SIGMA CHEMICAL CO -- NICOTINIC ACID CELL CULTURE TESTED, N0761 ======================================================= MSDS Safety Information ======================================================= FSC: 6550 MSDS Date: 01/01/1999 MSDS Num: CJXHX LIIN: 00N093179 Product ID: NICOTINIC ACID CELL CULTURE TESTED, N0761 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST Box: 14508 City: ST LOUIS MO 63178 Phone: 314-771-5765 ======================================================= Item Description Information ======================================================= ======================================================= Ingredients ======================================================= Cas: 98-92-0 RTECS #: QS3675000 Name: NICOTINAMIDE; (NICOTINIC ACID) Percent by Wt: 100. Other REC Limits: N/K (FP N) OSHA PEL: N/K (FP N) OSHA STEL: N/K (FP N) ACGIH TLV: N/K (FP N) ACGIH STEL: N/K (FP N) ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE TOXICOLOGICAL INFORMATION. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: MAY BE HARMFUL BY INHALATION, INGESTION/SKIN ABSORPTION. CAUSES EYE & SKIN IRRITATION. MATERIAL IS IRRITATING TO MUCOUS MEMBRANES & UPPER RESPIRATORY TRACT. MAY PRODUCE REVERSIBLE LIVER DAMAGE. TO THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, & TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. OVEREXPOSURE TO NICOTINIC ACID CAN PRODUCE POWERFUL PERIPHERAL VASOD ILATING ACTION. THIS EFFECT IS SEEN AS INTENSE FLUSHING OF SKIN & OCCURS ABOUT 15 TO 60 MINUTES AFTER EXPOSURE. IT IS ACCOMPANIED BY SENSE OF WARMTH, TINGLING, & ITCHING OF SKIN & SUBSIDES GRADUALLY O VER A PERIOD OF 15 TO 30 MINUTES. Signs And Symptions Of Overexposure: SEE HEALTH HAZARDS. First Aid: EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE AR TIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE REUSE. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL S ITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. AVOID CONTACT WITH EYES, SKIN AND CLOTHING. KEEP TIGHTLY CLOSED. STORE IN A COOL DRY PLACE. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: NIOSH APPROVED RESPIRATOR. Ventilation: MECHANICAL EXHAUST REQUIRED. Protective Gloves: COMPATIBLE CHEMICAL-RESISTANT GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: EYEWASH AND DELUGE SHOWER MEETING ANSI DESIGN CRITERIA (FP N). Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. Supplemental Safety and Health: MF: C*6H*5NO*2. EC NUMBER: 200-441-0. ======================================================= Physical/Chemical Properties ======================================================= Melt/Freeze Pt: >236.C, 456.8F M.P/F.P Text: 236C TO 239C Appearance and Odor: WHITE POWDER. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Materials To Avoid: STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: TOXIC FUMES OF CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: RTECS # QT0525000, NICOTINIC ACID. TOXICITY DATA: ORL-RAT LD50: 7 GM/KG; NIIRDN 6, 544, 1982. IPR-RAT LD50: 730 MG/KG; OYYAA2 14, 741, 1977. SCU-RAT LD50: 5 GM/KG; NIIRDN 6, 544, 1982. ORL-MUS LD50: 3 720 MG/KG; OYYAA2 7, 149, 1973. IPR-MUS LD50: 358 MG/KG; OYYAA2 14, 741, 1977. SCU-MUS LD50: 3500 MG/KG; OYYAA2 14, 741, 1977. IVN-MUS LD50: 5 GM/KG; THERAP 26, 831, 1971. UNR-MUS LD50: 4 GM/KG; BAXXD U #2041937. ORL-RBT LD50: 4550 MG/KG; OYYAA2 14, 741, 1977. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORM ATION. ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: EUROPEAN INFORMATION: IRRITANT. R 36/37/38: IRRITATING TO EYES, RESPIRATORY SYSTEM AND SKIN. S 26: IN CASE OF CONTACT WITH EYES, RINSE IMMEDIATELY WITH PLENTY OF WATER AND SEEK MEDICAL ADVICE. S 36: W EAR SUITABLE PROTECTIVE CLOTHING. REVIEWS, STANDARDS, AND REGULATIONS: OEL=MAK. OEL-RUSSIA: STEL 1 MG/M3 JAN 1993. NOHS 1974: HZD 81908; NIS 10; TNF 1815; NOS 19; TNE 13494. NOES 1983: HZD 81908; NIS 15; TNF 3028; NOS 46; TNE 61057; TFE 26152. EPA TSCA SECTION 8 (B) CHEMICAL INVENTORY. EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998. ======================================================= HAZCOM Label ======================================================= Product ID: NICOTINIC ACID CELL CULTURE TESTED, N0761 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 12/15/1999 Status Code: A Origination Code: F Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Moderate Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE: MAY BE HARMFUL BY INHAL, INGEST/SKIN ABSORPTION. CAUSES EYE & SKIN IRRIT. MATL IS IRRITATING TO MUC MEMBS & UPPER RESP TRACT. MAY PRODUCE REVERSIBLE LIVER DMG. CHRONIC: NONE SPECIFIED BY MANUF ACTURER (FP N). TO THE BEST OF MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, & TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. OVEREXPOSURE TO NICOTINIC ACID CAN PRODUCE POWERFUL PERIPHERAL VASODILATING ACTION. THIS EFFECT IS SEEN AS INTENSE FLUSHING OF SKIN & OCCURS ABOUT 15 TO 60 MINUTES AFTER EXPOSURE. IT IS ACCOMPANIED BY SENSE OF WARMTH, TINGLING, & ITCHING OF SKIN & SUBS IDES GRADUALLY OVER A PERIOD OF 15 TO 30 MINUTES. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.