SIGMA CHEMICAL CO -- N-ACETYL-L-CYSTEINE SIGMA GRADE, A7250 ======================================================= MSDS Safety Information ======================================================= FSC: 6810 NIIN: 01-373-3540 MSDS Date: 01/01/1999 MSDS Num: CJQPM Product ID: N-ACETYL-L-CYSTEINE SIGMA GRADE, A7250 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Item Description Information ======================================================= Item Name: ACETYLCYSTEINE,USP ======================================================= Ingredients ======================================================= Cas: 616-91-1 RTECS #: HA1660000 Name: N-ACETYL-L-CYSTEINE. LD50:(ORAL,RAT) 5050 MG/KG. ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE INGREDIENTS & TOX INFORMATION. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. EXPOSURE CAN CAUSE BRONCHOSPASM, NAUSEA, VOMITING, STOMATITIS, AND NASAL DISCHARGE. TARGET ORGAN DATA: GASTROINTESTINAL (OTHER CHANGE S). Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL MD. SKIN: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES. CALL MD. INHALATI ON: REMOVE TO FRESH AIR. IF BREATHING BECOMES DIFFICULT, CALL MD. EYES: FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING EYELIDS WITH FINGERS. CALL M D. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR PROTECTIVE EQUIPMENT. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: CAUTION: AVOID CONTACT AND INHALATION. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: ANSI APPROVED EYE WASH & DELUGE SHOWER (FP N). WEAR OTHER PROTECTIVE CLOTHING. ======================================================= Physical/Chemical Properties ======================================================= Melt/Freeze Pt: >109.C, 228.2F M.P/F.P Text: 109-111C Appearance and Odor: WHITE CRYSTALS. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Materials To Avoid: HEAVY METALS, HEAVY METAL SALTS, RUBBER, OXYGEN, OXIDIZING AGENTS. Hazardous Decomposition Products: TOXIC FUMES OF: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES, SULFUR OXIDES. Hazardous Polymerization Indicator: NO Conditions To Avoid Polymerization: WILL NOT OCCUR. ======================================================= Toxicological Information ======================================================= Toxicological Information: TOX DATA: LD50:(ORAL,RAT) 5050 MG/KG - TXAPA9 18,185,1971. LD50:(IVN,RAT) 1140 MG/KG - EJRDD2 61 (SUPPL 111),45,1980. LD50:(ORAL,MUS) 4400 MG/KG - EPXXDW #0192191. LD50:(IPR,MUS) 400 MG/KG - NTIS** AD 691-490. LD50:(IVN,MUS) 3800 MG/KG - JMCMAR 10,1172,1967. LD50:(ORAL,DOG) >1 GM/KG - PBPSDY 2,479,1979. LD50:(IPR,DOG) 700 MG/KG - PBPSDY 2,479,1979. LD50:(IVN,DOG) 700 MG/KG - PBPSDY 2,479,1979. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: REVIEWS, STANDARDS AND REGULATIONS: OEL=MAK. NOHS 1974: HZD 81688; NIS 1; TNF 616; NOS 6; TNE 4525. NOES 1983: HZD 81688; NIS 1; TNF 1677; NOS 14; TNE 31203; TFE 21201. EPA TSCA SECTION 8(B) CHEMICAL INVENTORY. ======================================================= Other Information ======================================================= Other Information: MFR'S INFO: MF: C5H9NO3S. EC NO: 210-498-3. ======================================================= Transportation Information ======================================================= Responsible Party Cage: 21076 Trans ID NO: 150544 Product ID: N-ACETYL-L-CYSTEINE SIGMA GRADE, A7250 MSDS Prepared Date: 01/01/1999 Review Date: 12/06/1999 MFN: 1 Multiple KIT Number: 0 ======================================================= Detail DOT Information ======================================================= DOT PSN Code: ZZZ DOT Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION ======================================================= Detail IMO Information ======================================================= IMO PSN Code: ZZZ IMO Proper Shipping Name: NOT REGULATED FOR THIS MODE OF TRANSPORTATION ======================================================= Detail IATA Information ======================================================= IATA PSN Code: ZZZ IATA Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION ======================================================= Detail AFI Information ======================================================= AFI PSN Code: ZZZ AFI Proper Shipping Name: NOT REGULATED BY THIS MODE OF TRANSPORTATION ======================================================= HAZCOM Label ======================================================= Product ID: N-ACETYL-L-CYSTEINE SIGMA GRADE, A7250 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 09/08/1999 Status Code: A Origination Code: F Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Slight Fire Hazard: Slight Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION OR SKIN ABSORPTION. EXPOSURE CAN CAUSE BRONCHOSPASM, NAUSEA, VOMITING, STOMATITIS, AND NASAL DISCHARGE. TARGET ORGAN DATA: GASTROINTESTINAL (OTHER CHANGE S). CHRONIC: NONE LISTED BY MANUFACTURER. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.