Conforms to 93/112/EC and ISO 11014-1 Material Safety Data Sheet Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate 2274 1900145 0027735 CALL CHEMTREC: 800.424.9300 OUTSIDE US: 202.483.7616 11/4/2002 11/14/2002 Product name Supplier Manufacturer Product No. MSDS# Validation Date Print Date In Case of Emergency Section 1. Chemical Product and Company Identification Responsible Name Pierce Administration Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. Sulfo-LC-NHS-ASA, Sulfosuccinimidyl (4-Azidosalicylamido) Hexanoate Chemical name Eng In USA: In Europe: Pierce Perbio Science P.O. Box 117 Industriezone III Rockford, IL 61105 Industrielaan 27 USA 9320 Erembodegem-Aalst 815.968.0747 or Belgium 1.800.874.3723 Tel:+32 53 83 44 04 Fax:+32 53 83 76 38 Pierce Biotechnology P.O. Box 117 Rockford, IL 61105 USA 815.968.0747 or 1.800.874.3723 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate 98-100 Not available. -- Not controlled under dsd (Europe). Ingredient Name EC Number CAS No. R-Phrases Substance/Preparation Substance % Symbol : Section 2. Composition, Information on Ingredients Physical/chemical hazards Human health hazards Environmental hazards Not applicable. Not applicable. Not applicable. Absorbed through skin. Eye contact. Inhalation. Ingestion. Emergency Overview Medical Conditions Aggravated by Overexposure: Repeated or prolonged exposure is not known to aggravate medical condition. Not available. Overexposure /Signs/Symptoms Section 3. Hazards Identification Routes of Entry Potential Acute Health Effects Carcinogenic Effects Data See Toxicological Information (section 11) No specific information is available in our database regarding the acute toxic effects of this material for humans. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available. TERATOGENIC EFFECTS: Not available. Review the most current and approved institutional guideline, protocol, standard operating procedure(s) and MSDS(s) for the proper handling of institutional materials/equipment associated with the use of this product. WARNING! CAUSES DAMAGE TO THE FOLLOWING ORGANS: SKIN, EYES. Classification Not controlled under dsd (Europe). United States Europe Continued on Next Page Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Page: 2/6 Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Skin Contact Ingestion Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention. In case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Not available. Not available. Not available. Skin Contact Not available. Eye Contact Inhalation Aggravating conditions Repeated or prolonged exposure is not known to aggravate medical condition. First-Aid Measures If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Notes to Physician Not available. Not available. Protection of first-aiders Ingestion Effects and symptoms Inhalation Eye Contact Section 4. First Aid Measures Notice to Reader Get immediate medical attention. Hazardous thermal (de)composition products Not available. May be combustible at high temperature. Not available. SMALL FIRE: Use DRY chemical powder. LARGE FIRE: Use water spray, fog or foam. Do not use water jet. Not available. Section 5. Fire Fighting Measures Flammability of the Product Flash Points Fire Hazards in Presence of Various Substances Fire Fighting Media and Instructions Be sure to use an approved/certified respirator or equivalent. Protective Clothing (Fire) Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 6. Accidental Release Measures Small Spill and Leak Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements. Environmental Precautions and Clean-up Methods Personal precautions Safety glasses. Lab coat. Keep container tightly closed. Keep container in a cool, well-ventilated area. Avoid breathing dust. Section 7. Handling and Storage Handling Storage Suitable / Not suitable Packaging materials Use original container. Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. Continued on Next Page Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Page: 3/6 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Not available. Germany 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Not available. Netherlands 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Not available. France 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Not available. Norway 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Not available. Denmark 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Not available. Sweden 1) Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Not available. United States Ingredient Name Occupational Exposure Limits Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Section 8. Exposure Controls/Personal Protection Exposure Limit Values Personal Protection Eyes Body Hands Protective Clothing (Pictograms) Gloves. Lab coat. Splash goggles. Respiratory Respirator is not needed under normal and intended conditions of use, if exposures are kept below established limits. Solid. Not available. Very slightly soluble in cold water, hot water. Not available. Not available. Not available. Not available. Physical State and Appearance Molecular Weight Dispersion Properties Solubility Odor Taste Color Section 9. Physical and Chemical Properties Continued on Next Page Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Page: 4/6 The product is stable. Reactive with oxidizing agents, metals, acids, moisture. Will not occur. Not available. Section 10. Stability and Reactivity Stability and Reactivity Conditions to avoid Materials to avoid Hazardous Polymerization Hazardous Decomposition Products Not available. LD50: Not available. LC50: Not available. No specific information is available in our database regarding the other toxic effects of this material for humans. Causes damage to the following organs: skin, eyes. Not available. Not available. Not available. Section 11. Toxicological Information Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Special Remarks on Toxicity to Animals Special Remarks on Chronic Effects on Humans Special Remarks on Other Toxic Effects on Humans Ecotoxicity Not available. Mobility Germany water class Not available. Not available. Not available. Persistence/degradability Bioaccumulative potential VCI WGK: No products were found. Section 12. Ecological Information Waste must be disposed of in accordance with federal, state and local environmental control regulations. Not available. Waste Information Waste Stream Section 13. Disposal Considerations Consult your local or regional authorities. Contact the supplier for all information regarding the proper transportation method for this material. Section 14. Transport Information Continued on Next Page Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Page: 5/6 U.S. Federal Regulations No products were found. Irritating substance. HCS Classification Section 15. Regulatory Information California prop. 65: No products were found. TSCA: No products were found. Clean Water Act (CWA) 307: No products were found. Clean Water Act (CWA) 311: No products were found. Clean air act (CAA) 112 accidental release prevention: No products were found. Clean air act (CAA) 112 regulated flammable substances: No products were found. Clean air act (CAA) 112 regulated toxic substances: No products were found. State Regulations No products were found. No products were found. WHMIS (Canada) Not controlled under WHMIS (Canada). This product is not classified according to the EU regulations. DSCL (EEC) International Regulations Not available. EINECS International Lists SARA 302/304/311/312 extremely hazardous substances: No products were found. SARA 302/304 emergency planning and notification: No products were found. SARA 302/304/311/312 hazardous chemicals: No products were found. SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found. SARA 313 toxic chemical notification and release reporting: No products were found. This product is not classified according to the EU regulations. Label Requirements (Europe) 1 Version 0.01 Date of Previous Issue No Previous Validation Not available. Section 16. Other Information References Validated by Pierce Administration on 11/4/2002. Verified by Pierce Administration. Printed 11/14/2002. Notice to Reader Hazardous Material Information System (U.S.A.) 1 1 0 a 0 1 1 * National Fire Protection Association (U.S.A.) Health Specific Hazard Reactivity Fire Hazard Health Fire Hazard Reactivity Personal Protection History of Document Changes Any information changes since last document version are marked with a triangle symbol. Not applicable. Full text of R-Phrases referenced under headings 2 and 3: Intended Use Refer to the instruction booklet for proper and intended use. Otherwise, contact supplier for specific applications. Continued on Next Page Sulfo-LC-NHS-ASA, Sulfosuccinimidyl(4-Azidosalicylamido) Hexanoate Page: 6/6 To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein. Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.