Material Safety Data Sheet **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: Pararosaniline Base Catalog Numbers: AC201550000, AC201550100 Synonyms: C.I. 42500 Company Identification (Europe): Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium Company Identification (USA): Acros Organics One Reagent Lane Fairlawn, NJ 07410 For information in North America, call: 800-ACROS-01 For information in Europe, call: 0032(0) 14575211 For emergencies in the US, call CHEMTREC: 800-424-9300 For emergencies in Europe, call: 0032(0) 14575299 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 25620-78-4 |Pararosaniline Base | ca 100 | unlisted | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: XN Risk Phrases: 40 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Possible risks of irreversible effects.The toxicological properties of this material have not been fully investigated.Cancer suspect agent. Potential Health Effects Eye: May cause eye irritation. The toxicological properties of this material have not been fully investigated. Skin: May cause skin irritation. The toxicological properties of this material have not been fully investigated. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia. Chronic: Possible cancer hazard based on tests with laboratory animals. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: For methemoglobinemia, administer oxygen alone or with Methylene blue depending on the methemoglobinemia concentration in the blood. Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia. **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Powder Appearance: purple Odor: None reported. pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate: Not available. Viscosity: Not available. Boiling Point: Decomposes Freezing/Melting Point: 205 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: > 205 deg C Solubility: slightly soluble Specific Gravity/Density: Molecular Formula: C19H19N3O Molecular Weight: 305.38 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, dust generation, excess heat, strong oxidants. Incompatibilities with Other Materials: Oxidizing agents. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 25620-78-4 unlisted. LD50/LC50: Not available. Carcinogenicity: Pararosaniline Base - ACGIH: A3 - Animal Carcinogen (listed as ** undefined **). California: carcinogen; initial date 1/1/90 (listed as ** undefined ** NIOSH: occupational carcinogen (listed as ** undefined **) OSHA: Possible select carcinogen (listed as ** undefined **). IARC: Group 3 carcinogen (listed as ** undefined **). Epidemiology: No information available. Teratogenicity: No information available. Reproductive Effects: No information available. Neurotoxicity: No information available. Mutagenicity: No information available. Other Studies: No data available. **** SECTION 12 - ECOLOGICAL INFORMATION **** **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT No information available Canadian TDG No information available. **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 25620-78-4 is not listed on the TSCA inventory. It is for research and development use only. This material does not contain any Class 2 Ozone depletors. Clean Water Act: CAS# 25620-78-4 is listed as a Hazardous Substance under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Pararosaniline Base can be found on the following state right to know lists: California, (listed as ** no name **), New Jersey, (listed as ** no name **), Florida, (listed as ** no name **), Pennsylvania, (listed as ** no name **), Minnesota, (listed as ** no name **), Massachusetts, (listed as ** no name **). The following statement(s) is(are) made in order to comply with the California Safe Drinking Water Act: WARNING: This product contains Pararosaniline Base, listed as ` ** undefined **', a chemical known to the state of California to cause cancer. California No Significant Risk Level: CAS# 25620-78-4: no significant risk level = 100 ug/day (listed under ** no name **) European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XN Risk Phrases: R 40 Possible risks of irreversible effects. Safety Phrases: S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 25620-78-4: No information available. United Kingdom Occupational Exposure Limits Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 25620-78-4 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 25620-78-4 (listed as ** undefined **): OEL-ARAB Republic of Egyp t:TWA 2 ppm (10 mg/m3);Skin OEL-AUSTRALIA:TWA 2 ppm (10 mg/m3);Skin OEL-AUSTRIA:TWA 2 ppm (8 mg/m3);Skin OEL-BELGIUM:TWA 2 ppm (7.6 mg/m3);Skin OEL-CZECHOSLOVAKIA:TWA 5 mg/m3;STEL 20 mg/m3 JAN9 OEL-DENMARK:TWA 1 ppm (4 mg/m3);Skin OEL-FINLAND:TWA 2 ppm (7.6 mg/m3);STEL 4 ppm (15 mg/m3);Skin;CAR OEL-FRANCE:TWA 2 ppm (10 mg/m3);Skin OEL-GERMANY:TWA 2 ppm (8 mg/m3);Skin;Carcinogen OEL-HUNGARY:TWA 5 mg/m3;STEL 10 mg/m3;Skin OEL-INDIA:TWA 0.2 mg/m3;Skin OEL-JAPAN:TWA 1 ppm (3.8 mg/m3);Skin OEL-THE NETHERLANDS:TWA 5 ppm (19 mg/m3);Skin OEL-THE PHILIPPINES:TWA 5 ppm (19 mg/m3);Skin OEL-POLAND:TWA 5 mg/m3;STEL 20 mg/m3;Skin OEL-RUSSIA:TWA 1 ppm;STEL 0.1 mg/m3;Skin OEL-SWEDEN:TWA 1 ppm (4 mg/m3);STEL 2 ppm (8 mg/m3);Skin OEL-SWITZERLAND:TWA 2 ppm (8 mg/m3);STEL 10 ppm (40 mg/m3);Skin OEL-TURKEY:TWA 5 ppm (19 mg/m3);Skin OEL-UNITED KINGDOM:TWA 2 ppm (10 mg/m3);STEL 5 ppm;Skin OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 1/05/1999 Revision #1 Date: 8/02/2000 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages. --------------------------------------------------------------------------------