SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 09/OCT/2003 
Date Updated: 15/MAY/2002 
Version 1.2 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name PROPYL GALLATE, 97% 
Product Number P53306 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
PROPYL GALLATE 121-79-9 204-498-2 
Formula C10H12O5 
Molecular Weight 212.2 AMU 
Synonyms Benzoic acid, 3,4,5-trihydroxy-, propyl ester, 
NIPA 49,Nipagallin P,Progallin P, 
Propylester kyseliny gallove (Czech), 
n-Propyl ester of 3,4,5-trihydroxybenzoic acid, 
Propyl gallate,n-Propyl gallate,Propyl 3,4, 
5-trihydroxybenzoate,n-Propyl 3,4, 
5-trihydroxybenzoate,Tenox PG,3,4, 
5-Trihydroxybenzene-1-propylcarboxylate,3,4, 
5-Trihydroxybenzoic acid n-propyl ester 
3 - Hazards Identification 
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT 
Harmful if swallowed. May cause sensitization by skin contact. 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If not breathing give 
artificial respiration. If breathing is difficult, give oxygen. 
AFTER SKIN CONTACT 
In case of contact, immediately wash skin with soap and copious 
amounts of water. 
AFTER EYE CONTACT 
In case of contact, immediately flush eyes with copious amounts 
of water for at least 15 minutes. 
AFTER INGESTION 
If swallowed, do not induce vomiting; call a physician 
immediately.
5 - Fire Fighting Measures 
EXPLOSION DATA 
Dust Potential: This material, like most materials in powder 
form, is capable of creating a dust explosion. 
EXTINGUISHING MEDIA 
Suitable: Carbon dioxide, dry chemical powder, or appropriate 
foam. Water spray. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear self-contained breathing apparatus, rubber boots, and heavy 
rubber gloves. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Avoid inhalation. Do not get in 
eyes, on skin, on clothing. Avoid prolonged or repeated exposure. 
STORAGE 
Conditions of Storage: Keep tightly closed. Store in a cool dry 
place. 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Safety shower and eye bath. Mechanical exhaust required. Use only 
in a chemical fume hood. 
GENERAL HYGIENE MEASURES 
Wash contaminated clothing before reuse. Wash thoroughly after 
handling. 
PERSONAL PROTECTIVE EQUIPMENT 
Respiratory Protection: Government approved respirator. 
Hand Protection: Rubber gloves. 
Eye Protection: Chemical safety goggles. 
9 - Physical and Chemical Properties 
Appearance Physical State: Solid 
Color: Faintly beige 
Form: Crystals 
Property Value At Temperature or Pressure 
pH 5.7 - 6.3 
BP/BP Range N/A 
MP/MP Range 148 - 150 °C 
Flash Point 86.1 °C Method: closed cup 
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Flammability N/A 
Autoignition Temp 438 °C 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
SG/Density 1.21 g/cm3 
Partition Coefficient Log Kow: 1.51 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. 330 °C 
Solvent Content N/A 
Water Content N/A 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility Solubility in Water:Soluble. 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Materials to Avoid: Strong oxidizing agents, Strong acids, Strong 
bases, Strong reducing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: LW8400000 
ACUTE TOXICITY 
LD50 
Oral 
Rat 
3,000 mg/kg 
LD50 
Oral 
Mouse 
2,000 mg/kg 
LD50 
Oral 
Rat 
2100 mg/kg 
LD50 
Intraperitoneal 
Rat 
380 MG/KG 
Remarks: Behavioral:Convulsions or effect on seizure threshold. 
Lungs, Thorax, or Respiration:Dyspnea. Lungs, Thorax, or 
Respiration:Other changes. 
LD50 
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Oral 
Mouse 
1700 mg/kg 
LD50 
Oral 
Rabbit 
2750 mg/kg 
LD50 
Oral 
Pig 
> 6000 mg/kg 
Remarks: Kidney, Ureter, Bladder:Other changes. 
LD50 
Oral 
Hamster 
2480 mg/kg 
SENSITIZATION 
Skin: May cause allergic skin reaction. 
ROUTE OF EXPOSURE 
Skin Absorption: May be harmful if absorbed through the skin. 
Inhalation: Material is irritating to mucous membranes and upper 
respiratory tract. May be harmful if inhaled. 
Ingestion: Harmful if swallowed. 
Multiple Routes: Causes eye and skin irritation. 
CHRONIC EXPOSURE - CARCINOGEN 
Mouse 
Route of Application: Oral 
Exposure Time: 2Y 
Result: Tumorigenic:Equivocal tumorigenic agent by RTECS 
criteria. Lungs, Thorax, or Respiration:Tumors. Liver:Tumors. 
CHRONIC EXPOSURE - MUTAGEN 
Mouse 
900 MG/KG 
Intraperitoneal 
72H 
Micronucleus test 
Mouse 
12500 UG/L 
Cell Type: lymphocyte 
Mutation in mammalian somatic cells. 
Hamster 
5 MG/L 
Cell Type: ovary 
Cytogenetic analysis 
Hamster 
40 MG/L 
Cell Type: fibroblast 
Cytogenetic analysis 
Hamster 
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10 MG/L 
Cell Type: lung 
Cytogenetic analysis 
Hamster 
5 MG/L 
Cell Type: ovary 
Sister chromatid exchange 
CHRONIC EXPOSURE - TERATOGEN 
Species: Rat 
Dose: 45 GM/KG 
Route of Application: Oral 
Exposure Time: (1-22D PREG) 
Result: Specific Developmental Abnormalities: Musculoskeletal 
system. 
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD 
Species: Rat 
Dose: 19 GM/KG 
Route of Application: Oral 
Exposure Time: (1-22D PREG) 
Result: Effects on Newborn: Viability index (e.g., # alive at 
day 4 per # born alive). 
Species: Rat 
Dose: 2500 MG/KG 
Route of Application: Oral 
Exposure Time: (1-22D PREG) 
Result: Effects on Fertility: Post-implantation mortality (e.g., 
dead and/or resorbed implants per total number of implants). 
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Observe all federal, state, and local environmental regulations. 
14 - Transport Information 
RID/ADR 
Non-hazardous for road transport. 
IMDG 
Non-hazardous for sea transport. 
IATA 
Non-hazardous for air transport. 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
ANNEX I INDEX NUMBER: 607-198-00-3 
INDICATION OF DANGER: Xn 
Harmful. 
R-PHRASES: 22 43 
Harmful if swallowed. May cause sensitization by skin contact. 
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S-PHRASES: 24 37 
Avoid contact with skin. Wear suitable gloves. 
SWITZERLAND 
SWISS POISON CLASS: 4 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
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