point: =100.C, 212.F Extinguishing Media: WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: USE ONLY IN A CHEMICAL FUME HOOD. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EMERGENCY EYEWASH AND DELUGE SHOWER (FP N). WEAR OTHER PROTECTIVE CLOTHING. Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. Supplemental Safety and Health: TOX INFO: SPECIFIC DEVEL ABNORMS (CRANIOFACIAL, MUSCOLESKETAL SYS, OTHER DEVEL ABNORMS); TUMORIGENIC EFTS (TRANSPLACENTAL TUMORIGENESIS); EFTS ON NEWBORN (LIVE BIRTH INDEX, GERM CELL EFTS, DELAYED EFT S); TUMORIGENIC (CARCIN BY RTECS CRITERIA, NEOPLASTIC BY RTECS CRITERIA, EQUIVOCAL TUMORIGENIC AGENT BY (OTHER INFO) ======================================================= Physical/Chemical Properties ======================================================= Boiling Point: >85.C, 185.F B.P. Text: 85C - 86C/10MM Spec Gravity: 1.167 Appearance and Odor: COLORLESS TO YELLOW LIQUID. ======================================================= Reactivity Data ======================================================= Materials To Avoid: STRONG OXIDIZING AGENTS, STRONG BASES. Hazardous Decomposition Products: TOXIC FUMES OF CARBON MONOXIDE, CARBON DIOXIDE, SULFUR OXIDES. ======================================================= Toxicological Information ======================================================= Toxicological Information: RTECS #: PB2100000-METHANESULFONIC ACID, ETHYL ESTER. TOXICITY DATA: IPR-RAT LD50: 350 MG/KG; CPBTAL 8, 807, 1960. ORL-MUS LD50: 470 MG/KG; MUREAV 223, 373, 1989. IPR-MUS LD50: 435 MG/KG; CBINA8 3, 11 7, 1971. TARGET ORGAN DATA: BRAIN & COVERINGS (TUMORS); LUNGS, THORAX/RESP (TUMORS); KIDNEY, URETER, BLADDER (KIDNEY TUMORS); SKIN & APPENDAGES (TUMORS); PATERNAL EFTS (SPERMATOGENESIS, TESTES, EPIDID YMIS, SPERM DUCT); EFTS ON FERTILITY (MATING PERFORMANCE, MALE FERTILITY INDEX, PRE-IMPLANTATION MORTALITY, POST-IMPLANTATION MORTALITY, LITTER SIZE); EFTS ON EMBRYO/FETUS (FETOTOXICITY, FETAL DEATH, OTHER EFTS TO EMBRYO/FETUS); (SUP DAT) ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. --OTHER INFO: POS: MAMMALIAN MICRONUCLEUS; POS: IN VITRO HUMAN LYMPHOCYTE MICRONUCLEUS, MOUSE SPOT TEST; POS: N CRASSA-FORWARD MUTATION, N CRASSA-REVERSION; POS: E COLI POLA W/ OUT S9, IN VITRO SCE-HUMAN LYMPHOCYTES; POS: MOUSE SPECIFIC LOCUS, SPERM MORPHOLOGY-MOUSE F1; POS: SPERM MORPHOLOGY-MOUSE, D MELANOGASTER SEX-LINKED LETHAL; POS: UDS IN MOUSE GERM CELLS, V79 CELL CULT URE-GENE MUTATION; POS: TRP REVERSION, S CEREVISIAE GENE CONVERSION; POS: S CEREVISIAE-FORWARD MUTATION, S CEREVISIAE-HOMOZYGOSIS; POS: S CEREVISIAE-ANEUPLOIDY, S CEREVISIAE-REVERSION; (TRANSPORT INFO ) ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORATION INFORMATION. --ECOLOGICAL INFO: POS: S POMBE-FORWARD MUTATION, S POMBE-REVERSION; POS/DOSE RESPONSE: RODENT DOMINANT LETHAL; POS/DOSE RESPONSE: RODENT HERITABLE TRANSLOCATION; POS/DOSE RESPONSE: IN VITRO SCE-HUMAN, IN VITRO SCE-NONHUMAN; POS/DOSE RESPONSE: IN VIVO SCE-NONHUMAN; POS/DOSE RESPONSE: IN VITRO UDS-HUMAN FIBROBLAST; NEG: N CRASSA-ANEUPLOI DY; INCONCLUSIVE: CYTOGENETICS-MALE GERM CELL. EPA TSCA SECTION 8 (B) CHEM INVENTORY. EPA TSCA SECTION 8 (D) UNPUBLISHED HLTH/SFTY STUDIES. EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998. (SAR A REGS) ======================================================= Regulatory Information ======================================================= Sara Title III Information: N/P --TRANSPORT INFO: NTP 7TH ANNUAL REPORT ON CARCINOGENS, 1992: ANTICIPATED TO BE CARCINOGEN. Federal Regulatory Information: EUROPEAN INFO: TOX. R 45: MAY CAUSE CANCER. R 46: MAY CAUSE HERITABLE GENETIC DMG. R 20/21/22: HARMFUL BY INHAL, IN CONT W/SKIN & IF SWALLOWED. S 45: IN CASE OF ACCIDENT/IF YOU FEEL UNWELL, SEEK MED A DVICE IMMED (SHOW LABEL WHERE POSS). S 36/37/39: WEAR SUITABLE PROT CLTHG, GLOVES & EYE/FACE PROT. S 23: DO NOT BREATHE VAP. REVIEWS, STDS, & REGS: OEL=MAK. IARC CANCER REVIEW: ANIMAL SUFFICIENT EVIDE NCE; IMEMDT 7, 245, 1974. IARC CANCER REVIEW: HUMAN NO ADEQ DATA; IMEMDT 7, 245, 1974. IARC CANCER R EVIEW: GROUP 2B; IMSUDL 7, 56, 1987. OEL-FINLAND, OEL-SWEDEN: CARCIN JAN 1993. (OTHER INFO) State Regulatory Information: CALIFORNIA PROPOSITION 65: THIS PRODUCT IS OR CONTAINS CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER. ======================================================= Other Information ======================================================= Other Information: SUP DAT: RTECS CRITERIA). ONLY SELECTED REGISTRY OF TOX EFTS OF CHEM SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFO. FED REGS: NOES 1983: HZD X6247; NIS 1; TNF 75; NOS 2; TNE 971; TFE 448. INFO FOR EPA GENETOX PROGRAM 1988: POS: ASPERGILLUS-FORWARD MUTATION, ASPERGILLUS-REVERSION; POS: CARCINOGENICITY-MOUSE/RAT, SHE-CLONAL ASSAY; POS: SHE-FOCUS ASSAY, CELL T RANSFORMATION-SA7/SHE; POS: IN VIVO CYTOGENETICS-NONHUMAN BONE MARROW; POS: D MELANOGASTER-RECIPROCAL TRANSLOCATION; POS: HOST-MEDIATED ASSAY, L5178Y CELLS IN VITRO-TK TEST; (ECOLOGICAL INFO) ======================================================= HAZCOM Label ======================================================= Product ID: METHANESULFONIC ACID ETHYL ESTER, M0880 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 11/02/1999 Status Code: A Origination Code: F Chronic Hazard IND: Y Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: NO Health Hazard: Moderate Contact Hazard: Moderate Fire Hazard: Slight Reactivity Hazard: None Hazard And Precautions: ACUTE: HARMFUL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION. CHRONIC: CANCER HAZARD. PRODUCT IS LISTED AS AN ANIMAL KIDNEY CARCINOGEN (FP N). MAY ALTER GENETIC MATERIAL. TARGE T ORGANS: LUNGS, KIDNEYS. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.