SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 09/OCT/2003 
Date Updated: 15/SEP/2003 
Version 1.1 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name PACLITAXEL, 95% 
Product Number 417017 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
PACLITAXEL FROM TAXUS BREVIFOLIA 33069-62-4 None 
Ingredient Name Percent CAS # EC no Annex I 
Index Number 
The hazards identified None None None 
with this product are 
those associated with 
the residual solvents 
that are used in the 
manufacturing process. 
METHANOL <= 4 67-56-1 200-659-6 603-001-00-X 
Symbols: F T 
R-Phrases: 11 23/24/25 39/23/24/25 
Highly flammable. Toxic by inhalation, in contact with skin and if 
swallowed. Toxic: danger of very serious irreversible effects 
through inhalation, in contact with skin and if swallowed. 
ISOPROPANOL <= 4 67-63-0 200-661-7 603-117-00-0 
Symbols: F Xi 
R-Phrases: 11 36 67 
Highly flammable. Irritating to eyes. Vapors may cause drowsiness 
and dizziness. 
ETHYL ALCOHOL, <= 1 64-17-5 200-578-6 603-002-00-5 
NON-DENATURED 
Symbols: F 
R-Phrases: 11 
Highly flammable. 
Formula C47H51NO14 
Molecular Weight 853.93 AMU 
Synonyms BMS 181339-01,NSC-125973,Paclitaxel,Taxol,Taxol A 
3 - Hazards Identification 
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful by inhalation, in contact with skin and if swallowed. 
Harmful: danger of serious damage to health by prolonged exposure 
through inhalation in contact with skin, and if swallowed. 
Irritating to respiratory system and skin. Risk of serious damage 
to eyes. May cause sensitization by inhalation and skin contact. 
Possible risk of impaired fertility. Possible risk of irreversible 
effects. 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If not breathing give 
artificial respiration. If breathing is difficult, give oxygen. 
AFTER SKIN CONTACT 
In case of skin contact, flush with copious amounts of water for 
at least 15 minutes. Remove contaminated clothing and shoes. 
Call a physician. 
AFTER EYE CONTACT 
In case of contact with eyes, flush with copious amounts of 
water for at least 15 minutes. Assure adequate flushing by 
separating the eyelids with fingers. Call a physician. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician immediately. 
5 - Fire Fighting Measures 
EXTINGUISHING MEDIA 
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam. 
SPECIAL RISKS 
Specific Hazard(s): Emits toxic fumes under fire conditions. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL 
Evacuate area. 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear self-contained breathing apparatus, rubber boots, and heavy 
rubber gloves. Wear disposable coveralls and discard them after 
use. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Do not breathe dust. Do not get in 
eyes, on skin, on clothing. Avoid prolonged or repeated 
ALDRICH - 417017 www.sigma-aldrich.com Page 2
exposure. Do not use if skin is cut or scratched. Wash 
thoroughly after handling. 
STORAGE 
Conditions of Storage: Keep tightly closed. Store in a cool dry 
place. 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Use only in a chemical fume hood. Safety shower and eye bath. 
Mechanical exhaust required. 
GENERAL HYGIENE MEASURES 
Wash contaminated clothing before reuse. Wash thoroughly after 
handling. 
PERSONAL PROTECTIVE EQUIPMENT 
Respiratory Protection: Government approved respirator. 
Hand Protection: Compatible chemical-resistant gloves. 
Eye Protection: Chemical safety goggles. 
9 - Physical and Chemical Properties 
Appearance Physical State: Solid 
Property Value At Temperature or Pressure 
pH 3 - 8 
BP/BP Range N/A 
MP/MP Range 213 °C 
Flash Point N/A 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
SG/Density 0.2 g/cm3 
Partition Coefficient Log Kow: > 99 
Viscosity N/A 
Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. > 100 °C 
Solvent Content N/A 
Water Content N/A 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility Solubility in Water:Insoluble. 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Materials to Avoid: Strong oxidizing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, 
Nitrogen oxides. 
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HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: DA8340700 
ACUTE TOXICITY 
LDLO 
Intravenous 
Woman 
4,995 mg/kg 
LD50 
Intraperitoneal 
Rat 
32,530 mg/kg 
LD50 
Intraperitoneal 
Mouse 
128 mg/kg 
LD50 
Intravenous 
Mouse 
12 mg/kg 
LDLO 
Intravenous 
Woman 
4995 MG/KG 
3H-C 
Remarks: Cardiac:Cardiomyopathy including infarction. 
Blood:Leukopenia. Blood:Thrombocytopenia. 
LD50 
Intraperitoneal 
Rat 
32530 UG/KG 
Remarks: Behavioral:Somnolence (general depressed activity). 
Lungs, Thorax, or Respiration:Dyspnea. Nutritional and Gross 
Metabolic:Weight loss or decreased weight gain. 
LD50 
Intraperitoneal 
Mouse 
128 MG/KG 
Remarks: Skin and Appendages: Other: Hair. Nutritional and Gross 
Metabolic:Weight loss or decreased weight gain. 
LD50 
Intravenous 
Mouse 
12 MG/KG 
Remarks: Behavioral:Somnolence (general depressed activity). 
Behavioral:Ataxia. Lungs, Thorax, or Respiration:Respiratory 
depression. 
SENSITIZATION 
Respiratory: May cause allergic respiratory reaction. 
Skin: May cause allergic skin reaction. 
SIGNS AND SYMPTOMS OF EXPOSURE 
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Exposure can cause: Damage to the liver. Alopecia. Nausea, 
headache, and vomiting. Damage to the kidneys. Can cause severe 
cardiotoxicity and bone marrow suppression. 
ROUTE OF EXPOSURE 
Skin Contact: Causes skin irritation. 
Skin Absorption: Harmful if absorbed through skin. 
Eye Contact: Causes severe eye irritation. 
Inhalation: Material is irritating to mucous membranes and upper 
respiratory tract. Harmful if inhaled. 
Ingestion: Harmful if swallowed. 
TARGET ORGAN INFORMATION 
Cardiovascular system. Heart. Nerves. Eyes. Kidneys. Liver. Bone 
marrow. Lungs. Blood. Skin. G.I. System. 
CHRONIC EXPOSURE - MUTAGEN 
Result: Laboratory experiments have shown mutagenic effects. 
Mouse 
20 MG/KG 
Subcutaneous 
Micronucleus test 
Hamster 
80 UG/L 
Cell Type: lung 
Cytogenetic analysis 
CHRONIC EXPOSURE - TERATOGEN 
Species: Rat 
Dose: 6600 UG/KG 
Route of Application: Intravenous 
Exposure Time: (7-17D PREG) 
Result: Specific Developmental Abnormalities: Musculoskeletal 
system. Effects on Newborn: Delayed effects. 
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD 
Result: Overexposure may cause reproductive disorder(s) based on 
tests with laboratory animals. 
Species: Rat 
Dose: 84 MG/KG 
Route of Application: Intravenous 
Exposure Time: (9W MALE/2W PRE/1-7D PREG) 
Result: Maternal Effects: Other effects. Effects on Fertility: 
Pre-implantation mortality (e.g., reduction in number of 
implants per female; total number of implants per corpora 
lutea). Effects on Embryo or Fetus: Extra embryonic structures 
(e.g., placenta, umbilical cord). 
Species: Rat 
Dose: 26 MG/KG 
Route of Application: Intravenous 
Exposure Time: (17-21D PREG/21D POST) 
Result: Effects on Newborn: Growth statistics (e.g., reduced 
weight gain). Effects on Newborn: Behavioral. Effects on 
Newborn: Physical. 
12 - Ecological Information 
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No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Contact a licensed professional waste disposal service to dispose 
of this material. Dissolve or mix the material with a combustible 
solvent and burn in a chemical incinerator equipped with an 
afterburner and scrubber. Observe all federal, state, and local 
environmental regulations. 
14 - Transport Information 
RID/ADR 
Non-hazardous for road transport. 
IMDG 
Non-hazardous for sea transport. 
IATA 
Non-hazardous for air transport. 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
INDICATION OF DANGER: Xn 
Harmful. 
R-PHRASES: 20/21/22 48/20/21/22 37/38 41 42/43 62 68 
Harmful by inhalation, in contact with skin and if swallowed. 
Harmful: danger of serious damage to health by prolonged 
exposure through inhalation in contact with skin, and if 
swallowed. Irritating to respiratory system and skin. Risk of 
serious damage to eyes. May cause sensitization by inhalation 
and skin contact. Possible risk of impaired fertility. Possible 
risk of irreversible effects. 
S-PHRASES: 22 26 36/37/39 45 
Do not breathe dust. In case of contact with eyes, rinse 
immediately with plenty of water and seek medical advice. Wear 
suitable protective clothing, gloves, and eye/face protection. 
In case of accident or if you feel unwell, seek medical advice 
immediately (show the label where possible). 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
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