======================================================= MSDS Safety Information ======================================================= NAME: OXIDIZER ======================================================= Material Safety Data Sheet Oxidizer-0.02M Iodine in THF / Pyridine / Water ACC# 91507 Section 1 - Chemical Product and Company Identification MSDS Name: Oxidizer-0.02M Iodine in THF / Pyridine / Water Catalog Numbers: BP3142, BP3142-4, NC9223544, NC9705580 Synonyms: None. Company Identification: Fisher Scientific 1 Reagent Lane Fair Lawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887 Section 2 - Composition, Information on Ingredients CAS# Chemical Name Percent EINECS/ELINCS 109-99-9 Tetrahydrofuran 89-91 203-726-8 7732-18-5 Water 9-10 231-791-2 110-86-1 Pyridine <1.0 203-809-9 7553-56-2 Iodine <1.0 231-442-4 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: colorless liquid. Flash Point: -14 deg C. Danger! Extremely flammable liquid and vapor. Vapor may cause flash fire. Causes severe eye irritation and possible injury. Causes respiratory tract irritation. Uninhibited material, or material from which the inhibitor has been removed or reacted, may form explosive peroxides. May be absorbed through intact skin. Causes skin irritation. May be harmful if swallowed. May cause central nervous system depression. May cause lung damage. May cause liver and kidney damage. Target Organs: Kidneys, central nervous system, liver, lungs. Potential Health Effects Eye: Contact with eyes may cause severe irritation, and possible eye burns. Vapors may cause eye irritation. Skin: Causes skin irritation. May be absorbed through the skin. If absorbed, causes symptoms similar to those of inhalation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause central nervous system depression. Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Vapors may cause dizziness or suffocation. Inhalation may cause coughing, difficulty breathing and loss of consciousness. Causes irritation of the mucous membrane and upper respiratory tract. Chronic: Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause defatting and dermatitis. May cause liver and kidney damage. May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. May cause lung damage. Narcotic in high concentrations. Section 4 - First Aid Measures Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid imme diately. Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. Notes to Physician: Treat symptomatically and supportively. Persons with kidney disease, chronic respiratory disease, liver disease, or skin disease may be at increased risk from exposure to this substance. Section 5 - Fire Fighting Measures General Information: Persons with kidney disease, chronic respiratory disease, liver disease, or skin disease may be at increased risk from exposure to this substance. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Use water spray to keep fire-exposed containers cool. Extremely flammable liquid and vapor. Forms peroxides of unknown stability. Containers may explode in the heat of a fire. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Will be easily ignited by heat, sparks or flame. Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. For large fires, use water spray, fog or alcohol-resistant foam. Do NOT use straight streams of water. Contact professional fire-fighters immediately. Cool containers with flooding quantities of water until well after fire is out. Flash Point: -14 deg C ( 6.80 deg F) Autoignition Temperature: 321 deg C ( 609.80 deg F) Explosion Limits, Lower:1.8 vol % Upper: 11.8 vol % NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 1 Section 6 - Accidental Release Measures General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Use water spray to dilute spill to a non-flammable mixture. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool. Isolate area and deny entry. A vapor suppressing foam may be used to reduce vapors. Section 7 - Handling and Storage Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Do not ingest or inhale. Prevent build up of vapors to explosive concentration. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool place in the original container and protect from sunlight. Keep under a nitrogen blanket. Keep from contact with oxidizing materials. Flammables-area. Regularly check inhibitor levels to maintain peroxide levels below 1%. Store protected from moisture. Section 8 - Exposure Controls, Personal Protection Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits Chemical Name ACGIH NIOSH OSHA - Final PELs Tetrahydrofuran 50 ppm TWA; 100 ppm STEL; Skin - potential significant contribution to overall exposure by the cutaneous r oute 200 ppm TWA; 590 mg/m3 TWA 2000 ppm IDLH 200 ppm TWA; 590 mg/m3 TWA Water none listed none listed none listed Pyridine 1 ppm TWA 5 ppm TWA; 15 mg/m3 TWA 1000 ppm IDLH 5 ppm TWA; 15 mg/m3 TWA Iodine 0.1 ppm Ceiling 2 ppm IDLH 0.1 ppm Ceiling; 1 mg/m3 Ceiling OSHA Vacated PELs: Tetrahydrofuran: 200 ppm TWA; 590 mg/m3 TWA Water: No OSHA Vacated PELs are listed for this chemical. Pyridine: 5 ppm TWA; 15 mg/m3 TWA Iodine: No OSHA Vacated PELs are listed for this chemical. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Section 9 - Physical and Chemical Properties Physical State: liquid Appearance: colorless Odor: ethereal odor - fruity odor pH: Not available. Vapor Pressure: 160 mm Hg @25C Vapor Density: 2.5 (air = 1) Evaporation Rate:>1 (Butyl Acetate = 1) Viscosity: 0.48 cP @ 20C Boiling Point: 65.4 deg C Freezing/Melting Point:-65 deg C Decomposition Temperature:Not available. Solubility: Miscible. Specific Gravity/Density:0.89 Molecular Formula:C4H8O Molecular Weight:72.0554 Section 10 - Stability and Reactivity Chemical Stability: Prolonged exposure to air and sunlight may form unstable peroxides. Explosive peroxides may form on concentration. Peroxides can be detonated by friction, impact, or heating. Peroxide formation may occur in containers that have been opened and remain in storage. Normally stable; however, on long term storage, materials containing similar functional groups form peroxides of unknown stability. Conditions to Avoid: Normally stable; however, on long term storage, materials containing similar functional groups form peroxides of unknown stability., light, moisture, excess heat. Incompatibilities with Other Materials: Oxidizing agents, acids, bases, oxygen, caustics (e.g. ammonia, ammonium hydroxide, calcium hydroxide, potassium hydroxide, sodium hydroxide), bromine, metal halides, moisture, lithium tetrahydroaluminate, borane, 2-aminophenol + potassium dioxide, calcium hydride + heat, sodium aluminum hydride, sodium tetrahydroaluminate, 2-aminophenol. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: May occur. Section 11 - Toxicological Information RTECS#: CAS# 109-99-9: LU5950000 CAS# 7732-18-5: ZC0110000 CAS# 110-86-1: UR8400000 CAS# 7553-56-2: NN1575000 LD50/LC50: CAS# 109-99-9: Inhalation, rat: LC50 = 21000 ppm/3H; Oral, rat: LD50 = 1650 mg/kg; . CAS# 7732-18-5: Oral, rat: LD50 = >90 mL/kg; . CAS# 110-86-1: Dermal, guinea pig: LD50 = 1 gm/kg; Draize test, rabbit, skin: 500 mg/24H Mild; Inhalation, rat: LC50 = 28500 mg/m3/1H; Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 891 mg/kg; Skin, rabbit: LD50 = 1121 mg/kg; . CAS# 7553-56-2: Oral, mouse: LD50 = 22 gm/kg; Oral, mouse: LD50 = 1000 mg/kg; Oral, rabbit: LD50 = 10 gm/kg; Oral, rat: LD50 = 14 gm/kg; . Carcinogenicity: CAS# 109-99-9: * ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans * California: Not listed. * NTP: Not listed. * IARC: Not listed. CAS# 7732-18-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65. CAS# 110-86-1: * ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans * California: carcinogen, initial date 5/17/02 * NTP: Not listed. * IARC: Not listed. CAS# 7553-56-2: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: No information found Teratogenicity: Inhalation, rat: TCLo = 5000 ppm/6H (female 6-19 day(s) after conception) Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus). Reproductive Effects: Inhalation, mouse: TClo = 1800 ppm/6H (female 6-17 day(s) after conception) Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants). Mutagenicity: Mutation in Microorganisms: Escherichia coli = 1 umol/L. Neurotoxicity: No information found Other Studies: Section 12 - Ecological Information Ecotoxicity: Fish: Fathead Minnow: LC50 = 2160 mg/L; 96 Hr; Flow through bioassay (pH 7.5) Tetrahydrofuran is not expected to adsorb to suspended matter in the water based on its measured Koc values. This compound should volatilize from water surfaces. An estimated BCF value of 1 suggests that tetrahydrofuran will not bioconcentrate in aquatic organisms. Environmental: If released to the atmosphere, tetrahydrofuran will exist solely in the vapor phase and is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals and nitrate radicals with half-lives of about 1 and 3 days, respectively. Measured Koc values of 23 and 18 indicate that tetrahydrofuran will have very high mobility in soil. Physical: No information available. Other: No information available. Section 13 - Disposal Considerations Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification. RCRA P-Series: None listed. RCRA U-Series: CAS# 109-99-9: waste number U213 (Ignitable waste). CAS# 110-86-1: waste number U196. Section 14 - Transport Information US DOT Canada TDG Shipping Name: FLAMMABLE LIQUIDS, N.O.S. (Tetrahydrofuran, Pyridine) FLAMMABLE LIQUIDS, N.O.S. (Tetrahydrofuran, Pyridine) Hazard Class: 3 3 UN Number: UN1993 UN1993 Packing Group: II II Section 15 - Regulatory Information US FEDERAL TSCA CAS# 109-99-9 is listed on the TSCA inventory. CAS# 7732-18-5 is listed on the TSCA inventory. CAS# 110-86-1 is listed on the TSCA inventory. CAS# 7553-56-2 is listed on the TSCA inventory. Health & Safety Reporting List CAS# 110-86-1: Effective 10/4/82, Sunset 10/4/92 Chemical Test Rules CAS# 109-99-9: 40 CFR 799.5000; 40 CFR 799.5115 Section 12b CAS# 109-99-9: Section 4 TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs CAS# 109-99-9: 1000 lb final RQ; 454 kg final RQ CAS# 110-86-1: 1000 lb final RQ; 454 kg final RQ SARA Section 302 Extremely Hazardous Substances None of the chemicals in this product have a TPQ. SARA Codes CAS # 109-99-9: immediate, fire, reactive. CAS # 110-86-1: immediate, delayed, fire. CAS # 7553-56-2: immediate, delayed, fire. Section 313 This material contains Pyridine (CAS# 110-86-1, <1.0%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE CAS# 109-99-9 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. CAS# 7732-18-5 is not present on state lists from CA, PA, MN, MA, FL, or NJ. CAS# 110-86-1 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. CAS# 7553-56-2 can be found on the following state right to know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts. California Prop 65 WARNING: This product contains Pyridine, a chemical known to the state of California to cause cancer. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI F Risk Phrases: R 11 Highly flammable. R 19 May form explosive peroxides. R 36/37 Irritating to eyes and respiratory system. Safety Phrases: S 16 Keep away from sources of ignition - No smoking. S 29 Do not empty into drains. S 33 Take precautionary measures against static discharges. WGK (Water Danger/Protection) CAS# 109-99-9: 1 CAS# 7732-18-5: No information available. CAS# 110-86-1: 2 CAS# 7553-56-2: 1 Canada - DSL/NDSL CAS# 109-99-9 is listed on Canada's DSL List. CAS# 7732-18-5 is listed on Canada's DSL List. CAS# 110-86-1 is listed on Canada's DSL List. CAS# 7553-56-2 is listed on Canada's DSL List. Canada - WHMIS This product has a WHMIS classification of D2B, B2. This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations. Canadian Ingredient Disclosure List CAS# 109-99-9 is listed on the Canadian Ingredient Disclosure List. CAS# 110-86-1 is listed on the Canadian Ingredient Disclosure List. CAS# 7553-56-2 is listed on the Canadian Ingredient Disclosure List. Section 16 - Additional Information MSDS Creation Date: 4/24/2000 Revision #7 Date: 3/16/2007 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.