SIGMA-ALDRICH 
Material Safety Data Sheet 
Date Printed: 09/OCT/2003 
Date Updated: 23/JUN/2003 
Version 1.1 
According to 91/155/EEC 
1 - Product and Company Information 
Product Name QUININE ANHYDROUS, FOR FLUORESCENCE 
Product Number 22620 
Company Sigma-Aldrich Chemie GmbH 
Riedstrasse 2 
89555 Steinheim 
Germany 
Technical Phone # 49-89-6513(0)-1444 
Fax 49-7329-97-2319 
Emergency Phone # 49 7329 97 2323 
2 - Composition/Information on Ingredients 
Product Name CAS # EC no 
QUININE 130-95-0 205-003-2 
Formula C20H24N2O2 
Molecular Weight 324.44 AMU 
Synonyms Chinin (German),Cinchonan-9-ol, 6'-methoxy-, 
(8-alpha,9R)- (9CI),(8-alpha, 
9R)-6'-Methoxycinchonan-9-ol,6-Methoxycinchonine, 
(-)-Quinine,(8S,9R)-Quinine 
3 - Hazards Identification 
SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT 
Irritating to eyes, respiratory system and skin. May cause 
sensitization by inhalation and skin contact. 
4 - First Aid Measures 
AFTER INHALATION 
If inhaled, remove to fresh air. If breathing becomes difficult, 
call a physician. 
AFTER SKIN CONTACT 
In case of skin contact, flush with copious amounts of water for 
at least 15 minutes. Remove contaminated clothing and shoes. 
Call a physician. 
AFTER EYE CONTACT 
In case of contact with eyes, flush with copious amounts of 
water for at least 15 minutes. Assure adequate flushing by 
separating the eyelids with fingers. Call a physician. 
AFTER INGESTION 
If swallowed, wash out mouth with water provided person is 
conscious. Call a physician. 
5 - Fire Fighting Measures
EXTINGUISHING MEDIA 
Suitable: Water spray. Carbon dioxide, dry chemical powder, or 
appropriate foam. 
SPECIAL RISKS 
Specific Hazard(s): Emits toxic fumes under fire conditions. 
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS 
Wear self-contained breathing apparatus and protective clothing 
to prevent contact with skin and eyes. 
6 - Accidental Release Measures 
PROCEDURE(S) OF PERSONAL PRECAUTION(S) 
Wear respirator, chemical safety goggles, rubber boots, and 
heavy rubber gloves. 
METHODS FOR CLEANING UP 
Sweep up, place in a bag and hold for waste disposal. Avoid 
raising dust. Ventilate area and wash spill site after material 
pickup is complete. 
7 - Handling and Storage 
HANDLING 
Directions for Safe Handling: Avoid breathing dust. Avoid 
contact with eyes, skin, and clothing. Avoid prolonged or 
repeated exposure. 
STORAGE 
Conditions of Storage: Keep tightly closed. 
SPECIAL REQUIREMENTS: Light sensitive. 
8 - Exposure Controls / Personal Protection 
ENGINEERING CONTROLS 
Mechanical exhaust required. 
GENERAL HYGIENE MEASURES 
Wash thoroughly after handling. Wash contaminated clothing before 
reuse. 
9 - Physical and Chemical Properties 
Appearance Physical State: Solid 
Property Value At Temperature or Pressure 
pH N/A 
BP/BP Range N/A 
MP/MP Range 175 °C 
Flash Point N/A 
Flammability N/A 
Autoignition Temp N/A 
Oxidizing Properties N/A 
Explosive Properties N/A 
Explosion Limits N/A 
Vapor Pressure N/A 
Partition Coefficient N/A 
Viscosity N/A 
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Vapor Density N/A 
Saturated Vapor Conc. N/A 
Evaporation Rate N/A 
Bulk Density N/A 
Decomposition Temp. N/A 
Solvent Content N/A 
Water Content N/A 
Surface Tension N/A 
Conductivity N/A 
Miscellaneous Data N/A 
Solubility N/A 
10 - Stability and Reactivity 
STABILITY 
Stable: Stable. 
Conditions of Instability: May decompose on exposure to light. 
Materials to Avoid: Strong oxidizing agents. 
HAZARDOUS DECOMPOSITION PRODUCTS 
Hazardous Decomposition Products: Thermal decomposition may 
produce carbon monoxide, carbon dioxide, and nitrogen oxides. 
HAZARDOUS POLYMERIZATION 
Hazardous Polymerization: Will not occur 
11 - Toxicological Information 
RTECS NUMBER: VA6020000 
ACUTE TOXICITY 
LD50 
Intraperitoneal 
Mouse 
115 MG/KG 
LD50 
Intravenous 
Mouse 
68 MG/KG 
LD50 
Oral 
Guinea pig 
1800 mg/kg 
SENSITIZATION 
Respiratory: May cause allergic respiratory reaction. 
Skin: May cause allergic skin reaction. 
SIGNS AND SYMPTOMS OF EXPOSURE 
Repeated exposure can cause: Blood effects. Stomach pains, 
vomiting, diarrhea. Asthma. 
ROUTE OF EXPOSURE 
Skin Contact: Causes skin irritation. 
Skin Absorption: May be harmful if absorbed through the skin. 
Eye Contact: Causes eye irritation. 
Inhalation: May be harmful if inhaled. Material is irritating to 
mucous membranes and upper respiratory tract. 
Ingestion: May be harmful if swallowed. 
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TARGET ORGAN INFORMATION 
Cardiovascular system. Eyes. Ears. Nerves. G.I. System. 
Pancreas. Skeletal muscle. 
CHRONIC EXPOSURE - MUTAGEN 
Mammal 
100 UMOL/L 
Cell Type: lymphocyte 
DNA 
CHRONIC EXPOSURE - TERATOGEN 
Species: Woman 
Dose: 20 MG/KG 
Route of Application: Oral 
Exposure Time: (4-5W PREG) 
Result: Specific Developmental Abnormalities: Body wall. 
Specific Developmental Abnormalities: Musculoskeletal system. 
Species: Woman 
Dose: 27 UG/KG 
Route of Application: Oral 
Exposure Time: (46-48D PREG) 
Result: Specific Developmental Abnormalities: Body wall. 
Specific Developmental Abnormalities: Cardiovascular 
(circulatory) system. 
Species: Woman 
Dose: 60 MG/KG 
Route of Application: Oral 
Exposure Time: (7W PREG) 
Result: Specific Developmental Abnormalities: Central nervous 
system. Specific Developmental Abnormalities: Musculoskeletal 
system. Specific Developmental Abnormalities: Hepatobiliary 
system. 
Species: Rabbit 
Dose: 280 MG/KG 
Route of Application: Subcutaneous 
Exposure Time: (7-8D PREG) 
Result: Effects on Embryo or Fetus: Fetotoxicity (except death, 
e.g., stunted fetus). Specific Developmental Abnormalities: 
Central nervous system. 
CHRONIC EXPOSURE - REPRODUCTIVE HAZARD 
Species: Rat 
Dose: 10 MG/KG 
Route of Application: Intramuscular 
Exposure Time: (5D PREG) 
Result: Effects on Fertility: Pre-implantation mortality (e.g., 
reduction in number of implants per female; total number of 
implants per corpora lutea). Effects on Fertility: Abortion. 
Effects on Newborn: Stillbirth. 
Species: Rabbit 
Dose: 650 MG/KG 
Route of Application: Subcutaneous 
Exposure Time: (4-8D PREG) 
Result: Effects on Fertility: Post-implantation mortality (e.g., 
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dead and/or resorbed implants per total number of implants). 
Effects on Embryo or Fetus: Fetal death. 
12 - Ecological Information 
No data available. 
13 - Disposal Considerations 
SUBSTANCE DISPOSAL 
Contact a licensed professional waste disposal service to dispose 
of this material. Dissolve or mix the material with a combustible 
solvent and burn in a chemical incinerator equipped with an 
afterburner and scrubber. Observe all federal, state, and local 
environmental regulations. 
14 - Transport Information 
RID/ADR 
Non-hazardous for road transport. 
IMDG 
Non-hazardous for sea transport. 
IATA 
Non-hazardous for air transport. 
15 - Regulatory Information 
CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES 
INDICATION OF DANGER: Xn 
Harmful. 
R-PHRASES: 36/37/38 42/43 
Irritating to eyes, respiratory system and skin. May cause 
sensitization by inhalation and skin contact. 
S-PHRASES: 22 26 36/37 45 
Do not breathe dust. In case of contact with eyes, rinse 
immediately with plenty of water and seek medical advice. Wear 
suitable protective clothing and gloves. In case of accident or 
if you feel unwell, seek medical advice immediately (show the 
label where possible). 
SWITZERLAND 
SWISS POISON CLASS: 3 
16 - Other Information 
WARRANTY 
The above information is believed to be correct but does not 
purport to be all inclusive and shall be used only as a guide. 
Sigma-Aldrich Inc., shall not be held liable for any damage 
resulting from handling or from contact with the above product. 
See reverse side of invoice or packing slip for additional terms 
and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License 
granted to make unlimited paper copies for internal use only. 
DISCLAIMER 
For R&D use only. Not for drug, household or other uses. 
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