SIGMA CHEMICAL CO -- QUINACRINE DIHYDROCHLORIDE, Q0250 ======================================================= MSDS Safety Information ======================================================= FSC: 6505 MSDS Date: 01/01/1999 MSDS Num: CJWKR LIIN: 00N093120 Product ID: QUINACRINE DIHYDROCHLORIDE, Q0250 MFN: 01 Responsible Party Cage: 21076 Name: SIGMA CHEMICAL CO Box: 14508 City: ST LOUIS MO 63178 Info Phone Number: 314-771-5765 Emergency Phone Number: 314-771-5765 Review Ind: Y Published: Y ======================================================= Contractor Summary ======================================================= Cage: 21076 Name: SIGMA CHEMICAL COMPANY Box: 14508 City: ST LOUIS MO 63178 Phone: 1-314-771-5765 ======================================================= Ingredients ======================================================= Cas: 69-05-6 RTECS #: AR7875000 Name: ACRIDINE, 6-CHLORO-9-((4-(DIETHYLAMINO)-1-METHYLBUTYL)AMINO)-2-METHOXY-, DIHYDROCHLORIDE; (QUINACRINE DIHYDROCHLORIDE). LD50:(ORAL,RAT) 660 MG/KG. Percent by Wt: 100. ======================================================= Health Hazards Data ======================================================= LD50 LC50 Mixture: SEE INGREDIENTS & TOXICOLOGICAL INFO. Route Of Entry Inds - Inhalation: YES Skin: YES Ingestion: YES Carcinogenicity Inds - NTP: NO IARC: NO OSHA: NO Effects of Exposure: ACUTE: HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. TARGET ORGAN DATA: PERIPHERAL NERVE AND SENSATION (FLACCID PARALYSIS WITHOUT ANESTHESIA). SENSE ORGANS AND SPECIAL SENSES (M YDRIASIS). BEHAVIORAL (ALTERED SLEEP TIME; SOMNOLENCE; TOXIC PSYCHOSIS; CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD; EXCITEMENT). VASCULAR (OTHER CHANGES). LUNGS, THORAX OR RESPIRATION (RESPIRATORY DEPRESSION; OTHER CHANGES). GASTROINTESTINA L (CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS; HYPERMOTILITY, DIARRHEA; OTHER CHANGES). LIVER (OTHER CHANGES). KIDNEY, URETER, BLADDER(EFTS OF OVEREXP) Signs And Symptions Of Overexposure: HLTH HAZ: (OTHER CHANGES). IMMUNOLOGICAL INCLUDING ALLERGIC (ANAPHYLAXIS). PATERNAL EFFECTS (SPERMATOGENESIS). MATERNAL EFFECTS (OVARIES, FALLOPIAN TUBES; UTERUS, CERVIX, VAGINA; MENSTRUAL CYCLE CHANGES OR DISORDERS; OTHER EFFECTS ON FEMALE ). EFFECTS ON FERTILITY (FEMALE FERTILITY INDEX; PRE-IMPLANTATION MORTALITY; POST-IMPLANTATION MORTALITY). First Aid: EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. SKIN: IMMEDIATELY WASH WITH SOAP AND COPIOUS AMOUNTS OF WATER. WASH CONTAMINATED CLOTHING BEFORE REUSE. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING GIVE AR TIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL MD. ======================================================= Handling and Disposal ======================================================= Spill Release Procedures: EVACUATE AREA. WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. Waste Disposal Methods: DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. Handling And Storage Precautions: DO NOT BREATHE DUST. DO NOT GET IN EYES, ON SKIN, ON CLOTHING. KEEP TIGHTLY CLOSED. LIGHT SENSITIVE. STORE IN A COOL, DRY PLACE. Other Precautions: LABEL PRECAUTIONARY STATEMENTS: TOXIC (U.S.A.). HARMFUL(EU). HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. ======================================================= Fire and Explosion Hazard Information ======================================================= Extinguishing Media: WATER SPRAY, CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. Fire Fighting Procedures: USE NIOSH APPROVED SCBA AND FULL PROTECTIVE EQUIPMENT (FP N). Unusual Fire/Explosion Hazard: EMITS TOXIC FUMES UNDER FIRE CONDITIONS. ======================================================= Control Measures ======================================================= Respiratory Protection: NIOSH APPROVED RESPIRATOR. Ventilation: USE ONLY IN A CHEMICAL FUME HOOD. Protective Gloves: RUBBER GLOVES. Eye Protection: ANSI APPROVED CHEMICAL WORKERS GOGGLES (FP N). Other Protective Equipment: EYE WASH AND DELUGE SHOWER MEETING ANSI DESIGN CRITERIA (FP N). WEAR SUITABLE PROTECTIVE CLOTHING. Work Hygienic Practices: WASH THOROUGHLY AFTER HANDLING. Supplemental Safety and Health: MFR'S INFORMATION ON INGREDIENTS: MF: C23H30CLN3O. EC NO: 200-700-8. ======================================================= Physical/Chemical Properties ======================================================= Melt/Freeze Pt: =257.C, 494.6F M.P/F.P Text: DECOMPOSES Decomp Temp: =257.C, 494.6F Appearance and Odor: YELLOW POWDER. ======================================================= Reactivity Data ======================================================= Stability Indicator: YES Stability Condition To Avoid: MAY DISCOLOR ON EXPOSURE TO LIGHT. Materials To Avoid: STRONG OXIDIZING AGENTS, STRONG ACIDS. Hazardous Decomposition Products: TOXIC FUMES OF: CARBON MONOXIDE, CARBON DIOXIDE, NITROGEN OXIDES, HYDROGEN CHLORIDE GAS. Hazardous Polymerization Indicator: NO ======================================================= Toxicological Information ======================================================= Toxicological Information: TO THE BEST OF MFR'S KNOWLEDGE, THE CHEMICAL, PHYSICAL & TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED. TOXICITY DATA: LD50:(ORAL,RAT) 660 MG/KG; LD50:(IVN,RAT) 29 MG/KG; LD50:(ORAL,MUS) 557 MG/KG; LD50:(IVN,MUS) 38 MG/KG; LD50:(ORAL,RBT) 433 MG/KG; LD50:(IVN,RBT) 9 MG/KG; LD50:(IVN,GPG) 14 MG/KG - JPETAB 91,157,1947. LD50:(IUT,RAT) 100 MG/KG - IJEBA6 16,1074,1978. LD50:(IPR,MUS) 189 MG/KG - JPETAB 91,133,1947. LD50:(SCU,MUS) 212 MG/KG - ABEMAV 1,317,1941. O NLY SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE INFORMATION. ======================================================= Ecological Information ======================================================= Ecological: DATA NOT YET AVAILABLE. ======================================================= MSDS Transport Information ======================================================= Transport Information: CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. ======================================================= Regulatory Information ======================================================= Federal Regulatory Information: EUROPEAN INFORMATION: HARMFUL; R 20/21/22 - HARMFUL BY INHALATION, IN CONTACT WITH SKIN AND IF SWALLOWED. S 36 - WEAR SUITABLE PROTECTIVE CLOTHING. REVIEWS, STANDARDS AND REGULATIONS: OEL=MAK. NOES 1983: HZD X4102; NIS 1; TNF 66; NOS 3; TNE 987; TFE 508. EPA GENETOX PROGRAM 1988, NEGATIVE: SPERM MORPHOLOGY-MOUSE. EPA GENETOX PROGRAM 1988, INCONCLUSIVE: MAMMALIAN MICRONUCLEUS. EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998. ======================================================= HAZCOM Label ======================================================= Product ID: QUINACRINE DIHYDROCHLORIDE, Q0250 Cage: 21076 Company Name: SIGMA CHEMICAL COMPANY PO Box: 14508 City: ST LOUIS MO Zipcode: 63178 Health Emergency Phone: 314-771-5765 Label Required IND: Y Date Of Label Review: 12/10/1999 Status Code: A Origination Code: F Eye Protection IND: YES Skin Protection IND: YES Signal Word: WARNING Respiratory Protection IND: YES Health Hazard: Moderate Contact Hazard: Moderate Fire Hazard: None Reactivity Hazard: None Hazard And Precautions: ACUTE: HARMFUL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. MAY CAUSE EYE IRRITATION. MAY CAUSE SKIN IRRITATION. CHRONIC: NONE SPECIFIED BY MANUFACTURER (FP N). ======================================================= Disclaimer (provided with this information by the compiling agencies): This information is formulated for use by elements of the Department of Defense. The United States of America in no manner whatsoever expressly or implied warrants, states, or intends said information to have any application, use or viability by or to any person or persons outside the Department of Defense nor any person or persons contracting with any instrumentality of the United States of America and disclaims all liability for such use. Any person utilizing this instruction who is not a military or civilian employee of the United States of America should seek competent professional advice to verify and assume responsibility for the suitability of this information to their particular situation regardless of similarity to a corresponding Department of Defense or other government situation.