SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 09/OCT/2003 
Date Updated: 06/APR/2002 
Version 1.1 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name N-METHYL-D-ASPARTIC ACID 
Product Number 65831 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
N-METHYL-D-ASPARTIC ACID 6384-92-5 None 
Formula C5H9NO4 
Molecular Weight 147 AMU 
Synonyms N-Methyl-D-aspartate,N-Methyl-D-aspartic acid, 
NMDA 
3 - Hazards Identification 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If breathing becomes difficult, 
call a physician. 
AFTER SKIN CONTACT 
In case of skin contact, flush with copious amounts of water for 
at least 15 minutes. Remove contaminated clothing and shoes. 
Call a physician. 
AFTER EYE CONTACT 
In case of contact with eyes, flush with copious amounts of 
water for at least 15 minutes. Assure adequate flushing by 
separating the eyelids with fingers. Call a physician. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician. 
5 - Fire Fighting Measures 
EXTINGUISHING MEDIA 
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Exercise appropriate precautions to minimize direct contact with 
skin or eyes and prevent inhalation of dust. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Avoid inhalation. Avoid contact 
with eyes, skin, and clothing. Avoid prolonged or repeated 
exposure. 
STORAGE 
Conditions of Storage: Keep tightly closed. Store in a cool dry 
place. 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Safety shower and eye bath. Use only in a chemical fume hood. 
GENERAL HYGIENE MEASURES 
Wash thoroughly after handling. 
PERSONAL PROTECTIVE EQUIPMENT 
Respiratory Protection: Wear dust mask. 
Hand Protection: Protective gloves. 
Eye Protection: Chemical safety goggles. 
9 - Physical and Chemical Properties 
Appearance Physical State: Solid 
Color: White 
Form: Powder 
Property Value At Temperature or Pressure 
pH N/A 
BP/BP Range N/A 
MP/MP Range 189 - 190 °C 
Flash Point N/A 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
Partition Coefficient N/A 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
FLUKA - 65831 www.sigma-aldrich.com Page 2
Bulk Density N/A 
Decomposition Temp. N/A 
Solvent Content N/A 
Water Content N/A 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility Solvent: 0.1 g/ml HCl 1.0 M complete, 
colorless 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Materials to Avoid: Strong acids, Strong bases. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Thermal decomposition may 
produce carbon monoxide, carbon dioxide, and nitrogen oxides. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: CI9457000 
ACUTE TOXICITY 
LD50 
Intraperitoneal 
Mouse 
137 MG/KG 
Remarks: Behavioral:Convulsions or effect on seizure threshold. 
SIGNS AND SYMPTOMS OF EXPOSURE 
To the best of our knowledge, the chemical, physical, and 
toxicological properties have not been thoroughly investigated. 
ROUTE OF EXPOSURE 
Skin Contact: May cause skin irritation. 
Skin Absorption: May be harmful if absorbed through the skin. 
Eye Contact: May cause eye irritation. 
Inhalation: May be harmful if inhaled. Material may be 
irritating to mucous membranes and upper respiratory tract. 
Ingestion: May be harmful if swallowed. 
CONDITIONS AGGRAVATED BY EXPOSURE 
Reported to excite NMDA receptors in the brain. The 
toxicological properties have not been thoroughly investigated. 
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Contact a licensed professional waste disposal service to dispose 
of this material. Dissolve or mix the material with a combustible 
solvent and burn in a chemical incinerator equipped with an 
afterburner and scrubber. Observe all federal, state, and local 
FLUKA - 65831 www.sigma-aldrich.com Page 3
environmental regulations. 
14 - Transport Information 
RID/ADR 
Non-hazardous for road transport. 
IMDG 
Non-hazardous for sea transport. 
IATA 
Non-hazardous for air transport. 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
S-PHRASES: 22 24/25 
Do not breathe dust. Avoid contact with skin and eyes. 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
FLUKA - 65831 www.sigma-aldrich.com Page 4