SIGMA CHEMICAL COMPANY -- P8139 PHORBOL 12-MYRISTATE 13-ACETATE -- 6810-00F052484 ======================================================= MSDS Safety Information ======================================================= FSC: 6810 MSDS Date: 10/17/1996 MSDS Num: CDBRV LIIN: 00F052484 Tech Review: 01/29/1997 Product ID: P8139 PHORBOL 12-MYRISTATE 13-ACETATE Responsible Party Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST Box: 14508 City: SAINT LOUIS MO 63178-5000 US Info Phone Number: 314-771-5765/800-325-3010 Emergency Phone Number: 314-771-5765/800-325-3010 ======================================================= Preparer Co. when other than Responsible Party Co. ======================================================= Cage: 21076 Assigned Ind: N Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST Box: 14508 City: ST LOUIS MO 63178 ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Address: 3050 SPRUCE ST Box: 14508 City: ST LOUIS MO 63178 US Phone: 314-771-5765 ======================================================= Ingredients ======================================================= Cas: 16561-29-8 RTECS #: QH4377000 Name: PHORBAL 12- ACETATE, 13-MYRISTATE ======================================================= Health Hazards Data ======================================================= Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: MAY BE FATAL IF INHALED, SWALLOWED/ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION OF EYES, SKIN, MUCOUS MEMBRANES & UPPER RESPIRATORY TRACT. Explanation Of Carcinogenicity: NONE Signs And Symptions Of Overexposure: IRRITATION. First Aid: INGESTION: IF CONSCIOUS, WASH MOUTH OUT W/WATER. SKIN/EYES: FLUSH W/COPIOUS AMOUNTS OF WATER FOR 15 MINS. INHALATION: REMOVE TO FRESH AIR. OBTAIN MEDICAL ATTENTION IN ALL CASES. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: EVACUATE AREA. WEAR SCBA, RUBBER BOOTS & HEAVY RUBBER GLOVES. INACTIVATE MATERIAL W/5% SODIUM HYPOCHLORITE. ABSORB ON SAND/VERMICULITE & PLACE IN CLOSED CONTAINERS FOR DISPOSAL. VENTILATE AREA & WASH SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE/MIX MATERIAL W/A COMBUSTIBLE SOLVENT & BURN IN A CHEMICAL INCINERATOR EQUIPPED W/AN AFTERBURNER & SCRUBBER IAW/FEDERAL, STATE & LOCAL REGULATIONS. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: CO2, DRY CHEMICAL POWDER, APPROPRIATE FOAM. Fire Fighting Procedures: WEAR SCBA & PROTECTIVE CLOTHING. Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: WEAR AN APPROPRIATE NIOSH/MSHA APPROVED RESPIRATOR. Ventilation: USE ONLY IN A CHEMICAL FUME HOOD. Protective Gloves: CHEMICAL RESISTANT Eye Protection: SAFETY GOGGLES Other Protective Equipment: OTHER PROTECTIVE CLOTHING, SAFETY SHOWER & EYE BATH. Work Hygienic Practices: REMOVE/LAUNDER CONTAMINATED CLOTHING & SHOES BEFORE REUSE. Supplemental Safety and Health: PHORBOL ESTERS ARE SOME OF THE MOST POTENT TUMOR PROMOTERS KNOWN TO MAN. SOME OF THE PHORBOL ESTERS ENHANCE TUMOR PROMOTION OF KNOWN CARCINOGENS TEN FOLD. USE EXTREME CAUTION WHEN HANDLING THESE COMPO UNDS W/CARCINOGENIC COMPOUNDS. ======================================================= Physical/Chemical Properties ======================================================= Appearance and Odor: SOLID ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Stability Condition To Avoid: FIRE, HEAT, LIGHT. Materials To Avoid: STRONG BASES, STRONG OXIDIZING AGENTS. Hazardous Decomposition Products: CO & CO2. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= ======================================================= Ecological Information ======================================================= ======================================================= MSDS Transport Information ======================================================= ======================================================= Regulatory Information ======================================================= ======================================================= Other Information ======================================================= ======================================================= HAZCOM Label ======================================================= Product ID: P8139 PHORBOL 12-MYRISTATE 13-ACETATE Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY Street: 3050 SPRUCE ST PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 US Health Emergency Phone: 314-771-5765/800-325-3010 Date Of Label Review: 10/12/1999 Hazard And Precautions: MAY BE FATAL IF INHALED, SWALLOWED/ABSORBED THROUGH SKIN. MAY CAUSE IRRITATION OF EYES, SKIN, MUCOUS MEMBRANES & UPPER RESPIRATORY TRACT. ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.